Phospholipase C Inhibitors: A New Class of Agents
Тип публикации: Journal Article
Дата публикации: 1994-07-01
SCImago Q1
Tоп 10% SCImago
WOS Q1
БС1
SJR: 1.726
CiteScore: 11.1
Impact factor: 7.3
ISSN: 00222623, 15204804
PubMed ID:
8035430
Drug Discovery
Molecular Medicine
Краткое описание
A series of nitrocoumarin and nitrochromene derivatives have been prepared and shown to inhibit the phosphatidylinositol-specific phospholipase C(PLC)(IC50 < 10 micrograms/mL) isolated from human melanoma. The inhibition of PLC by nitrocoumarin 4a was time-dependent and irreversible. The inhibition of PLC was shown to interfere with inositide metabolism in whole cells (IC50 = 4 micrograms/mL) in a manner consistent with their proposed mode of activity. Finally, the compounds were shown to be growth inhibitory to cultured melanoma cells (ID50 = 2 micrograms/mL), suggesting that PLC may be an attractive new target for chemotherapeutic intervention.
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54
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54
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Цитировать
ГОСТ |
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BibTex |
MLA
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ГОСТ
Скопировать
Perrella F. W. et al. Phospholipase C Inhibitors: A New Class of Agents // Journal of Medicinal Chemistry. 1994. Vol. 37. No. 14. pp. 2232-2237.
ГОСТ со всеми авторами (до 50)
Скопировать
Perrella F. W. Phospholipase C Inhibitors: A New Class of Agents // Journal of Medicinal Chemistry. 1994. Vol. 37. No. 14. pp. 2232-2237.
Цитировать
RIS
Скопировать
TY - JOUR
DO - 10.1021/jm00040a016
UR - https://doi.org/10.1021/jm00040a016
TI - Phospholipase C Inhibitors: A New Class of Agents
T2 - Journal of Medicinal Chemistry
AU - Perrella, Frank W.
PY - 1994
DA - 1994/07/01
PB - American Chemical Society (ACS)
SP - 2232-2237
IS - 14
VL - 37
PMID - 8035430
SN - 0022-2623
SN - 1520-4804
ER -
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BibTex (до 50 авторов)
Скопировать
@article{1994_Perrella,
author = {Frank W. Perrella},
title = {Phospholipase C Inhibitors: A New Class of Agents},
journal = {Journal of Medicinal Chemistry},
year = {1994},
volume = {37},
publisher = {American Chemical Society (ACS)},
month = {jul},
url = {https://doi.org/10.1021/jm00040a016},
number = {14},
pages = {2232--2237},
doi = {10.1021/jm00040a016}
}
Цитировать
MLA
Скопировать
Perrella, Frank W., et al. “Phospholipase C Inhibitors: A New Class of Agents.” Journal of Medicinal Chemistry, vol. 37, no. 14, Jul. 1994, pp. 2232-2237. https://doi.org/10.1021/jm00040a016.
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