6-[(Aminoalkyl)amino]-substituted 7H-benzo[e]perimidin-7-ones as novel antineoplastic agents. Synthesis and biological evaluation
Тип публикации: Journal Article
Дата публикации: 1993-01-01
scimago Q1
wos Q1
БС1
SJR: 1.801
CiteScore: 11.5
Impact factor: 6.8
ISSN: 00222623, 15204804
PubMed ID:
8421288
Drug Discovery
Molecular Medicine
Краткое описание
A class of chromophore-modified anthracenediones with an additional pyrimidine ring incorporated into the chromophore system has been obtained in an attempt to provide compounds with diminished peroxidation activity and thus potentially lowered cardiotoxicity. Their synthesis was carried out by the reaction of 6-amino- or 6-hydroxy-7H-benzo[e]perimidin-7-one with a number of alkylamines. Potent activity was demonstrated in vitro against murine L1210 leukemia cells (equipotent with ametantrone) as well as against P388 leukemia in vivo (% T/C = 130-255). We observed that the benzoperimidines did not stimulate free radical formation, perhaps due to their poor substrate properties for NADH dehydrogenase.
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ГОСТ
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Stefańska B. et al. 6-[(Aminoalkyl)amino]-substituted 7H-benzo[e]perimidin-7-ones as novel antineoplastic agents. Synthesis and biological evaluation // Journal of Medicinal Chemistry. 1993. Vol. 36. No. 1. pp. 38-41.
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Скопировать
Stefańska B. 6-[(Aminoalkyl)amino]-substituted 7H-benzo[e]perimidin-7-ones as novel antineoplastic agents. Synthesis and biological evaluation // Journal of Medicinal Chemistry. 1993. Vol. 36. No. 1. pp. 38-41.
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TY - JOUR
DO - 10.1021/jm00053a005
UR - https://doi.org/10.1021/jm00053a005
TI - 6-[(Aminoalkyl)amino]-substituted 7H-benzo[e]perimidin-7-ones as novel antineoplastic agents. Synthesis and biological evaluation
T2 - Journal of Medicinal Chemistry
AU - Stefańska, Barbara
PY - 1993
DA - 1993/01/01
PB - American Chemical Society (ACS)
SP - 38-41
IS - 1
VL - 36
PMID - 8421288
SN - 0022-2623
SN - 1520-4804
ER -
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BibTex (до 50 авторов)
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@article{1993_Stefańska,
author = {Barbara Stefańska},
title = {6-[(Aminoalkyl)amino]-substituted 7H-benzo[e]perimidin-7-ones as novel antineoplastic agents. Synthesis and biological evaluation},
journal = {Journal of Medicinal Chemistry},
year = {1993},
volume = {36},
publisher = {American Chemical Society (ACS)},
month = {jan},
url = {https://doi.org/10.1021/jm00053a005},
number = {1},
pages = {38--41},
doi = {10.1021/jm00053a005}
}
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MLA
Скопировать
Stefańska, Barbara, et al. “6-[(Aminoalkyl)amino]-substituted 7H-benzo[e]perimidin-7-ones as novel antineoplastic agents. Synthesis and biological evaluation.” Journal of Medicinal Chemistry, vol. 36, no. 1, Jan. 1993, pp. 38-41. https://doi.org/10.1021/jm00053a005.