том 50 издание 23 страницы 5568-5570

Irreversible Inhibition of Dipeptidyl Peptidase 8 by Dipeptide-Derived Diaryl Phosphonates

Тип публикацииJournal Article
Дата публикации2007-10-24
scimago Q1
wos Q1
БС1
SJR1.801
CiteScore11.5
Impact factor6.8
ISSN00222623, 15204804
Drug Discovery
Molecular Medicine
Краткое описание
Dipeptide-derived compounds, bearing various P2 residues and a diaryl pyrrolidin-2-yl phosphonate at the P1 position, were evaluated as dipeptidyl peptidase 8 (DPP8) inhibitors. With these products, irreversible inhibition of DPP8 was observed. To obtain inhibitors with an improved activity and selectivity profile, a set of selected analogues containing a diaryl isoindolin-1-ylphosphonate at P1 was synthesized and evaluated. Within this latter series, compound 2e was shown to be a potent, irreversible inhibitor of DPP8, demonstrating very low affinity for DPP IV and DPP II.
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ГОСТ |
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VEKEN P. V. D. et al. Irreversible Inhibition of Dipeptidyl Peptidase 8 by Dipeptide-Derived Diaryl Phosphonates // Journal of Medicinal Chemistry. 2007. Vol. 50. No. 23. pp. 5568-5570.
ГОСТ со всеми авторами (до 50) Скопировать
VEKEN P. V. D., Soroka A., Brandt I., Chen Y., Maes M. B., Lambeir A., Chen X., Haemers A., Scharpé S., Augustyns K., De Meester I. Irreversible Inhibition of Dipeptidyl Peptidase 8 by Dipeptide-Derived Diaryl Phosphonates // Journal of Medicinal Chemistry. 2007. Vol. 50. No. 23. pp. 5568-5570.
RIS |
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TY - JOUR
DO - 10.1021/jm701005a
UR - https://doi.org/10.1021/jm701005a
TI - Irreversible Inhibition of Dipeptidyl Peptidase 8 by Dipeptide-Derived Diaryl Phosphonates
T2 - Journal of Medicinal Chemistry
AU - VEKEN, P VAN DER
AU - Soroka, Anna
AU - Brandt, Inger
AU - Chen, Yuan-Shou
AU - Maes, Marie Berthe
AU - Lambeir, Anne-Marie
AU - Chen, Xin
AU - Haemers, Achiel
AU - Scharpé, Simon
AU - Augustyns, Koen
AU - De Meester, Ingrid
PY - 2007
DA - 2007/10/24
PB - American Chemical Society (ACS)
SP - 5568-5570
IS - 23
VL - 50
PMID - 17958345
SN - 0022-2623
SN - 1520-4804
ER -
BibTex |
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BibTex (до 50 авторов) Скопировать
@article{2007_VEKEN,
author = {P VAN DER VEKEN and Anna Soroka and Inger Brandt and Yuan-Shou Chen and Marie Berthe Maes and Anne-Marie Lambeir and Xin Chen and Achiel Haemers and Simon Scharpé and Koen Augustyns and Ingrid De Meester},
title = {Irreversible Inhibition of Dipeptidyl Peptidase 8 by Dipeptide-Derived Diaryl Phosphonates},
journal = {Journal of Medicinal Chemistry},
year = {2007},
volume = {50},
publisher = {American Chemical Society (ACS)},
month = {oct},
url = {https://doi.org/10.1021/jm701005a},
number = {23},
pages = {5568--5570},
doi = {10.1021/jm701005a}
}
MLA
Цитировать
VEKEN, P. VAN DER, et al. “Irreversible Inhibition of Dipeptidyl Peptidase 8 by Dipeptide-Derived Diaryl Phosphonates.” Journal of Medicinal Chemistry, vol. 50, no. 23, Oct. 2007, pp. 5568-5570. https://doi.org/10.1021/jm701005a.