Dispiro-1,2,4,5-tetraoxanes: a new class of antimalarial peroxides.
Jonathan L. Vennerstrom
1
,
Hong Ning Fu
2
,
William Y Ellis
3
,
Arba L Ager
4
,
James K Wood
5
,
Steven L Andersen
3
,
Lucia Gerena
3
,
Wilbur K. Milhous
3
3
Walter Reed Army Institute of Research
Publication type: Journal Article
Publication date: 1992-08-01
scimago Q1
wos Q1
SJR: 1.801
CiteScore: 11.5
Impact factor: 6.8
ISSN: 00222623, 15204804
PubMed ID:
1501229
Drug Discovery
Molecular Medicine
Abstract
Dispiro-1,2,4,5-tetraoxanes 2-4 were synthesized as potential peroxide antimalarial drugs. They had curative activity against Plasmodium berghei in vivo at single doses of 320 and 640 mg/kg which confirms earlier unpublished data. Moreover, artemisinin (1) and 4 had equivalent ED50's against P. berghei in vivo in the multiple-dose Thompson test; neither showed any evidence of acute toxicity at total doses of more than 12 g/kg. Dispiro-1,2,4,5-tetraoxane 4 had IC50's comparable to those of 1 against Plasmodium falciparum clones in vitro. These results confirm the potential of dispiro-1,2,4,5-tetraoxanes as a new class of inexpensive peroxide antimalarial drugs.
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135
Total citations:
135
Citations from 2024:
6
(4.44%)
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GOST
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Vennerstrom J. L. et al. Dispiro-1,2,4,5-tetraoxanes: a new class of antimalarial peroxides. // Journal of Medicinal Chemistry. 1992. Vol. 35. No. 16. pp. 3023-3027.
GOST all authors (up to 50)
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Vennerstrom J. L., Fu H. N., Ellis W. Y., Ager A. L., Wood J. K., Andersen S. L., Gerena L., Milhous W. K. Dispiro-1,2,4,5-tetraoxanes: a new class of antimalarial peroxides. // Journal of Medicinal Chemistry. 1992. Vol. 35. No. 16. pp. 3023-3027.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1021/jm00094a015
UR - https://doi.org/10.1021/jm00094a015
TI - Dispiro-1,2,4,5-tetraoxanes: a new class of antimalarial peroxides.
T2 - Journal of Medicinal Chemistry
AU - Vennerstrom, Jonathan L.
AU - Fu, Hong Ning
AU - Ellis, William Y
AU - Ager, Arba L
AU - Wood, James K
AU - Andersen, Steven L
AU - Gerena, Lucia
AU - Milhous, Wilbur K.
PY - 1992
DA - 1992/08/01
PB - American Chemical Society (ACS)
SP - 3023-3027
IS - 16
VL - 35
PMID - 1501229
SN - 0022-2623
SN - 1520-4804
ER -
Cite this
BibTex (up to 50 authors)
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@article{1992_Vennerstrom,
author = {Jonathan L. Vennerstrom and Hong Ning Fu and William Y Ellis and Arba L Ager and James K Wood and Steven L Andersen and Lucia Gerena and Wilbur K. Milhous},
title = {Dispiro-1,2,4,5-tetraoxanes: a new class of antimalarial peroxides.},
journal = {Journal of Medicinal Chemistry},
year = {1992},
volume = {35},
publisher = {American Chemical Society (ACS)},
month = {aug},
url = {https://doi.org/10.1021/jm00094a015},
number = {16},
pages = {3023--3027},
doi = {10.1021/jm00094a015}
}
Cite this
MLA
Copy
Vennerstrom, Jonathan L., et al. “Dispiro-1,2,4,5-tetraoxanes: a new class of antimalarial peroxides..” Journal of Medicinal Chemistry, vol. 35, no. 16, Aug. 1992, pp. 3023-3027. https://doi.org/10.1021/jm00094a015.