Synthesis and Biological Evaluation of 4-Arylcoumarin Analogues of Combretastatins
Christian BAILLY
1
,
Christine Bal
1
,
Pascale Barbier
1
,
Sébastien Combes
1
,
Jean-Pierre Finet
1
,
Marie-Paule Hildebrand
1
,
Vincent Peyrot
1
,
Nicole Wattez
1
Publication type: Journal Article
Publication date: 2003-10-31
scimago Q1
wos Q1
SJR: 1.801
CiteScore: 11.5
Impact factor: 6.8
ISSN: 00222623, 15204804
PubMed ID:
14640552
Drug Discovery
Molecular Medicine
Abstract
A series of A-ring polymethoxylated neoflavonoids was prepared by ligand coupling reactions involving either Suzuki or Stille reactions. Cytotoxicity studies indicated a potent activity against a CEM leukemia cell line for the compounds presenting a substitution pattern related to that of combretastatin A-4. The two compounds having a 3'-OH and a 4'-OCH(3) substituents on the 4-phenyl B-ring have no effect on human topoisomerases I and II but potently inhibit, in vitro, microtubule assembly. At the cell level, the active compounds were characterized as proapoptotic agents, but they can also trigger cell death via a nonapoptotic pathway.
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125
Total citations:
125
Citations from 2024:
5
(4%)
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GOST
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BAILLY C. et al. Synthesis and Biological Evaluation of 4-Arylcoumarin Analogues of Combretastatins // Journal of Medicinal Chemistry. 2003. Vol. 46. No. 25. pp. 5437-5444.
GOST all authors (up to 50)
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BAILLY C., Bal C., Barbier P., Combes S., Finet J., Hildebrand M., Peyrot V., Wattez N. Synthesis and Biological Evaluation of 4-Arylcoumarin Analogues of Combretastatins // Journal of Medicinal Chemistry. 2003. Vol. 46. No. 25. pp. 5437-5444.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1021/jm030903d
UR - https://doi.org/10.1021/jm030903d
TI - Synthesis and Biological Evaluation of 4-Arylcoumarin Analogues of Combretastatins
T2 - Journal of Medicinal Chemistry
AU - BAILLY, Christian
AU - Bal, Christine
AU - Barbier, Pascale
AU - Combes, Sébastien
AU - Finet, Jean-Pierre
AU - Hildebrand, Marie-Paule
AU - Peyrot, Vincent
AU - Wattez, Nicole
PY - 2003
DA - 2003/10/31
PB - American Chemical Society (ACS)
SP - 5437-5444
IS - 25
VL - 46
PMID - 14640552
SN - 0022-2623
SN - 1520-4804
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2003_BAILLY,
author = {Christian BAILLY and Christine Bal and Pascale Barbier and Sébastien Combes and Jean-Pierre Finet and Marie-Paule Hildebrand and Vincent Peyrot and Nicole Wattez},
title = {Synthesis and Biological Evaluation of 4-Arylcoumarin Analogues of Combretastatins},
journal = {Journal of Medicinal Chemistry},
year = {2003},
volume = {46},
publisher = {American Chemical Society (ACS)},
month = {oct},
url = {https://doi.org/10.1021/jm030903d},
number = {25},
pages = {5437--5444},
doi = {10.1021/jm030903d}
}
Cite this
MLA
Copy
BAILLY, Christian, et al. “Synthesis and Biological Evaluation of 4-Arylcoumarin Analogues of Combretastatins.” Journal of Medicinal Chemistry, vol. 46, no. 25, Oct. 2003, pp. 5437-5444. https://doi.org/10.1021/jm030903d.