N-(3,3a,4,4a,5,5a,6,6a-Octahydro-1,3-dioxo-4,6- ethenocycloprop[f]isoindol-2-(1H)-yl)carboxamides: Identification of Novel Orthopoxvirus Egress Inhibitors
Thomas R. Bailey
1
,
Susan R Rippin
1
,
Elizabeth Opsitnick
1
,
Christopher Burns
1
,
Daniel C Pevear
1
,
Marc S. Collett
1
,
Gerry Rhodes
1
,
Sanjeev Tohan
1
,
John W. Huggins
1
,
Robert O Baker
1
,
EARL R. KERN
1
,
Kathy A Keith
1
,
Dongcheng Dai
1
,
Guang Yang
1
,
Dennis Hruby
1
,
Robert Jordan
1
Publication type: Journal Article
Publication date: 2007-03-03
scimago Q1
wos Q1
SJR: 1.801
CiteScore: 11.5
Impact factor: 6.8
ISSN: 00222623, 15204804
PubMed ID:
17335190
Drug Discovery
Molecular Medicine
Abstract
A series of novel, potent orthopoxvirus egress inhibitors was identified during high-throughput screening of the ViroPharma small molecule collection. Using structure--activity relationship information inferred from early hits, several compounds were synthesized, and compound 14 was identified as a potent, orally bioavailable first-in-class inhibitor of orthopoxvirus egress from infected cells. Compound 14 has shown comparable efficaciousness in three murine orthopoxvirus models and has entered Phase I clinical trials.
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Metrics
55
Total citations:
55
Citations from 2025:
5
(9.09%)
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GOST
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Bailey T. R. et al. N-(3,3a,4,4a,5,5a,6,6a-Octahydro-1,3-dioxo-4,6- ethenocycloprop[f]isoindol-2-(1H)-yl)carboxamides: Identification of Novel Orthopoxvirus Egress Inhibitors // Journal of Medicinal Chemistry. 2007. Vol. 50. No. 7. pp. 1442-1444.
GOST all authors (up to 50)
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Bailey T. R., Rippin S. R., Opsitnick E., Burns C., Pevear D. C., Collett M. S., Rhodes G., Tohan S., Huggins J. W., Baker R. O., KERN E. R., Keith K. A., Dai D., Yang G., Hruby D., Jordan R. N-(3,3a,4,4a,5,5a,6,6a-Octahydro-1,3-dioxo-4,6- ethenocycloprop[f]isoindol-2-(1H)-yl)carboxamides: Identification of Novel Orthopoxvirus Egress Inhibitors // Journal of Medicinal Chemistry. 2007. Vol. 50. No. 7. pp. 1442-1444.
Cite this
RIS
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TY - JOUR
DO - 10.1021/jm061484y
UR - https://doi.org/10.1021/jm061484y
TI - N-(3,3a,4,4a,5,5a,6,6a-Octahydro-1,3-dioxo-4,6- ethenocycloprop[f]isoindol-2-(1H)-yl)carboxamides: Identification of Novel Orthopoxvirus Egress Inhibitors
T2 - Journal of Medicinal Chemistry
AU - Bailey, Thomas R.
AU - Rippin, Susan R
AU - Opsitnick, Elizabeth
AU - Burns, Christopher
AU - Pevear, Daniel C
AU - Collett, Marc S.
AU - Rhodes, Gerry
AU - Tohan, Sanjeev
AU - Huggins, John W.
AU - Baker, Robert O
AU - KERN, EARL R.
AU - Keith, Kathy A
AU - Dai, Dongcheng
AU - Yang, Guang
AU - Hruby, Dennis
AU - Jordan, Robert
PY - 2007
DA - 2007/03/03
PB - American Chemical Society (ACS)
SP - 1442-1444
IS - 7
VL - 50
PMID - 17335190
SN - 0022-2623
SN - 1520-4804
ER -
Cite this
BibTex (up to 50 authors)
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@article{2007_Bailey,
author = {Thomas R. Bailey and Susan R Rippin and Elizabeth Opsitnick and Christopher Burns and Daniel C Pevear and Marc S. Collett and Gerry Rhodes and Sanjeev Tohan and John W. Huggins and Robert O Baker and EARL R. KERN and Kathy A Keith and Dongcheng Dai and Guang Yang and Dennis Hruby and Robert Jordan},
title = {N-(3,3a,4,4a,5,5a,6,6a-Octahydro-1,3-dioxo-4,6- ethenocycloprop[f]isoindol-2-(1H)-yl)carboxamides: Identification of Novel Orthopoxvirus Egress Inhibitors},
journal = {Journal of Medicinal Chemistry},
year = {2007},
volume = {50},
publisher = {American Chemical Society (ACS)},
month = {mar},
url = {https://doi.org/10.1021/jm061484y},
number = {7},
pages = {1442--1444},
doi = {10.1021/jm061484y}
}
Cite this
MLA
Copy
Bailey, Thomas R., et al. “N-(3,3a,4,4a,5,5a,6,6a-Octahydro-1,3-dioxo-4,6- ethenocycloprop[f]isoindol-2-(1H)-yl)carboxamides: Identification of Novel Orthopoxvirus Egress Inhibitors.” Journal of Medicinal Chemistry, vol. 50, no. 7, Mar. 2007, pp. 1442-1444. https://doi.org/10.1021/jm061484y.