Activity of 2-Aryl-2-(3-indolyl)acetohydroxamates against Drug-Resistant Cancer Cells
Alexander N Smirnov
1
,
Igor V. Magedov
2
,
Mary R Reisenauer
2
,
Inna V. Aksenova
1
,
Alexander L Pendleton
2
,
Gina Nguyen
2
,
Robert K Johnston
2
,
Michael Rubin
3
,
Annelise Carvalho
4
,
Robert Kiss
4
,
VÉRONIQUE MATHIEU
4
,
Florence Lefranc
5
,
Jaime Correa
6
,
David A. Cavazos
7
,
A. Brenner
7
,
BRAD A. BRYAN
8
,
Snezna Rogelj
2
,
Alexander Kornienko
6
,
Liliya V. Frolova
2
Тип публикации: Journal Article
Дата публикации: 2015-02-20
scimago Q1
wos Q1
БС1
SJR: 1.801
CiteScore: 11.5
Impact factor: 6.8
ISSN: 00222623, 15204804
PubMed ID:
25671501
Drug Discovery
Molecular Medicine
Краткое описание
Many types of tumor, including glioma, melanoma, non-small cell lung, esophageal, and head and neck cancer, among others, are intrinsically resistant to apoptosis induction and poorly responsive to current therapies with proapoptotic agents. In addition, tumors often develop multidrug resistance based on the cellular efflux of chemotherapeutic agents. Thus, novel anticancer agents capable of overcoming these intrinsic or developed tumor resistance mechanisms are urgently needed. We describe a series of 2-aryl-2-(3-indolyl)acetohydroxamic acids that are active against apoptosis- and multidrug-resistant cancer cells as well as glioblastoma neurosphere stemlike cell cultures derived from patients. Thus, the described compounds serve as a novel chemical scaffold for the development of potentially highly effective clinical cancer drugs.
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50
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Цитирований c 2024:
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(10%)
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ГОСТ |
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MLA
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ГОСТ
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Aksenov A. et al. Activity of 2-Aryl-2-(3-indolyl)acetohydroxamates against Drug-Resistant Cancer Cells // Journal of Medicinal Chemistry. 2015. Vol. 58. No. 5. pp. 2206-2220.
ГОСТ со всеми авторами (до 50)
Скопировать
Aksenov A., Smirnov A. N., Magedov I. V., Reisenauer M. R., Aksenov N. A., Aksenova I. V., Pendleton A. L., Nguyen G., Johnston R. K., Rubin M., Carvalho A., Kiss R., MATHIEU V., Lefranc F., Correa J., Cavazos D. A., Brenner A., BRYAN B. A., Rogelj S., Kornienko A., Frolova L. V. Activity of 2-Aryl-2-(3-indolyl)acetohydroxamates against Drug-Resistant Cancer Cells // Journal of Medicinal Chemistry. 2015. Vol. 58. No. 5. pp. 2206-2220.
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RIS
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TY - JOUR
DO - 10.1021/jm501518y
UR - https://doi.org/10.1021/jm501518y
TI - Activity of 2-Aryl-2-(3-indolyl)acetohydroxamates against Drug-Resistant Cancer Cells
T2 - Journal of Medicinal Chemistry
AU - Aksenov, Alexander V.
AU - Smirnov, Alexander N
AU - Magedov, Igor V.
AU - Reisenauer, Mary R
AU - Aksenov, Nicolai A.
AU - Aksenova, Inna V.
AU - Pendleton, Alexander L
AU - Nguyen, Gina
AU - Johnston, Robert K
AU - Rubin, Michael
AU - Carvalho, Annelise
AU - Kiss, Robert
AU - MATHIEU, VÉRONIQUE
AU - Lefranc, Florence
AU - Correa, Jaime
AU - Cavazos, David A.
AU - Brenner, A.
AU - BRYAN, BRAD A.
AU - Rogelj, Snezna
AU - Kornienko, Alexander
AU - Frolova, Liliya V.
PY - 2015
DA - 2015/02/20
PB - American Chemical Society (ACS)
SP - 2206-2220
IS - 5
VL - 58
PMID - 25671501
SN - 0022-2623
SN - 1520-4804
ER -
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BibTex (до 50 авторов)
Скопировать
@article{2015_Aksenov,
author = {Alexander V. Aksenov and Alexander N Smirnov and Igor V. Magedov and Mary R Reisenauer and Nicolai A. Aksenov and Inna V. Aksenova and Alexander L Pendleton and Gina Nguyen and Robert K Johnston and Michael Rubin and Annelise Carvalho and Robert Kiss and VÉRONIQUE MATHIEU and Florence Lefranc and Jaime Correa and David A. Cavazos and A. Brenner and BRAD A. BRYAN and Snezna Rogelj and Alexander Kornienko and Liliya V. Frolova},
title = {Activity of 2-Aryl-2-(3-indolyl)acetohydroxamates against Drug-Resistant Cancer Cells},
journal = {Journal of Medicinal Chemistry},
year = {2015},
volume = {58},
publisher = {American Chemical Society (ACS)},
month = {feb},
url = {https://doi.org/10.1021/jm501518y},
number = {5},
pages = {2206--2220},
doi = {10.1021/jm501518y}
}
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MLA
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Aksenov, Alexander V., et al. “Activity of 2-Aryl-2-(3-indolyl)acetohydroxamates against Drug-Resistant Cancer Cells.” Journal of Medicinal Chemistry, vol. 58, no. 5, Feb. 2015, pp. 2206-2220. https://doi.org/10.1021/jm501518y.
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