Oxindole Derivatives as Orally Active Potent Growth Hormone Secretagogues
Тип публикации: Journal Article
Дата публикации: 2001-11-16
scimago Q1
wos Q1
БС1
SJR: 1.801
CiteScore: 11.5
Impact factor: 6.8
ISSN: 00222623, 15204804
PubMed ID:
11741481
Drug Discovery
Molecular Medicine
Краткое описание
A series of substituted oxindole derivatives was synthesized and evaluated for growth hormone (GH) releasing activity using cultured rat pituitary cells. (+)-6-Carbamoyl-3-(2-chlorophenyl)-(2-diethylaminoethyl)-4-trifluoromethyloxindole (SM-130686, 37S) was found to have potent activity (EC(50) = 3.0 nM), while the other enantiomer 37R had reduced activity. The absolute configuration of 37S was confirmed by X-ray crystallographic analysis. Compound 37S showed a good pharmacokinetic profile in rats with 28% oral bioavailability at 10 mg/kg and excellent in vivo activity as evidenced by a significant weight gain after 4 days of oral administration at 10 mg/kg twice a day. Compound 37S displaced the binding of (35)S-MK-677 to human GHS-R with an IC(50) value of 1.2 +/- 0.2 nM.
Найдено
Ничего не найдено, попробуйте изменить настройки фильтра.
Для доступа к списку цитирований публикации необходимо авторизоваться.
Для доступа к списку профилей, цитирующих публикацию, необходимо авторизоваться.
Топ-30
Журналы
|
5
10
15
20
|
|
|
Tetrahedron Letters
20 публикаций, 7.41%
|
|
|
Tetrahedron
17 публикаций, 6.3%
|
|
|
Organic and Biomolecular Chemistry
14 публикаций, 5.19%
|
|
|
Journal of Organic Chemistry
13 публикаций, 4.81%
|
|
|
Organic Letters
13 публикаций, 4.81%
|
|
|
European Journal of Organic Chemistry
13 публикаций, 4.81%
|
|
|
Bioorganic and Medicinal Chemistry Letters
9 публикаций, 3.33%
|
|
|
Advanced Synthesis and Catalysis
9 публикаций, 3.33%
|
|
|
Angewandte Chemie
9 публикаций, 3.33%
|
|
|
RSC Advances
9 публикаций, 3.33%
|
|
|
Asian Journal of Organic Chemistry
8 публикаций, 2.96%
|
|
|
Chemistry - A European Journal
8 публикаций, 2.96%
|
|
|
Angewandte Chemie - International Edition
8 публикаций, 2.96%
|
|
|
Chemical Communications
8 публикаций, 2.96%
|
|
|
Green Chemistry
7 публикаций, 2.59%
|
|
|
Organic Chemistry Frontiers
7 публикаций, 2.59%
|
|
|
Chemistry - An Asian Journal
4 публикации, 1.48%
|
|
|
ChemistrySelect
4 публикации, 1.48%
|
|
|
Chemical Record
3 публикации, 1.11%
|
|
|
Bioorganic and Medicinal Chemistry
3 публикации, 1.11%
|
|
|
Tetrahedron Asymmetry
3 публикации, 1.11%
|
|
|
New Journal of Chemistry
3 публикации, 1.11%
|
|
|
Synlett
3 публикации, 1.11%
|
|
|
Synthesis
3 публикации, 1.11%
|
|
|
Australian Journal of Chemistry
2 публикации, 0.74%
|
|
|
Canadian Journal of Chemistry
2 публикации, 0.74%
|
|
|
Acta Crystallographica Section E Structure Reports Online
2 публикации, 0.74%
|
|
|
Journal of the Electrochemical Society
2 публикации, 0.74%
|
|
|
Catalysts
2 публикации, 0.74%
|
|
|
5
10
15
20
|
Издатели
|
10
20
30
40
50
60
70
80
90
|
|
|
Wiley
85 публикаций, 31.48%
|
|
|
Elsevier
68 публикаций, 25.19%
|
|
|
Royal Society of Chemistry (RSC)
48 публикаций, 17.78%
|
|
|
American Chemical Society (ACS)
34 публикации, 12.59%
|
|
|
Georg Thieme Verlag KG
7 публикаций, 2.59%
|
|
|
Taylor & Francis
4 публикации, 1.48%
|
|
|
MDPI
3 публикации, 1.11%
|
|
|
Springer Nature
3 публикации, 1.11%
|
|
|
CSIRO Publishing
2 публикации, 0.74%
|
|
|
Canadian Science Publishing
2 публикации, 0.74%
|
|
|
International Union of Crystallography (IUCr)
2 публикации, 0.74%
|
|
|
The Electrochemical Society
2 публикации, 0.74%
|
|
|
OOO Zhurnal "Mendeleevskie Soobshcheniya"
2 публикации, 0.74%
|
|
|
American Society for Pharmacology and Experimental Therapeutics
1 публикация, 0.37%
|
|
|
Bentham Science Publishers Ltd.
1 публикация, 0.37%
|
|
|
SAGE
1 публикация, 0.37%
|
|
|
The Society of Synthetic Organic Chemistry, Japan
1 публикация, 0.37%
|
|
|
Hrvatsko Farmaceutsko Drustvo/Croatian Pharmaceutical Society
1 публикация, 0.37%
|
|
|
Institute of Chemistry, Academy of Sciences of Moldova
1 публикация, 0.37%
|
|
|
Naksh Solutions
1 публикация, 0.37%
|
|
|
10
20
30
40
50
60
70
80
90
|
- Мы не учитываем публикации, у которых нет DOI.
- Статистика публикаций обновляется еженедельно.
Вы ученый?
Создайте профиль, чтобы получать персональные рекомендации коллег, конференций и новых статей.
Метрики
270
Всего цитирований:
270
Цитирований c 2025:
13
(4.81%)
Цитировать
ГОСТ |
RIS |
BibTex |
MLA
Цитировать
ГОСТ
Скопировать
Tokunaga T. et al. Oxindole Derivatives as Orally Active Potent Growth Hormone Secretagogues // Journal of Medicinal Chemistry. 2001. Vol. 44. No. 26. pp. 4641-4649.
ГОСТ со всеми авторами (до 50)
Скопировать
Tokunaga T., Hume W. E., UMEZOME T., OKAZAKI K., Ueki Y., KUMAGAI K., Hourai S., Nagamine J., Seki H., Taiji M., Noguchi H., Nagata R. Oxindole Derivatives as Orally Active Potent Growth Hormone Secretagogues // Journal of Medicinal Chemistry. 2001. Vol. 44. No. 26. pp. 4641-4649.
Цитировать
RIS
Скопировать
TY - JOUR
DO - 10.1021/jm0103763
UR - https://doi.org/10.1021/jm0103763
TI - Oxindole Derivatives as Orally Active Potent Growth Hormone Secretagogues
T2 - Journal of Medicinal Chemistry
AU - Tokunaga, Teruhisa
AU - Hume, W. Ewan
AU - UMEZOME, Takashi
AU - OKAZAKI, Kazuhiko
AU - Ueki, Yasuyuki
AU - KUMAGAI, Kazuo
AU - Hourai, Shinji
AU - Nagamine, Jun
AU - Seki, Hitoshi
AU - Taiji, Mutsuo
AU - Noguchi, Hiroshi
AU - Nagata, Ryu
PY - 2001
DA - 2001/11/16
PB - American Chemical Society (ACS)
SP - 4641-4649
IS - 26
VL - 44
PMID - 11741481
SN - 0022-2623
SN - 1520-4804
ER -
Цитировать
BibTex (до 50 авторов)
Скопировать
@article{2001_Tokunaga,
author = {Teruhisa Tokunaga and W. Ewan Hume and Takashi UMEZOME and Kazuhiko OKAZAKI and Yasuyuki Ueki and Kazuo KUMAGAI and Shinji Hourai and Jun Nagamine and Hitoshi Seki and Mutsuo Taiji and Hiroshi Noguchi and Ryu Nagata},
title = {Oxindole Derivatives as Orally Active Potent Growth Hormone Secretagogues},
journal = {Journal of Medicinal Chemistry},
year = {2001},
volume = {44},
publisher = {American Chemical Society (ACS)},
month = {nov},
url = {https://doi.org/10.1021/jm0103763},
number = {26},
pages = {4641--4649},
doi = {10.1021/jm0103763}
}
Цитировать
MLA
Скопировать
Tokunaga, Teruhisa, et al. “Oxindole Derivatives as Orally Active Potent Growth Hormone Secretagogues.” Journal of Medicinal Chemistry, vol. 44, no. 26, Nov. 2001, pp. 4641-4649. https://doi.org/10.1021/jm0103763.