Positive Allosteric Modulators of the α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptor
1
Merck Research Laboratories, MSD Ltd., Newhouse, Motherwell, Lanarkshire ML1 5SH, U.K.
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Тип публикации: Journal Article
Дата публикации: 2010-09-14
scimago Q1
wos Q1
БС1
SJR: 1.801
CiteScore: 11.5
Impact factor: 6.8
ISSN: 00222623, 15204804
PubMed ID:
20839777
Drug Discovery
Molecular Medicine
Краткое описание
L-glutamate is the major excitatory neurotransmitter in the mammalian central nervous system (CNS) and plays a fundamental role in the control of motor function, cognition and mood. The physiological effects of glutamate are mediated through two functionally distinct receptor families. While activation of metabotropic (G-protein coupled) glutamate receptors results in modulation of neuronal excitability and transmission, the ionotropic glutamate receptors (ligand-gated ion channels) are responsible for mediating the fast synaptic response to extracellular glutamate.
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MLA
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ГОСТ
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GROVE S. J. A. et al. Positive Allosteric Modulators of the α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptor // Journal of Medicinal Chemistry. 2010. Vol. 53. No. 20. pp. 7271-7279.
ГОСТ со всеми авторами (до 50)
Скопировать
GROVE S. J. A., Jamieson C., Maclean J. K., Morrow J. A., Rankovic Z. Positive Allosteric Modulators of the α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptor // Journal of Medicinal Chemistry. 2010. Vol. 53. No. 20. pp. 7271-7279.
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TY - JOUR
DO - 10.1021/jm1000419
UR - https://doi.org/10.1021/jm1000419
TI - Positive Allosteric Modulators of the α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptor
T2 - Journal of Medicinal Chemistry
AU - GROVE, Simon J. A.
AU - Jamieson, Craig
AU - Maclean, John K.F.
AU - Morrow, John A
AU - Rankovic, Zoran
PY - 2010
DA - 2010/09/14
PB - American Chemical Society (ACS)
SP - 7271-7279
IS - 20
VL - 53
PMID - 20839777
SN - 0022-2623
SN - 1520-4804
ER -
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BibTex (до 50 авторов)
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@article{2010_GROVE,
author = {Simon J. A. GROVE and Craig Jamieson and John K.F. Maclean and John A Morrow and Zoran Rankovic},
title = {Positive Allosteric Modulators of the α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptor},
journal = {Journal of Medicinal Chemistry},
year = {2010},
volume = {53},
publisher = {American Chemical Society (ACS)},
month = {sep},
url = {https://doi.org/10.1021/jm1000419},
number = {20},
pages = {7271--7279},
doi = {10.1021/jm1000419}
}
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MLA
Скопировать
GROVE, Simon J. A., et al. “Positive Allosteric Modulators of the α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptor.” Journal of Medicinal Chemistry, vol. 53, no. 20, Sep. 2010, pp. 7271-7279. https://doi.org/10.1021/jm1000419.