Comparison of biological effects of N-alkylated congeners of .beta.-phenethylamine derived from 2-aminotetralin, 2-aminoindan, and 6-aminobenzocycloheptene
Publication type: Journal Article
Publication date: 1980-07-01
scimago Q1
wos Q1
SJR: 1.801
CiteScore: 11.5
Impact factor: 6.8
ISSN: 00222623, 15204804
PubMed ID:
7190613
Drug Discovery
Molecular Medicine
Abstract
Three series of bicyclic, semirigid congeners of beta-phenethylamine have been prepared for evaluation of the effect of ring size (and of concomitant conformational variation) on biological activity in a variety of assays for adrenergic and dopaminergic actions. Pharmacologic activity was associated with 2-aminotetralin and 2-aminoindan derivateves, but was not found with 6-aminobenzocycloheptene derivatives. Noteworthy is the ability of several aminotetralins and aminoindans to increase the hot-plate reaction time without eliciting dopaminergic effects. This action was not blocked by pretreatment with naloxone.
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Total citations:
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Citations from 2025:
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(8.33%)
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GOST
Copy
CANNON J. G. et al. Comparison of biological effects of N-alkylated congeners of .beta.-phenethylamine derived from 2-aminotetralin, 2-aminoindan, and 6-aminobenzocycloheptene // Journal of Medicinal Chemistry. 1980. Vol. 23. No. 7. pp. 745-749.
GOST all authors (up to 50)
Copy
CANNON J. G., Pérez J. A., Pease J. P., Long J. P., Flynn J. R., Rusterholz D. B., Dryer S. E. Comparison of biological effects of N-alkylated congeners of .beta.-phenethylamine derived from 2-aminotetralin, 2-aminoindan, and 6-aminobenzocycloheptene // Journal of Medicinal Chemistry. 1980. Vol. 23. No. 7. pp. 745-749.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1021/jm00181a009
UR - https://doi.org/10.1021/jm00181a009
TI - Comparison of biological effects of N-alkylated congeners of .beta.-phenethylamine derived from 2-aminotetralin, 2-aminoindan, and 6-aminobenzocycloheptene
T2 - Journal of Medicinal Chemistry
AU - CANNON, JOSEPH G.
AU - Pérez, Julio A
AU - Pease, Jonathan P
AU - Long, John Paul
AU - Flynn, Jan R
AU - Rusterholz, David B
AU - Dryer, Stuart E.
PY - 1980
DA - 1980/07/01
PB - American Chemical Society (ACS)
SP - 745-749
IS - 7
VL - 23
PMID - 7190613
SN - 0022-2623
SN - 1520-4804
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{1980_CANNON,
author = {JOSEPH G. CANNON and Julio A Pérez and Jonathan P Pease and John Paul Long and Jan R Flynn and David B Rusterholz and Stuart E. Dryer},
title = {Comparison of biological effects of N-alkylated congeners of .beta.-phenethylamine derived from 2-aminotetralin, 2-aminoindan, and 6-aminobenzocycloheptene},
journal = {Journal of Medicinal Chemistry},
year = {1980},
volume = {23},
publisher = {American Chemical Society (ACS)},
month = {jul},
url = {https://doi.org/10.1021/jm00181a009},
number = {7},
pages = {745--749},
doi = {10.1021/jm00181a009}
}
Cite this
MLA
Copy
CANNON, JOSEPH G., et al. “Comparison of biological effects of N-alkylated congeners of .beta.-phenethylamine derived from 2-aminotetralin, 2-aminoindan, and 6-aminobenzocycloheptene.” Journal of Medicinal Chemistry, vol. 23, no. 7, Jul. 1980, pp. 745-749. https://doi.org/10.1021/jm00181a009.