Antitumor Activity of New Substituted 3-(5-Imidazo[2,1-b]thiazolylmethylene)-2-indolinones and Study of Their Effect on the Cell Cycle
Тип публикации: Journal Article
Дата публикации: 2005-07-28
scimago Q1
wos Q1
БС1
SJR: 1.801
CiteScore: 11.5
Impact factor: 6.8
ISSN: 00222623, 15204804
PubMed ID:
16107161
Drug Discovery
Molecular Medicine
Краткое описание
This paper reports the synthesis of a new series of 3-(5-imidazo[2,1-b]thiazolylmethylene)-2-indolinones which were tested as potential antitumor agents at the National Cancer Institute. Two derivatives are now under review by BEC (Biological Evaluation Committee of NCI). To investigate the mechanism of action, the effect on cell cycle progression was studied by monitoring them in colon adenocarcinoma HT-29: both were able to block HT-29 in mitosis. 3-[(2,6-Dimethylimidazo[2,1-b]thiazol-5-yl)methylene]-5-chloro-2-indolinone was the most active compound.
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Andreani A. et al. Antitumor Activity of New Substituted 3-(5-Imidazo[2,1-b]thiazolylmethylene)-2-indolinones and Study of Their Effect on the Cell Cycle // Journal of Medicinal Chemistry. 2005. Vol. 48. No. 17. pp. 5604-5607.
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Andreani A., Granaiola M., Leoni A., Locatelli A., Morigi R., Rambaldi M., Garaliene V., Welsh W., Arora S., Farruggia G., Masotti L. Antitumor Activity of New Substituted 3-(5-Imidazo[2,1-b]thiazolylmethylene)-2-indolinones and Study of Their Effect on the Cell Cycle // Journal of Medicinal Chemistry. 2005. Vol. 48. No. 17. pp. 5604-5607.
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TY - JOUR
DO - 10.1021/jm050353e
UR - https://doi.org/10.1021/jm050353e
TI - Antitumor Activity of New Substituted 3-(5-Imidazo[2,1-b]thiazolylmethylene)-2-indolinones and Study of Their Effect on the Cell Cycle
T2 - Journal of Medicinal Chemistry
AU - Andreani, Aldo
AU - Granaiola, Massimiliano
AU - Leoni, Alberto
AU - Locatelli, Alessandra
AU - Morigi, Rita
AU - Rambaldi, Mirella
AU - Garaliene, Vida
AU - Welsh, William
AU - Arora, Sonia
AU - Farruggia, Giovanna
AU - Masotti, Lanfranco
PY - 2005
DA - 2005/07/28
PB - American Chemical Society (ACS)
SP - 5604-5607
IS - 17
VL - 48
PMID - 16107161
SN - 0022-2623
SN - 1520-4804
ER -
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@article{2005_Andreani,
author = {Aldo Andreani and Massimiliano Granaiola and Alberto Leoni and Alessandra Locatelli and Rita Morigi and Mirella Rambaldi and Vida Garaliene and William Welsh and Sonia Arora and Giovanna Farruggia and Lanfranco Masotti},
title = {Antitumor Activity of New Substituted 3-(5-Imidazo[2,1-b]thiazolylmethylene)-2-indolinones and Study of Their Effect on the Cell Cycle},
journal = {Journal of Medicinal Chemistry},
year = {2005},
volume = {48},
publisher = {American Chemical Society (ACS)},
month = {jul},
url = {https://doi.org/10.1021/jm050353e},
number = {17},
pages = {5604--5607},
doi = {10.1021/jm050353e}
}
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MLA
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Andreani, Aldo, et al. “Antitumor Activity of New Substituted 3-(5-Imidazo[2,1-b]thiazolylmethylene)-2-indolinones and Study of Their Effect on the Cell Cycle.” Journal of Medicinal Chemistry, vol. 48, no. 17, Jul. 2005, pp. 5604-5607. https://doi.org/10.1021/jm050353e.