Chiral DNA gyrase inhibitors. 2. Asymmetric synthesis and biological activity of the enantiomers of 9-fluoro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid (ofloxacin)
Тип публикации: Journal Article
Дата публикации: 1987-12-01
SCImago Q1
Tоп 10% SCImago
WOS Q1
БС1
SJR: 1.726
CiteScore: 11.1
Impact factor: 7.3
ISSN: 00222623, 15204804
PubMed ID:
2824776
Drug Discovery
Molecular Medicine
Краткое описание
A short and efficient synthesis, starting with (R)- and (S)-alaninol, of the two optical antipodes of the quinolone antimicrobial agent ofloxacin has been devised. Testing in vitro of the products against a range of bacteria and in an assay system incorporating purified DNA gyrase from different bacterial species demonstrates that the S-(-) enantiomer is substantially the more active.
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ГОСТ
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Mitscher L. A. et al. Chiral DNA gyrase inhibitors. 2. Asymmetric synthesis and biological activity of the enantiomers of 9-fluoro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid (ofloxacin) // Journal of Medicinal Chemistry. 1987. Vol. 30. No. 12. pp. 2283-2286.
ГОСТ со всеми авторами (до 50)
Скопировать
Mitscher L. A. Chiral DNA gyrase inhibitors. 2. Asymmetric synthesis and biological activity of the enantiomers of 9-fluoro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid (ofloxacin) // Journal of Medicinal Chemistry. 1987. Vol. 30. No. 12. pp. 2283-2286.
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RIS
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TY - JOUR
DO - 10.1021/jm00395a017
UR - https://doi.org/10.1021/jm00395a017
TI - Chiral DNA gyrase inhibitors. 2. Asymmetric synthesis and biological activity of the enantiomers of 9-fluoro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid (ofloxacin)
T2 - Journal of Medicinal Chemistry
AU - Mitscher, Lester A.
PY - 1987
DA - 1987/12/01
PB - American Chemical Society (ACS)
SP - 2283-2286
IS - 12
VL - 30
PMID - 2824776
SN - 0022-2623
SN - 1520-4804
ER -
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BibTex (до 50 авторов)
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@article{1987_Mitscher,
author = {Lester A. Mitscher},
title = {Chiral DNA gyrase inhibitors. 2. Asymmetric synthesis and biological activity of the enantiomers of 9-fluoro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid (ofloxacin)},
journal = {Journal of Medicinal Chemistry},
year = {1987},
volume = {30},
publisher = {American Chemical Society (ACS)},
month = {dec},
url = {https://doi.org/10.1021/jm00395a017},
number = {12},
pages = {2283--2286},
doi = {10.1021/jm00395a017}
}
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MLA
Скопировать
Mitscher, Lester A., et al. “Chiral DNA gyrase inhibitors. 2. Asymmetric synthesis and biological activity of the enantiomers of 9-fluoro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid (ofloxacin).” Journal of Medicinal Chemistry, vol. 30, no. 12, Dec. 1987, pp. 2283-2286. https://doi.org/10.1021/jm00395a017.
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