Highly Potent Activity of (1R,2R,6S)-3-Methyl-6-(prop-1-en-2-yl)cyclohex-3-ene-1,2-diol in Animal Models of Parkinson’s Disease
Publication type: Journal Article
Publication date: 2011-05-13
scimago Q1
wos Q1
SJR: 1.801
CiteScore: 11.5
Impact factor: 6.8
ISSN: 00222623, 15204804
PubMed ID:
21534547
Drug Discovery
Molecular Medicine
Abstract
(1R,2R,6S)-3-Methyl-6-(prop-1-en-2-yl)cyclohex-3-ene-1,2-diol 1 possesses potent antiparkinsonian activity in both MPTP and haloperidol animal models. The use of compound 1 resulted in nearly full recovery of the locomotor and exploratory activities and was as effective as the comparator agent (levodopa). All eight stereoisomers of compound 1 have been synthesized and the influence of the absolute configuration on the antiparkinsonian activity of compound 1 was shown.
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67
Total citations:
67
Citations from 2024:
10
(14.93%)
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MLA
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GOST
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Ardashov O. V. et al. Highly Potent Activity of (1R,2R,6S)-3-Methyl-6-(prop-1-en-2-yl)cyclohex-3-ene-1,2-diol in Animal Models of Parkinson’s Disease // Journal of Medicinal Chemistry. 2011. Vol. 54. No. 11. pp. 3866-3874.
GOST all authors (up to 50)
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Ardashov O. V., Pavlova A. V., Ilina I. V., Morozova E. A., Korchagina D. V., Karpova E. V., Volcho K. P., Tolstikova T. G., Salakhutdinov N. F. Highly Potent Activity of (1R,2R,6S)-3-Methyl-6-(prop-1-en-2-yl)cyclohex-3-ene-1,2-diol in Animal Models of Parkinson’s Disease // Journal of Medicinal Chemistry. 2011. Vol. 54. No. 11. pp. 3866-3874.
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RIS
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TY - JOUR
DO - 10.1021/jm2001579
UR - https://doi.org/10.1021/jm2001579
TI - Highly Potent Activity of (1R,2R,6S)-3-Methyl-6-(prop-1-en-2-yl)cyclohex-3-ene-1,2-diol in Animal Models of Parkinson’s Disease
T2 - Journal of Medicinal Chemistry
AU - Ardashov, Oleg V
AU - Pavlova, Alla V
AU - Ilina, Irina V
AU - Morozova, Ekaterina A
AU - Korchagina, Dina V.
AU - Karpova, Elena V.
AU - Volcho, Konstantin P.
AU - Tolstikova, Tatyana G.
AU - Salakhutdinov, Nariman F.
PY - 2011
DA - 2011/05/13
PB - American Chemical Society (ACS)
SP - 3866-3874
IS - 11
VL - 54
PMID - 21534547
SN - 0022-2623
SN - 1520-4804
ER -
Cite this
BibTex (up to 50 authors)
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@article{2011_Ardashov,
author = {Oleg V Ardashov and Alla V Pavlova and Irina V Ilina and Ekaterina A Morozova and Dina V. Korchagina and Elena V. Karpova and Konstantin P. Volcho and Tatyana G. Tolstikova and Nariman F. Salakhutdinov},
title = {Highly Potent Activity of (1R,2R,6S)-3-Methyl-6-(prop-1-en-2-yl)cyclohex-3-ene-1,2-diol in Animal Models of Parkinson’s Disease},
journal = {Journal of Medicinal Chemistry},
year = {2011},
volume = {54},
publisher = {American Chemical Society (ACS)},
month = {may},
url = {https://doi.org/10.1021/jm2001579},
number = {11},
pages = {3866--3874},
doi = {10.1021/jm2001579}
}
Cite this
MLA
Copy
Ardashov, Oleg V., et al. “Highly Potent Activity of (1R,2R,6S)-3-Methyl-6-(prop-1-en-2-yl)cyclohex-3-ene-1,2-diol in Animal Models of Parkinson’s Disease.” Journal of Medicinal Chemistry, vol. 54, no. 11, May. 2011, pp. 3866-3874. https://doi.org/10.1021/jm2001579.