Novel arylsulfoanilide-oxindole hybrid as an anticancer agent that inhibits translation initiation.
Тип публикации: Journal Article
Дата публикации: 2004-09-04
scimago Q1
wos Q1
БС1
SJR: 1.801
CiteScore: 11.5
Impact factor: 6.8
ISSN: 00222623, 15204804
PubMed ID:
15456240
Drug Discovery
Molecular Medicine
Краткое описание
Structure-activity relationship studies of substituted arylsulfoanilides as antiproliferatives, which are mediated by the partial depletion of intracellular Ca(2+) stores, resulted in the identification of compounds with micromolar activity against lung cancer cells in a growth inhibition assay. Incorporating the substitution pattern of the best arylsulfoanilides onto the 3-phenyloxindole scaffold resulted in a potent arylsulfoanilide-oxindole hybrid, 27. Compound 27 inhibits cancer cell growth by partial depletion of intracellular Ca(2+) stores and phosphorylation of eIF2alpha.
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ГОСТ
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Natarajan A. et al. Novel arylsulfoanilide-oxindole hybrid as an anticancer agent that inhibits translation initiation. // Journal of Medicinal Chemistry. 2004. Vol. 47. No. 21. pp. 4979-4982.
ГОСТ со всеми авторами (до 50)
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Natarajan A., Guo Y., Harbinski F., Fan Y., Chen H., Luus L., Diercks J., Aktas H., Chorev M., Halperin J. Novel arylsulfoanilide-oxindole hybrid as an anticancer agent that inhibits translation initiation. // Journal of Medicinal Chemistry. 2004. Vol. 47. No. 21. pp. 4979-4982.
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RIS
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TY - JOUR
DO - 10.1021/jm0496234
UR - https://doi.org/10.1021/jm0496234
TI - Novel arylsulfoanilide-oxindole hybrid as an anticancer agent that inhibits translation initiation.
T2 - Journal of Medicinal Chemistry
AU - Natarajan, Amarnath
AU - Guo, Yuhong
AU - Harbinski, Frederick
AU - Fan, Yun-Hua
AU - Chen, Han
AU - Luus, Lia
AU - Diercks, Jana
AU - Aktas, Huseyin
AU - Chorev, Michael
AU - Halperin, José
PY - 2004
DA - 2004/09/04
PB - American Chemical Society (ACS)
SP - 4979-4982
IS - 21
VL - 47
PMID - 15456240
SN - 0022-2623
SN - 1520-4804
ER -
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BibTex (до 50 авторов)
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@article{2004_Natarajan,
author = {Amarnath Natarajan and Yuhong Guo and Frederick Harbinski and Yun-Hua Fan and Han Chen and Lia Luus and Jana Diercks and Huseyin Aktas and Michael Chorev and José Halperin},
title = {Novel arylsulfoanilide-oxindole hybrid as an anticancer agent that inhibits translation initiation.},
journal = {Journal of Medicinal Chemistry},
year = {2004},
volume = {47},
publisher = {American Chemical Society (ACS)},
month = {sep},
url = {https://doi.org/10.1021/jm0496234},
number = {21},
pages = {4979--4982},
doi = {10.1021/jm0496234}
}
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MLA
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Natarajan, Amarnath, et al. “Novel arylsulfoanilide-oxindole hybrid as an anticancer agent that inhibits translation initiation..” Journal of Medicinal Chemistry, vol. 47, no. 21, Sep. 2004, pp. 4979-4982. https://doi.org/10.1021/jm0496234.