Journal of Medicinal Chemistry

, том 45 , издание 6 , страницы 1383-1386

Synthesis and Antimycobacterial Activity of 6-Arylpurines: The Requirements for the N-9 Substituent in Active Antimycobacterial Purines

Тип публикации: Journal Article

Дата публикации: 2002-02-06

American Chemical Society (ACS)

Journal of Medicinal Chemistry

scimago Q1

wos Q1

БС1

SJR: 1.801

CiteScore: 11.5

Impact factor: 6.8

ISSN: 00222623, 15204804

DOI: 10.1021/jm0110284

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PubMed ID: 11882008

Drug Discovery

Molecular Medicine

Краткое описание

6-Arylpurines carrying a variety of substituents in the 9-position were prepared by Stille coupling between appropriately substituted 6-chloropurines and aryl(tributyl)tin, and the compounds were screened for antibacterial activity against Mycobacterium tuberculosis H(37)Rv. The lowest minimum inhibitory concentration value, 0.78 microg/mL, was found for 9-benzyl-2-chloro-6-(2-furyl)purine. This compound exhibited relatively low cytotoxicity, and it was active against several singly drug-resistant strains of M. tuberculosis.

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Gundersen L., Nissen-Meyer J., Spilsberg B. Synthesis and Antimycobacterial Activity of 6-Arylpurines: The Requirements for the N-9 Substituent in Active Antimycobacterial Purines // Journal of Medicinal Chemistry. 2002. Vol. 45. No. 6. pp. 1383-1386.

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TY - JOUR

DO - 10.1021/jm0110284

UR - https://doi.org/10.1021/jm0110284

TI - Synthesis and Antimycobacterial Activity of 6-Arylpurines: The Requirements for the N-9 Substituent in Active Antimycobacterial Purines

T2 - Journal of Medicinal Chemistry

AU - Gundersen, Lise-Lotte

AU - Nissen-Meyer, Jon

AU - Spilsberg, Bjørn

PY - 2002

DA - 2002/02/06

PB - American Chemical Society (ACS)

SP - 1383-1386

IS - 6

VL - 45

PMID - 11882008

SN - 0022-2623

SN - 1520-4804

ER -

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@article{2002_Gundersen,

author = {Lise-Lotte Gundersen and Jon Nissen-Meyer and Bjørn Spilsberg},

title = {Synthesis and Antimycobacterial Activity of 6-Arylpurines: The Requirements for the N-9 Substituent in Active Antimycobacterial Purines},

journal = {Journal of Medicinal Chemistry},

year = {2002},

volume = {45},

publisher = {American Chemical Society (ACS)},

month = {feb},

url = {https://doi.org/10.1021/jm0110284},

number = {6},

pages = {1383--1386},

doi = {10.1021/jm0110284}

}

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Gundersen, Lise-Lotte, et al. “Synthesis and Antimycobacterial Activity of 6-Arylpurines: The Requirements for the N-9 Substituent in Active Antimycobacterial Purines.” Journal of Medicinal Chemistry, vol. 45, no. 6, Feb. 2002, pp. 1383-1386. https://doi.org/10.1021/jm0110284.

Издатель

American Chemical Society (ACS)

Журнал

Journal of Medicinal Chemistry

scimago Q1

wos Q1

БС1

SJR

1.801

CiteScore

11.5

Impact factor

6.8

ISSN

00222623 (Print)

15204804 (Electronic)