Activity of 2-Aryl-2-(3-indolyl)acetohydroxamates against Drug-Resistant Cancer Cells
Alexander N Smirnov
1
,
Igor V. Magedov
2
,
Mary R Reisenauer
2
,
Inna V. Aksenova
1
,
Alexander L Pendleton
2
,
Gina Nguyen
2
,
Robert K Johnston
2
,
Michael Rubin
3
,
Annelise Carvalho
4
,
Robert Kiss
4
,
VÉRONIQUE MATHIEU
4
,
Florence Lefranc
5
,
Jaime Correa
6
,
David A. Cavazos
7
,
A. Brenner
7
,
BRAD A. BRYAN
8
,
Snezna Rogelj
2
,
Alexander Kornienko
6
,
Liliya V. Frolova
2
Publication type: Journal Article
Publication date: 2015-02-20
scimago Q1
wos Q1
SJR: 1.801
CiteScore: 11.5
Impact factor: 6.8
ISSN: 00222623, 15204804
PubMed ID:
25671501
Drug Discovery
Molecular Medicine
Abstract
Many types of tumor, including glioma, melanoma, non-small cell lung, esophageal, and head and neck cancer, among others, are intrinsically resistant to apoptosis induction and poorly responsive to current therapies with proapoptotic agents. In addition, tumors often develop multidrug resistance based on the cellular efflux of chemotherapeutic agents. Thus, novel anticancer agents capable of overcoming these intrinsic or developed tumor resistance mechanisms are urgently needed. We describe a series of 2-aryl-2-(3-indolyl)acetohydroxamic acids that are active against apoptosis- and multidrug-resistant cancer cells as well as glioblastoma neurosphere stemlike cell cultures derived from patients. Thus, the described compounds serve as a novel chemical scaffold for the development of potentially highly effective clinical cancer drugs.
Found
Nothing found, try to update filter.
Found
Nothing found, try to update filter.
Top-30
Journals
|
1
2
3
4
5
6
7
|
|
|
RSC Advances
7 publications, 14%
|
|
|
Journal of Organic Chemistry
5 publications, 10%
|
|
|
Chemistry of Heterocyclic Compounds
4 publications, 8%
|
|
|
European Journal of Medicinal Chemistry
4 publications, 8%
|
|
|
Molecules
3 publications, 6%
|
|
|
Tetrahedron Letters
3 publications, 6%
|
|
|
Medicinal Chemistry Research
2 publications, 4%
|
|
|
ChemMedChem
2 publications, 4%
|
|
|
Journal of Medicinal Chemistry
2 publications, 4%
|
|
|
Chemical Communications
2 publications, 4%
|
|
|
Russian Journal of Organic Chemistry
1 publication, 2%
|
|
|
Mendeleev Communications
1 publication, 2%
|
|
|
MolBank
1 publication, 2%
|
|
|
Investigational New Drugs
1 publication, 2%
|
|
|
iScience
1 publication, 2%
|
|
|
Tetrahedron
1 publication, 2%
|
|
|
Organic and Biomolecular Chemistry
1 publication, 2%
|
|
|
Journal of Biomolecular Structure and Dynamics
1 publication, 2%
|
|
|
Synthetic Communications
1 publication, 2%
|
|
|
IEEE Transactions on Biomedical Engineering
1 publication, 2%
|
|
|
Russian Chemical Bulletin
1 publication, 2%
|
|
|
Synlett
1 publication, 2%
|
|
|
Bioorganic and Medicinal Chemistry Letters
1 publication, 2%
|
|
|
Russian Chemical Reviews
1 publication, 2%
|
|
|
Organic Letters
1 publication, 2%
|
|
|
1
2
3
4
5
6
7
|
Publishers
|
2
4
6
8
10
|
|
|
Royal Society of Chemistry (RSC)
10 publications, 20%
|
|
|
Elsevier
10 publications, 20%
|
|
|
Springer Nature
8 publications, 16%
|
|
|
American Chemical Society (ACS)
8 publications, 16%
|
|
|
MDPI
4 publications, 8%
|
|
|
Wiley
3 publications, 6%
|
|
|
Taylor & Francis
2 publications, 4%
|
|
|
Pleiades Publishing
1 publication, 2%
|
|
|
OOO Zhurnal "Mendeleevskie Soobshcheniya"
1 publication, 2%
|
|
|
Institute of Electrical and Electronics Engineers (IEEE)
1 publication, 2%
|
|
|
Georg Thieme Verlag KG
1 publication, 2%
|
|
|
Autonomous Non-profit Organization Editorial Board of the journal Uspekhi Khimii
1 publication, 2%
|
|
|
2
4
6
8
10
|
- We do not take into account publications without a DOI.
- Statistics recalculated weekly.
Are you a researcher?
Create a profile to get free access to personal recommendations for colleagues and new articles.
Metrics
50
Total citations:
50
Citations from 2024:
5
(10%)
Cite this
GOST |
RIS |
BibTex |
MLA
Cite this
GOST
Copy
Aksenov A. et al. Activity of 2-Aryl-2-(3-indolyl)acetohydroxamates against Drug-Resistant Cancer Cells // Journal of Medicinal Chemistry. 2015. Vol. 58. No. 5. pp. 2206-2220.
GOST all authors (up to 50)
Copy
Aksenov A., Smirnov A. N., Magedov I. V., Reisenauer M. R., Aksenov N. A., Aksenova I. V., Pendleton A. L., Nguyen G., Johnston R. K., Rubin M., Carvalho A., Kiss R., MATHIEU V., Lefranc F., Correa J., Cavazos D. A., Brenner A., BRYAN B. A., Rogelj S., Kornienko A., Frolova L. V. Activity of 2-Aryl-2-(3-indolyl)acetohydroxamates against Drug-Resistant Cancer Cells // Journal of Medicinal Chemistry. 2015. Vol. 58. No. 5. pp. 2206-2220.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1021/jm501518y
UR - https://doi.org/10.1021/jm501518y
TI - Activity of 2-Aryl-2-(3-indolyl)acetohydroxamates against Drug-Resistant Cancer Cells
T2 - Journal of Medicinal Chemistry
AU - Aksenov, Alexander V.
AU - Smirnov, Alexander N
AU - Magedov, Igor V.
AU - Reisenauer, Mary R
AU - Aksenov, Nicolai A.
AU - Aksenova, Inna V.
AU - Pendleton, Alexander L
AU - Nguyen, Gina
AU - Johnston, Robert K
AU - Rubin, Michael
AU - Carvalho, Annelise
AU - Kiss, Robert
AU - MATHIEU, VÉRONIQUE
AU - Lefranc, Florence
AU - Correa, Jaime
AU - Cavazos, David A.
AU - Brenner, A.
AU - BRYAN, BRAD A.
AU - Rogelj, Snezna
AU - Kornienko, Alexander
AU - Frolova, Liliya V.
PY - 2015
DA - 2015/02/20
PB - American Chemical Society (ACS)
SP - 2206-2220
IS - 5
VL - 58
PMID - 25671501
SN - 0022-2623
SN - 1520-4804
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2015_Aksenov,
author = {Alexander V. Aksenov and Alexander N Smirnov and Igor V. Magedov and Mary R Reisenauer and Nicolai A. Aksenov and Inna V. Aksenova and Alexander L Pendleton and Gina Nguyen and Robert K Johnston and Michael Rubin and Annelise Carvalho and Robert Kiss and VÉRONIQUE MATHIEU and Florence Lefranc and Jaime Correa and David A. Cavazos and A. Brenner and BRAD A. BRYAN and Snezna Rogelj and Alexander Kornienko and Liliya V. Frolova},
title = {Activity of 2-Aryl-2-(3-indolyl)acetohydroxamates against Drug-Resistant Cancer Cells},
journal = {Journal of Medicinal Chemistry},
year = {2015},
volume = {58},
publisher = {American Chemical Society (ACS)},
month = {feb},
url = {https://doi.org/10.1021/jm501518y},
number = {5},
pages = {2206--2220},
doi = {10.1021/jm501518y}
}
Cite this
MLA
Copy
Aksenov, Alexander V., et al. “Activity of 2-Aryl-2-(3-indolyl)acetohydroxamates against Drug-Resistant Cancer Cells.” Journal of Medicinal Chemistry, vol. 58, no. 5, Feb. 2015, pp. 2206-2220. https://doi.org/10.1021/jm501518y.