Facile, Controlled, Room-Temperature RAFT Polymerization of N-Isopropylacrylamide
Anthony J. Convertine
1
,
Neil Ayres
1
,
Charles W. Scales
1
,
Andrew B Lowe
1
,
Charles L. McCormick
1
1
Department of Polymer Science and Department of Chemistry & Biochemistry, University of Southern Mississippi, Hattiesburg, Mississippi 39406
|
Publication type: Journal Article
Publication date: 2004-06-24
scimago Q1
wos Q1
SJR: 1.142
CiteScore: 9.2
Impact factor: 5.4
ISSN: 15257797, 15264602
PubMed ID:
15244427
Materials Chemistry
Polymers and Plastics
Bioengineering
Biomaterials
Abstract
Poly(N-isopropyl acrylamide) is a thermoresponsive polymer that has been widely investigated for drug delivery. Herein, we report conditions facilitating the controlled, room-temperature RAFT polymerization of N-isopropylacrylamide (NIPAM). The key to success is the appropriate choice of both a suitable RAFT chain transfer agent (CTA) and initiating species. We show that the use of 2-dodecylsulfanylthiocarbonylsulfanyl-2-methyl propionic acid, a trithiocarbonate RAFT CTA, in conjunction with the room-temperature azo initiator 2,2'-azobis(4-methoxy-2,4-dimethylvaleronitrile), in DMF, at 25 degrees C, yields conditions leading to NIPAM homopolymerizations which bear all of the characteristics of a controlled/"living" polymerization. We also demonstrate facile size exclusion chromatographic analysis of PNIPAM samples in DMF at 60 degrees C, directly on aliquots withdrawn during the polymerizations, which avoids the problems previously reported in the literature.
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Convertine A. J. et al. Facile, Controlled, Room-Temperature RAFT Polymerization of N-Isopropylacrylamide // Biomacromolecules. 2004. Vol. 5. No. 4. pp. 1177-1180.
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Convertine A. J., Ayres N., Scales C. W., Lowe A. B., McCormick C. L. Facile, Controlled, Room-Temperature RAFT Polymerization of N-Isopropylacrylamide // Biomacromolecules. 2004. Vol. 5. No. 4. pp. 1177-1180.
Cite this
RIS
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TY - JOUR
DO - 10.1021/bm049825h
UR - https://doi.org/10.1021/bm049825h
TI - Facile, Controlled, Room-Temperature RAFT Polymerization of N-Isopropylacrylamide
T2 - Biomacromolecules
AU - Convertine, Anthony J.
AU - Ayres, Neil
AU - Scales, Charles W.
AU - Lowe, Andrew B
AU - McCormick, Charles L.
PY - 2004
DA - 2004/06/24
PB - American Chemical Society (ACS)
SP - 1177-1180
IS - 4
VL - 5
PMID - 15244427
SN - 1525-7797
SN - 1526-4602
ER -
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BibTex (up to 50 authors)
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@article{2004_Convertine,
author = {Anthony J. Convertine and Neil Ayres and Charles W. Scales and Andrew B Lowe and Charles L. McCormick},
title = {Facile, Controlled, Room-Temperature RAFT Polymerization of N-Isopropylacrylamide},
journal = {Biomacromolecules},
year = {2004},
volume = {5},
publisher = {American Chemical Society (ACS)},
month = {jun},
url = {https://doi.org/10.1021/bm049825h},
number = {4},
pages = {1177--1180},
doi = {10.1021/bm049825h}
}
Cite this
MLA
Copy
Convertine, Anthony J., et al. “Facile, Controlled, Room-Temperature RAFT Polymerization of N-Isopropylacrylamide.” Biomacromolecules, vol. 5, no. 4, Jun. 2004, pp. 1177-1180. https://doi.org/10.1021/bm049825h.