New Antitumor Imidazo[2,1-b]thiazole Guanylhydrazones and Analogues1
Aldo Andreani
1
,
Silvia Burnelli
1
,
Massimiliano Granaiola
1
,
Alberto Leoni
1
,
Alessandra Locatelli
1
,
Rita Morigi
1
,
Mirella Rambaldi
1
,
Lucilla Varoli
1
,
Natalia Calonghi
1
,
Concettina Cappadone
1
,
Giovanna Farruggia
1
,
Maddalena ZINI
1
,
Claudio Stefanelli
1
,
Lanfranco Masotti
1
,
Norman S. Radin
1
,
Robert H. Shoemaker
1
Publication type: Journal Article
Publication date: 2008-02-01
scimago Q1
wos Q1
SJR: 1.801
CiteScore: 11.5
Impact factor: 6.8
ISSN: 00222623, 15204804
PubMed ID:
18251494
Drug Discovery
Molecular Medicine
Abstract
The synthesis of new antitumor 6-substituted imidazothiazole guanylhydrazones is described. Moreover, a series of compounds with a different basic chain at the 5 position were prepared. Finally, the replacement of the thiazole ring in the imidazothiazole system was also considered. All the new compounds prepared were submitted to the NCI cell line screen for evaluation of their antitumor activity. A few selected compounds were submitted to additional biological studies concerning effects on the cell cycle, apoptosis, and mitochondria.
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Metrics
142
Total citations:
142
Citations from 2025:
9
(6.34%)
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MLA
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GOST
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Andreani A. et al. New Antitumor Imidazo[2,1-b]thiazole Guanylhydrazones and Analogues1 // Journal of Medicinal Chemistry. 2008. Vol. 51. No. 4. pp. 809-816.
GOST all authors (up to 50)
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Andreani A., Burnelli S., Granaiola M., Leoni A., Locatelli A., Morigi R., Rambaldi M., Varoli L., Calonghi N., Cappadone C., Farruggia G., ZINI M., Stefanelli C., Masotti L., Radin N. S., Shoemaker R. H. New Antitumor Imidazo[2,1-b]thiazole Guanylhydrazones and Analogues1 // Journal of Medicinal Chemistry. 2008. Vol. 51. No. 4. pp. 809-816.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1021/jm701246g
UR - https://doi.org/10.1021/jm701246g
TI - New Antitumor Imidazo[2,1-b]thiazole Guanylhydrazones and Analogues1
T2 - Journal of Medicinal Chemistry
AU - Andreani, Aldo
AU - Burnelli, Silvia
AU - Granaiola, Massimiliano
AU - Leoni, Alberto
AU - Locatelli, Alessandra
AU - Morigi, Rita
AU - Rambaldi, Mirella
AU - Varoli, Lucilla
AU - Calonghi, Natalia
AU - Cappadone, Concettina
AU - Farruggia, Giovanna
AU - ZINI, Maddalena
AU - Stefanelli, Claudio
AU - Masotti, Lanfranco
AU - Radin, Norman S.
AU - Shoemaker, Robert H.
PY - 2008
DA - 2008/02/01
PB - American Chemical Society (ACS)
SP - 809-816
IS - 4
VL - 51
PMID - 18251494
SN - 0022-2623
SN - 1520-4804
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2008_Andreani,
author = {Aldo Andreani and Silvia Burnelli and Massimiliano Granaiola and Alberto Leoni and Alessandra Locatelli and Rita Morigi and Mirella Rambaldi and Lucilla Varoli and Natalia Calonghi and Concettina Cappadone and Giovanna Farruggia and Maddalena ZINI and Claudio Stefanelli and Lanfranco Masotti and Norman S. Radin and Robert H. Shoemaker},
title = {New Antitumor Imidazo[2,1-b]thiazole Guanylhydrazones and Analogues1},
journal = {Journal of Medicinal Chemistry},
year = {2008},
volume = {51},
publisher = {American Chemical Society (ACS)},
month = {feb},
url = {https://doi.org/10.1021/jm701246g},
number = {4},
pages = {809--816},
doi = {10.1021/jm701246g}
}
Cite this
MLA
Copy
Andreani, Aldo, et al. “New Antitumor Imidazo[2,1-b]thiazole Guanylhydrazones and Analogues1.” Journal of Medicinal Chemistry, vol. 51, no. 4, Feb. 2008, pp. 809-816. https://doi.org/10.1021/jm701246g.