, volume 35 , issue 18 , pages 3620-3625

Identification and Quantification of Estrogen Receptor Agonists in Wastewater Effluents

Shane A. Snyder ¹

Daniel L. Villeneuve ¹

Erin M. Snyder ¹

John P. Giesy ¹

Hide authors affiliations Show authors affiliations: 1 affiliation

Department of Zoology, National Food Safety and Toxicology Center, and Institute for Environmental Toxicology, Michigan State University, East Lansing, Michigan 48824-1311 |

Publication type: Journal Article

Publication date: 2001-08-14

American Chemical Society (ACS)

Environmental Science & Technology

scimago Q1

wos Q1

SJR: 3.690

CiteScore: 18.1

Impact factor: 11.3

ISSN: 0013936X, 15205851

DOI: 10.1021/es001254n

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PubMed ID: 11783637

General Chemistry

Environmental Chemistry

Abstract

Total concentrations of several known xenobiotic estrogen receptor (ER) agonists and natural and synthetic estrogen were measured in water by use of a combination of instrumental and bioanalytical approaches. Samples from 3 municipal wastewater treatment plants (WWTPs) in south central Michigan (upstream and effluent); 4 point source locations on the Trenton Channel of the Detroit River, MI; and 5 locations in Lake Mead, NV were analyzed. Organic compounds were extracted from 5 L water samples using solid-phase extraction disks and separated into three fractions based on polarity. Whole extracts and fractions were tested for ER agonist potency using the MVLN in vitro bioassay. ER agonist potency was characterized by comparing the magnitude of induction elicited by the extract or fraction to the maximum induction caused by 17β-estradiol (E2). The greatest concentrations of ER agonists were associated with the most polar fraction (F3). Instrumental analyses and further fractionation were used to identify specific ER agonists associated with bioassay responses. Bioassay data were compared to extract concentrations in order minimize variability associated with the extraction procedure. Concentrations of endogenous estrogen, E2, and the synthetic estrogen ethynylestradiol (EE2) ranged from nondetectable to 14.6 ng/mL extract (nondetectable to 3.66 ng/L water) and represented from 88 to 99.5% of the total estrogen equivalents in the water samples analyzed. Concentrations of alkylphenols (APs) ranged from nondetectable to 148 μg/mL extract (nondetectable to 37 000 ng/L water). In general, alkylphenols contributed less than 0.5% of the total estrogen equivalents in the water samples. Both bioassay-directed fractionation results and comparison of ER agonist concentrations, adjusted for their known relative potencies, support the conclusion that E2 and EE2 were the dominant environmental estrogens in water samples from mid-Michigan and Lake Mead, NV.

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Snyder S. A. et al. Identification and Quantification of Estrogen Receptor Agonists in Wastewater Effluents // Environmental Science & Technology. 2001. Vol. 35. No. 18. pp. 3620-3625.

GOST all authors (up to 50) Copy

Snyder S. A., Villeneuve D. L., Snyder E. M., Giesy J. P. Identification and Quantification of Estrogen Receptor Agonists in Wastewater Effluents // Environmental Science & Technology. 2001. Vol. 35. No. 18. pp. 3620-3625.

RIS |

Cite this

RIS Copy

TY - JOUR

DO - 10.1021/es001254n

UR - https://doi.org/10.1021/es001254n

TI - Identification and Quantification of Estrogen Receptor Agonists in Wastewater Effluents

T2 - Environmental Science & Technology

AU - Snyder, Shane A.

AU - Villeneuve, Daniel L.

AU - Snyder, Erin M.

AU - Giesy, John P.

PY - 2001

DA - 2001/08/14

PB - American Chemical Society (ACS)

SP - 3620-3625

IS - 18

VL - 35

PMID - 11783637

SN - 0013-936X

SN - 1520-5851

ER -

BibTex |

Cite this

BibTex (up to 50 authors) Copy

@article{2001_Snyder,

author = {Shane A. Snyder and Daniel L. Villeneuve and Erin M. Snyder and John P. Giesy},

title = {Identification and Quantification of Estrogen Receptor Agonists in Wastewater Effluents},

journal = {Environmental Science & Technology},

year = {2001},

volume = {35},

publisher = {American Chemical Society (ACS)},

month = {aug},

url = {https://doi.org/10.1021/es001254n},

number = {18},

pages = {3620--3625},

doi = {10.1021/es001254n}

}

MLA

Cite this

MLA Copy

Snyder, Shane A., et al. “Identification and Quantification of Estrogen Receptor Agonists in Wastewater Effluents.” Environmental Science & Technology, vol. 35, no. 18, Aug. 2001, pp. 3620-3625. https://doi.org/10.1021/es001254n.

Publisher

American Chemical Society (ACS)

Journal

Environmental Science & Technology

scimago Q1

wos Q1

SJR

3.690

CiteScore

18.1

Impact factor

11.3

ISSN

0013936X (Print)

15205851 (Electronic)