Plant Growth Regulator Daminozide Is a Selective Inhibitor of Human KDM2/7 Histone Demethylases
Тип публикации: Journal Article
Дата публикации: 2012-07-11
SCImago Q1
Tоп 10% SCImago
WOS Q1
БС1
SJR: 1.726
CiteScore: 11.5
Impact factor: 6.8
ISSN: 00222623, 15204804
PubMed ID:
22724510
Drug Discovery
Molecular Medicine
Краткое описание
The JmjC oxygenases catalyze the N-demethylation of N(ε)-methyl lysine residues in histones and are current therapeutic targets. A set of human 2-oxoglutarate analogues were screened using a unified assay platform for JmjC demethylases and related oxygenases. Results led to the finding that daminozide (N-(dimethylamino)succinamic acid, 160 Da), a plant growth regulator, selectively inhibits the KDM2/7 JmjC subfamily. Kinetic and crystallographic studies reveal that daminozide chelates the active site metal via its hydrazide carbonyl and dimethylamino groups.
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ГОСТ
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Rose N. R. et al. Plant Growth Regulator Daminozide Is a Selective Inhibitor of Human KDM2/7 Histone Demethylases // Journal of Medicinal Chemistry. 2012. Vol. 55. No. 14. pp. 6639-6643.
ГОСТ со всеми авторами (до 50)
Скопировать
Rose N. R., Woon E. C. Y., Tumber A., Walport L. J., Chowdhury R., Li X. S., King O. N. F., Lejeune C., Ng S. S., Krojer T., Chan M. C., Rydzik A. M., Hopkinson R. J., Che K. H., Daniel M., Strain-Damerell C., Gileadi C., Kochan G., Leung I. H., Dunford J. E., Yeoh K., RATCLIFFE P. J., Burgess-Brown N., von Delft F., Müller S., Marsden B. G., Brennan P. M., McDonough M., Oppermann U. C., Klose R. J., Schofield C. J., Kawamura A. Plant Growth Regulator Daminozide Is a Selective Inhibitor of Human KDM2/7 Histone Demethylases // Journal of Medicinal Chemistry. 2012. Vol. 55. No. 14. pp. 6639-6643.
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TY - JOUR
DO - 10.1021/jm300677j
UR - https://doi.org/10.1021/jm300677j
TI - Plant Growth Regulator Daminozide Is a Selective Inhibitor of Human KDM2/7 Histone Demethylases
T2 - Journal of Medicinal Chemistry
AU - Rose, Nathan R
AU - Woon, Esther C Y
AU - Tumber, Anthony
AU - Walport, Louise J
AU - Chowdhury, Rasheduzzaman
AU - Li, Xuan Shirley
AU - King, Oliver N F
AU - Lejeune, Clarisse
AU - Ng, Stanley S
AU - Krojer, Tobias
AU - Chan, Mun Chiang
AU - Rydzik, Anna M
AU - Hopkinson, Richard J.
AU - Che, Ka Hing
AU - Daniel, Michelle
AU - Strain-Damerell, Claire
AU - Gileadi, Carina
AU - Kochan, Grazyna
AU - Leung, Ivanhoe K. H.
AU - Dunford, James E
AU - Yeoh, Kar Kheng
AU - RATCLIFFE, P. J.
AU - Burgess-Brown, Nicola
AU - von Delft, Frank
AU - Müller, Susanne
AU - Marsden, Brian G.
AU - Brennan, Paul M.
AU - McDonough, Michael
AU - Oppermann, Udo C.I.
AU - Klose, Robert J.
AU - Schofield, Christopher J.
AU - Kawamura, Akane
PY - 2012
DA - 2012/07/11
PB - American Chemical Society (ACS)
SP - 6639-6643
IS - 14
VL - 55
PMID - 22724510
SN - 0022-2623
SN - 1520-4804
ER -
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@article{2012_Rose,
author = {Nathan R Rose and Esther C Y Woon and Anthony Tumber and Louise J Walport and Rasheduzzaman Chowdhury and Xuan Shirley Li and Oliver N F King and Clarisse Lejeune and Stanley S Ng and Tobias Krojer and Mun Chiang Chan and Anna M Rydzik and Richard J. Hopkinson and Ka Hing Che and Michelle Daniel and Claire Strain-Damerell and Carina Gileadi and Grazyna Kochan and Ivanhoe K. H. Leung and James E Dunford and Kar Kheng Yeoh and P. J. RATCLIFFE and Nicola Burgess-Brown and Frank von Delft and Susanne Müller and Brian G. Marsden and Paul M. Brennan and Michael McDonough and Udo C.I. Oppermann and Robert J. Klose and Christopher J. Schofield and Akane Kawamura},
title = {Plant Growth Regulator Daminozide Is a Selective Inhibitor of Human KDM2/7 Histone Demethylases},
journal = {Journal of Medicinal Chemistry},
year = {2012},
volume = {55},
publisher = {American Chemical Society (ACS)},
month = {jul},
url = {https://doi.org/10.1021/jm300677j},
number = {14},
pages = {6639--6643},
doi = {10.1021/jm300677j}
}
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MLA
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Rose, Nathan R., et al. “Plant Growth Regulator Daminozide Is a Selective Inhibitor of Human KDM2/7 Histone Demethylases.” Journal of Medicinal Chemistry, vol. 55, no. 14, Jul. 2012, pp. 6639-6643. https://doi.org/10.1021/jm300677j.
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