Journal of Medicinal Chemistry

, том 56 , издание 18 , страницы 7222-7231

Identification of the KDM2/7 Histone Lysine Demethylase Subfamily Inhibitor and its Antiproliferative Activity

Тип публикации: Journal Article

Дата публикации: 2013-09-05

American Chemical Society (ACS)

Journal of Medicinal Chemistry

SCImago Q1

Tоп 10% SCImago

WOS Q1

БС1

SJR: 1.726

CiteScore: 11.5

Impact factor: 6.8

ISSN: 00222623, 15204804

DOI: 10.1021/jm400624b

Скопировать DOI

PubMed ID: 23964788

Drug Discovery

Molecular Medicine

Краткое описание

Histone N(ε)-methyl lysine demethylases KDM2/7 have been identified as potential targets for cancer therapies. On the basis of the crystal structure of KDM7B, we designed and prepared a series of hydroxamate analogues bearing an alkyl chain. Enzyme assays revealed that compound 9 potently inhibits KDM2A, KDM7A, and KDM7B, with IC50s of 6.8, 0.2, and 1.2 μM, respectively. While inhibitors of KDM4s did not show any effect on cancer cells tested, the KDM2/7-subfamily inhibitor 9 exerted antiproliferative activity, indicating the potential for KDM2/7 inhibitors as anticancer agents.

Для доступа к списку цитирований публикации необходимо авторизоваться.

Войти с ORCID

Для доступа к списку профилей, цитирующих публикацию, необходимо авторизоваться.

Войти с ORCID

Топ-30

Журналы

	1 2 3
Future Medicinal Chemistry	Future Medicinal Chemistry, 3, 3.45% Future Medicinal Chemistry 3 публикации, 3.45%
European Journal of Medicinal Chemistry	European Journal of Medicinal Chemistry, 3, 3.45% European Journal of Medicinal Chemistry 3 публикации, 3.45%
Journal of Medicinal Chemistry	Journal of Medicinal Chemistry, 3, 3.45% Journal of Medicinal Chemistry 3 публикации, 3.45%
Cellular and Molecular Life Sciences	Cellular and Molecular Life Sciences, 2, 2.3% Cellular and Molecular Life Sciences 2 публикации, 2.3%
Scientific Reports	Scientific Reports, 2, 2.3% Scientific Reports 2 публикации, 2.3%
Pharmacology and Therapeutics	Pharmacology and Therapeutics, 2, 2.3% Pharmacology and Therapeutics 2 публикации, 2.3%
Bioorganic and Medicinal Chemistry	Bioorganic and Medicinal Chemistry, 2, 2.3% Bioorganic and Medicinal Chemistry 2 публикации, 2.3%
Bioorganic and Medicinal Chemistry Letters	Bioorganic and Medicinal Chemistry Letters, 2, 2.3% Bioorganic and Medicinal Chemistry Letters 2 публикации, 2.3%
ChemMedChem	ChemMedChem, 2, 2.3% ChemMedChem 2 публикации, 2.3%
Chemical Reviews	Chemical Reviews, 2, 2.3% Chemical Reviews 2 публикации, 2.3%
Biochemical Pharmacology	Biochemical Pharmacology, 2, 2.3% Biochemical Pharmacology 2 публикации, 2.3%
Advances in Experimental Medicine and Biology	Advances in Experimental Medicine and Biology, 2, 2.3% Advances in Experimental Medicine and Biology 2 публикации, 2.3%
Current Medicinal Chemistry	Current Medicinal Chemistry, 1, 1.15% Current Medicinal Chemistry 1 публикация, 1.15%
Oncotarget	Oncotarget, 1, 1.15% Oncotarget 1 публикация, 1.15%
Chemical and Pharmaceutical Bulletin	Chemical and Pharmaceutical Bulletin, 1, 1.15% Chemical and Pharmaceutical Bulletin 1 публикация, 1.15%
Yakugaku Zasshi	Yakugaku Zasshi, 1, 1.15% Yakugaku Zasshi 1 публикация, 1.15%
International Journal of Oncology	International Journal of Oncology, 1, 1.15% International Journal of Oncology 1 публикация, 1.15%
Nature Chemical Biology	Nature Chemical Biology, 1, 1.15% Nature Chemical Biology 1 публикация, 1.15%
Frontiers in Immunology	Frontiers in Immunology, 1, 1.15% Frontiers in Immunology 1 публикация, 1.15%
Yuki Gosei Kagaku Kyokaishi/Journal of Synthetic Organic Chemistry	Yuki Gosei Kagaku Kyokaishi/Journal of Synthetic Organic Chemistry, 1, 1.15% Yuki Gosei Kagaku Kyokaishi/Journal of Synthetic Organic Chemistry 1 публикация, 1.15%
Tumor Biology	Tumor Biology, 1, 1.15% Tumor Biology 1 публикация, 1.15%
Nature Communications	Nature Communications, 1, 1.15% Nature Communications 1 публикация, 1.15%
SLAS Discovery	SLAS Discovery, 1, 1.15% SLAS Discovery 1 публикация, 1.15%
Drug Discovery Today	Drug Discovery Today, 1, 1.15% Drug Discovery Today 1 публикация, 1.15%
Current Opinion in Pharmacology	Current Opinion in Pharmacology, 1, 1.15% Current Opinion in Pharmacology 1 публикация, 1.15%
Current Opinion in Chemical Biology	Current Opinion in Chemical Biology, 1, 1.15% Current Opinion in Chemical Biology 1 публикация, 1.15%
Biochimica et Biophysica Acta - Gene Regulatory Mechanisms	Biochimica et Biophysica Acta - Gene Regulatory Mechanisms, 1, 1.15% Biochimica et Biophysica Acta - Gene Regulatory Mechanisms 1 публикация, 1.15%
ChemBioChem	ChemBioChem, 1, 1.15% ChemBioChem 1 публикация, 1.15%
Angewandte Chemie - International Edition	Angewandte Chemie - International Edition, 1, 1.15% Angewandte Chemie - International Edition 1 публикация, 1.15%
	1 2 3

Издатели

	5 10 15 20 25 30
Elsevier	Elsevier, 27, 31.03% Elsevier 27 публикаций, 31.03%
Wiley	Wiley, 14, 16.09% Wiley 14 публикаций, 16.09%
Springer Nature	Springer Nature, 12, 13.79% Springer Nature 12 публикаций, 13.79%
American Chemical Society (ACS)	American Chemical Society (ACS), 9, 10.34% American Chemical Society (ACS) 9 публикаций, 10.34%
Taylor & Francis	Taylor & Francis, 5, 5.75% Taylor & Francis 5 публикаций, 5.75%
Royal Society of Chemistry (RSC)	Royal Society of Chemistry (RSC), 4, 4.6% Royal Society of Chemistry (RSC) 4 публикации, 4.6%
Pharmaceutical Society of Japan	Pharmaceutical Society of Japan, 2, 2.3% Pharmaceutical Society of Japan 2 публикации, 2.3%
Spandidos Publications	Spandidos Publications, 2, 2.3% Spandidos Publications 2 публикации, 2.3%
SAGE	SAGE, 2, 2.3% SAGE 2 публикации, 2.3%
Bentham Science Publishers Ltd.	Bentham Science Publishers Ltd., 1, 1.15% Bentham Science Publishers Ltd. 1 публикация, 1.15%
Impact Journals	Impact Journals, 1, 1.15% Impact Journals 1 публикация, 1.15%
Frontiers Media S.A.	Frontiers Media S.A., 1, 1.15% Frontiers Media S.A. 1 публикация, 1.15%
The Society of Synthetic Organic Chemistry, Japan	The Society of Synthetic Organic Chemistry, Japan, 1, 1.15% The Society of Synthetic Organic Chemistry, Japan 1 публикация, 1.15%
Oxford University Press	Oxford University Press, 1, 1.15% Oxford University Press 1 публикация, 1.15%
De Gruyter Brill	De Gruyter Brill, 1, 1.15% De Gruyter Brill 1 публикация, 1.15%
Cold Spring Harbor Laboratory	Cold Spring Harbor Laboratory, 1, 1.15% Cold Spring Harbor Laboratory 1 публикация, 1.15%
openRxiv	openRxiv, 1, 1.15% openRxiv 1 публикация, 1.15%
MDPI	MDPI, 1, 1.15% MDPI 1 публикация, 1.15%
Autonomous Non-profit Organization Editorial Board of the journal Uspekhi Khimii	Autonomous Non-profit Organization Editorial Board of the journal Uspekhi Khimii, 1, 1.15% Autonomous Non-profit Organization Editorial Board of the journal Uspekhi Khimii 1 публикация, 1.15%
	5 10 15 20 25 30

Мы не учитываем публикации, у которых нет DOI.
Статистика публикаций обновляется еженедельно.

Вы ученый?

Создайте профиль, чтобы получать персональные рекомендации коллег, конференций и новых статей.

Войти с ORCID

Метрики

Цитировать

ГОСТ |

Цитировать

ГОСТ Скопировать

Suzuki T. et al. Identification of the KDM2/7 Histone Lysine Demethylase Subfamily Inhibitor and its Antiproliferative Activity // Journal of Medicinal Chemistry. 2013. Vol. 56. No. 18. pp. 7222-7231.

ГОСТ со всеми авторами (до 50) Скопировать

Suzuki T., Ozasa H., Itoh Y., Zhan P., Sawada H., Mino K., Walport L. J., Ohkubo R., Kawamura A., Yonezawa M., Tsukada Y., Tumber A., NAKAGAWA H., Hasegawa M., SASAKI R., MIZUKAMI T., Schofield C. J., Miyata N. Identification of the KDM2/7 Histone Lysine Demethylase Subfamily Inhibitor and its Antiproliferative Activity // Journal of Medicinal Chemistry. 2013. Vol. 56. No. 18. pp. 7222-7231.

RIS |

Цитировать

RIS Скопировать

TY - JOUR

DO - 10.1021/jm400624b

UR - https://doi.org/10.1021/jm400624b

TI - Identification of the KDM2/7 Histone Lysine Demethylase Subfamily Inhibitor and its Antiproliferative Activity

T2 - Journal of Medicinal Chemistry

AU - Suzuki, Takayoshi

AU - Ozasa, Hiroki

AU - Itoh, Yukihiro

AU - Zhan, Peng

AU - Sawada, Hideyuki

AU - Mino, Koshiki

AU - Walport, Louise J

AU - Ohkubo, Rei

AU - Kawamura, Akane

AU - Yonezawa, Masato

AU - Tsukada, Yuichi

AU - Tumber, Anthony

AU - NAKAGAWA, HIDEHIKO

AU - Hasegawa, Makoto

AU - SASAKI, RYUZO

AU - MIZUKAMI, TAMIO

AU - Schofield, Christopher J.

AU - Miyata, N.

PY - 2013

DA - 2013/09/05

PB - American Chemical Society (ACS)

SP - 7222-7231

IS - 18

VL - 56

PMID - 23964788

SN - 0022-2623

SN - 1520-4804

ER -

BibTex |

Цитировать

BibTex (до 50 авторов) Скопировать

@article{2013_Suzuki,

author = {Takayoshi Suzuki and Hiroki Ozasa and Yukihiro Itoh and Peng Zhan and Hideyuki Sawada and Koshiki Mino and Louise J Walport and Rei Ohkubo and Akane Kawamura and Masato Yonezawa and Yuichi Tsukada and Anthony Tumber and HIDEHIKO NAKAGAWA and Makoto Hasegawa and RYUZO SASAKI and TAMIO MIZUKAMI and Christopher J. Schofield and N. Miyata},

title = {Identification of the KDM2/7 Histone Lysine Demethylase Subfamily Inhibitor and its Antiproliferative Activity},

journal = {Journal of Medicinal Chemistry},

year = {2013},

volume = {56},

publisher = {American Chemical Society (ACS)},

month = {sep},

url = {https://doi.org/10.1021/jm400624b},

number = {18},

pages = {7222--7231},

doi = {10.1021/jm400624b}

}

MLA

Цитировать

MLA Скопировать

Suzuki, Takayoshi, et al. “Identification of the KDM2/7 Histone Lysine Demethylase Subfamily Inhibitor and its Antiproliferative Activity.” Journal of Medicinal Chemistry, vol. 56, no. 18, Sep. 2013, pp. 7222-7231. https://doi.org/10.1021/jm400624b.

Издатель

American Chemical Society (ACS)

Журнал

Journal of Medicinal Chemistry

SCImago Q1

Tоп 10% SCImago

WOS Q1

БС1

SJR

1.726

CiteScore

11.5

Impact factor

6.8

ISSN

00222623 (Print)

15204804 (Electronic)

Ошибка в публикации?