Cdc7 Kinase Inhibitors: Pyrrolopyridinones as Potential Antitumor Agents. 1. Synthesis and Structure–Activity Relationships
Тип публикации: Journal Article
Дата публикации: 2008-01-18
scimago Q1
wos Q1
БС1
SJR: 1.801
CiteScore: 11.5
Impact factor: 6.8
ISSN: 00222623, 15204804
PubMed ID:
18201066
Drug Discovery
Molecular Medicine
Краткое описание
Cdc7 kinase is an essential protein that promotes DNA replication in eukaryotic organisms. Genetic evidence indicates that Cdc7 inhibition can cause selective tumor-cell death in a p53-independent manner, supporting the rationale for developing Cdc7 small-molecule inhibitors for the treatment of cancers. In this paper, the synthesis and structure–activity relationships of 2-heteroaryl-pyrrolopyridinones, the first potent Cdc7 kinase inhibitors, are described. Starting from 2-pyridin-4-yl-1,5,6,7-tetrahydro-pyrrolo[3,2-c]pyridin-4-one, progress toward a simple scaffold, tailored for Cdc7 inhibition, is reported.
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Vanotti E. et al. Cdc7 Kinase Inhibitors: Pyrrolopyridinones as Potential Antitumor Agents. 1. Synthesis and Structure–Activity Relationships // Journal of Medicinal Chemistry. 2008. Vol. 51. No. 3. pp. 487-501.
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Vanotti E., Amici R., Bargiotti A., Berthelsen J., Bosotti R., Ciavolella A., Cirla A., Cristiani C., D’Alessio R., Forte B., Isacchi A., Martina K., Menichincheri M., MOLINARI A., Montagnoli A., Orsini P., Pillan A., Roletto F., Scolaro A., Tibolla M., VALSASINA B., Varasi M., Volpi D., Santocanale C. Cdc7 Kinase Inhibitors: Pyrrolopyridinones as Potential Antitumor Agents. 1. Synthesis and Structure–Activity Relationships // Journal of Medicinal Chemistry. 2008. Vol. 51. No. 3. pp. 487-501.
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TY - JOUR
DO - 10.1021/jm700956r
UR - https://doi.org/10.1021/jm700956r
TI - Cdc7 Kinase Inhibitors: Pyrrolopyridinones as Potential Antitumor Agents. 1. Synthesis and Structure–Activity Relationships
T2 - Journal of Medicinal Chemistry
AU - Vanotti, Ermes
AU - Amici, Raffaella
AU - Bargiotti, Alberto
AU - Berthelsen, Jens
AU - Bosotti, Roberta
AU - Ciavolella, Antonella
AU - Cirla, Alessandra
AU - Cristiani, Cinzia
AU - D’Alessio, Roberto
AU - Forte, Barbara
AU - Isacchi, Antonella
AU - Martina, K.
AU - Menichincheri, Maria
AU - MOLINARI, Antonio
AU - Montagnoli, Alessia
AU - Orsini, Paolo
AU - Pillan, Antonio
AU - Roletto, Fulvia
AU - Scolaro, Alessandra
AU - Tibolla, Marcellino
AU - VALSASINA, Barbara
AU - Varasi, Mario
AU - Volpi, Daniele
AU - Santocanale, Corrado
PY - 2008
DA - 2008/01/18
PB - American Chemical Society (ACS)
SP - 487-501
IS - 3
VL - 51
PMID - 18201066
SN - 0022-2623
SN - 1520-4804
ER -
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@article{2008_Vanotti,
author = {Ermes Vanotti and Raffaella Amici and Alberto Bargiotti and Jens Berthelsen and Roberta Bosotti and Antonella Ciavolella and Alessandra Cirla and Cinzia Cristiani and Roberto D’Alessio and Barbara Forte and Antonella Isacchi and K. Martina and Maria Menichincheri and Antonio MOLINARI and Alessia Montagnoli and Paolo Orsini and Antonio Pillan and Fulvia Roletto and Alessandra Scolaro and Marcellino Tibolla and Barbara VALSASINA and Mario Varasi and Daniele Volpi and Corrado Santocanale},
title = {Cdc7 Kinase Inhibitors: Pyrrolopyridinones as Potential Antitumor Agents. 1. Synthesis and Structure–Activity Relationships},
journal = {Journal of Medicinal Chemistry},
year = {2008},
volume = {51},
publisher = {American Chemical Society (ACS)},
month = {jan},
url = {https://doi.org/10.1021/jm700956r},
number = {3},
pages = {487--501},
doi = {10.1021/jm700956r}
}
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MLA
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Vanotti, Ermes, et al. “Cdc7 Kinase Inhibitors: Pyrrolopyridinones as Potential Antitumor Agents. 1. Synthesis and Structure–Activity Relationships.” Journal of Medicinal Chemistry, vol. 51, no. 3, Jan. 2008, pp. 487-501. https://doi.org/10.1021/jm700956r.