Journal of Medicinal Chemistry, volume 55, issue 5, pages 1957-1968
Copper(II) Complexes of Salicylic Acid Combining Superoxide Dismutase Mimetic Properties with DNA Binding and Cleaving Capabilities Display Promising Chemotherapeutic Potential with Fast Acting in Vitro Cytotoxicity against Cisplatin Sensitive and Resistant Cancer Cell Lines
Mark O’Connor
1
,
Andrew Kellett
1
,
Malachy McCann
2
,
Georgina M. Rosair
3
,
MARY MCNAMARA
1
,
Orla Howe
1
,
B. Creaven
4
,
SIOBHAN McCLEAN
4
,
Agnieszka Foltyn Arfa Kia
4
,
Denis O’Shea
1
,
Michael Devereux
1
1
The Inorganic Pharmaceutical
and Biomimetic Research Centre, Focas Research Institute, Dublin Institute of Technology, Camden Row, Dublin
8, Ireland
|
2
Chemistry Department, National University of Ireland, Maynooth, County Kildare,
Ireland
|
4
Centre of
Applied Science for
Health, Institute of Technology Tallaght Dublin, Tallaght, Dublin 24, Ireland
|
Publication type: Journal Article
Publication date: 2012-02-28
Journal:
Journal of Medicinal Chemistry
Quartile SCImago
Q1
Quartile WOS
Q1
SJR: 1.986
CiteScore: 12.8
Impact factor: 6.8
ISSN: 00222623, 15204804
Drug Discovery
Molecular Medicine
Abstract
The complexes [Cu(salH)(2)(H(2)O)] (1), [Cu(dipsH)(2)(H(2)O)] (2), {Cu(3-MeOsal)(H(2)O)(0.75)}(n) (3), [Cu(dipsH)(2)(BZDH)(2)] (4), [Cu(dipsH)(2)(2-MeOHBZDH)(2)]·EtOH (5), [Cu(sal)(phen)] (6), [Cu(dips)(phen)]·H(2)O (7), and [Cu(3-MeOsal)(phen)]·H(2)O (8) (salH(2) = salicylic acid; dipsH(2) = 3,5-diisopropylsalicylic acid; 3-MeOsalH(2) = 3-methoxysalicylic acid; BZDH = benzimidazole; 2-MeOHBZDH = 2 methanolbenzimidazole and phen =1,10-phenanthroline) were prepared and characterized. Structures of 4, 5, and 8 were determined by X-ray crystallography. Compounds 1-8 are potent superoxide dismutase mimetics, and they are inactive as inhibitors of COX-2 activity. Compounds 1, 4, and 5 exhibit moderate inhibition of COX-1. Complexes 6-8 display rapid micromolar cytotoxicity against cisplatin sensitive (breast (MCF-7), prostate (DU145), and colon (HT29)) and cisplatin resistant (ovarian (SK-OV-3)) cell lines compared to 1-5, and they exhibit potent in vitro DNA binding and cleavage capabilities.
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GOST
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O’Connor M. et al. Copper(II) Complexes of Salicylic Acid Combining Superoxide Dismutase Mimetic Properties with DNA Binding and Cleaving Capabilities Display Promising Chemotherapeutic Potential with Fast Acting in Vitro Cytotoxicity against Cisplatin Sensitive and Resistant Cancer Cell Lines // Journal of Medicinal Chemistry. 2012. Vol. 55. No. 5. pp. 1957-1968.
GOST all authors (up to 50)
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O’Connor M., Kellett A., McCann M., Rosair G. M., MCNAMARA M., Howe O., Creaven B., McCLEAN S., Foltyn Arfa Kia A., O’Shea D., Devereux M. Copper(II) Complexes of Salicylic Acid Combining Superoxide Dismutase Mimetic Properties with DNA Binding and Cleaving Capabilities Display Promising Chemotherapeutic Potential with Fast Acting in Vitro Cytotoxicity against Cisplatin Sensitive and Resistant Cancer Cell Lines // Journal of Medicinal Chemistry. 2012. Vol. 55. No. 5. pp. 1957-1968.
Cite this
RIS
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TY - JOUR
DO - 10.1021/jm201041d
UR - https://doi.org/10.1021/jm201041d
TI - Copper(II) Complexes of Salicylic Acid Combining Superoxide Dismutase Mimetic Properties with DNA Binding and Cleaving Capabilities Display Promising Chemotherapeutic Potential with Fast Acting in Vitro Cytotoxicity against Cisplatin Sensitive and Resistant Cancer Cell Lines
T2 - Journal of Medicinal Chemistry
AU - McCann, Malachy
AU - MCNAMARA, MARY
AU - Foltyn Arfa Kia, Agnieszka
AU - O’Shea, Denis
AU - O’Connor, Mark
AU - Kellett, Andrew
AU - Rosair, Georgina M.
AU - Howe, Orla
AU - Creaven, B.
AU - McCLEAN, SIOBHAN
AU - Devereux, Michael
PY - 2012
DA - 2012/02/28
PB - American Chemical Society (ACS)
SP - 1957-1968
IS - 5
VL - 55
SN - 0022-2623
SN - 1520-4804
ER -
Cite this
BibTex
Copy
@article{2012_O’Connor,
author = {Malachy McCann and MARY MCNAMARA and Agnieszka Foltyn Arfa Kia and Denis O’Shea and Mark O’Connor and Andrew Kellett and Georgina M. Rosair and Orla Howe and B. Creaven and SIOBHAN McCLEAN and Michael Devereux},
title = {Copper(II) Complexes of Salicylic Acid Combining Superoxide Dismutase Mimetic Properties with DNA Binding and Cleaving Capabilities Display Promising Chemotherapeutic Potential with Fast Acting in Vitro Cytotoxicity against Cisplatin Sensitive and Resistant Cancer Cell Lines},
journal = {Journal of Medicinal Chemistry},
year = {2012},
volume = {55},
publisher = {American Chemical Society (ACS)},
month = {feb},
url = {https://doi.org/10.1021/jm201041d},
number = {5},
pages = {1957--1968},
doi = {10.1021/jm201041d}
}
Cite this
MLA
Copy
O’Connor, Mark, et al. “Copper(II) Complexes of Salicylic Acid Combining Superoxide Dismutase Mimetic Properties with DNA Binding and Cleaving Capabilities Display Promising Chemotherapeutic Potential with Fast Acting in Vitro Cytotoxicity against Cisplatin Sensitive and Resistant Cancer Cell Lines.” Journal of Medicinal Chemistry, vol. 55, no. 5, Feb. 2012, pp. 1957-1968. https://doi.org/10.1021/jm201041d.