Antitumor Activity of New Substituted 3-(5-Imidazo[2,1-b]thiazolylmethylene)-2-indolinones and 3-(5-Imidazo[2,1-b]thiadiazolylmethylene)-2-indolinones: Selectivity against Colon Tumor Cells and Effect on Cell Cycle-Related Events
Тип публикации: Journal Article
Дата публикации: 2008-11-12
scimago Q1
wos Q1
БС1
SJR: 1.801
CiteScore: 11.5
Impact factor: 6.8
ISSN: 00222623, 15204804
PubMed ID:
19006285
Drug Discovery
Molecular Medicine
Краткое описание
The synthesis of new 3-(5-imidazo[2,1-b]thiazolylmethylene)-2-indolinones and 3-(5-imidazo[2,1-b]thiadiazolylmethylene)-2-indolinones is reported. The antitumor activity was evaluated according to the protocols available at the National Cancer Institute (NCI), Bethesda, MD. To investigate the mechanism of action of the most potent antitumor agent of this series, its effect on growth of HT-29 colon carcinoma cells was studied. Its ability to inhibit cellular proliferation was mediated by cell cycle arrest at the G2/M phase, accompanied by inhibition of ornithine decarboxylase (ODC), the limiting enzyme of polyamine synthesis, and followed by induction of apoptosis.
Найдено
Ничего не найдено, попробуйте изменить настройки фильтра.
Для доступа к списку цитирований публикации необходимо авторизоваться.
Топ-30
Журналы
|
1
2
3
4
|
|
|
Journal of Heterocyclic Chemistry
4 публикации, 5.97%
|
|
|
Organic and Biomolecular Chemistry
4 публикации, 5.97%
|
|
|
RSC Advances
4 публикации, 5.97%
|
|
|
Medicinal Chemistry Research
3 публикации, 4.48%
|
|
|
Tetrahedron
3 публикации, 4.48%
|
|
|
Organic Letters
3 публикации, 4.48%
|
|
|
Molecules
2 публикации, 2.99%
|
|
|
Bioorganic and Medicinal Chemistry
2 публикации, 2.99%
|
|
|
Bioorganic Chemistry
2 публикации, 2.99%
|
|
|
Tetrahedron Letters
2 публикации, 2.99%
|
|
|
ChemistrySelect
2 публикации, 2.99%
|
|
|
ChemMedChem
2 публикации, 2.99%
|
|
|
Journal of Organic Chemistry
2 публикации, 2.99%
|
|
|
MedChemComm
2 публикации, 2.99%
|
|
|
Beilstein Journal of Organic Chemistry
1 публикация, 1.49%
|
|
|
Current Medicinal Chemistry
1 публикация, 1.49%
|
|
|
Current Green Chemistry
1 публикация, 1.49%
|
|
|
Journal of Biomolecular Structure and Dynamics
1 публикация, 1.49%
|
|
|
Pharmaceutical Research
1 публикация, 1.49%
|
|
|
Research on Chemical Intermediates
1 публикация, 1.49%
|
|
|
Molecular Diversity
1 публикация, 1.49%
|
|
|
Pharmaceutical Chemistry Journal
1 публикация, 1.49%
|
|
|
Journal of Molecular Structure
1 публикация, 1.49%
|
|
|
Biochemical and Biophysical Research Communications
1 публикация, 1.49%
|
|
|
European Journal of Medicinal Chemistry
1 публикация, 1.49%
|
|
|
Heliyon
1 публикация, 1.49%
|
|
|
Mendeleev Communications
1 публикация, 1.49%
|
|
|
Arabian Journal of Chemistry
1 публикация, 1.49%
|
|
|
Materials Today Chemistry
1 публикация, 1.49%
|
|
|
1
2
3
4
|
Издатели
|
2
4
6
8
10
12
14
16
18
|
|
|
Elsevier
17 публикаций, 25.37%
|
|
|
Royal Society of Chemistry (RSC)
12 публикаций, 17.91%
|
|
|
Wiley
11 публикаций, 16.42%
|
|
|
Springer Nature
7 публикаций, 10.45%
|
|
|
American Chemical Society (ACS)
7 публикаций, 10.45%
|
|
|
Bentham Science Publishers Ltd.
3 публикации, 4.48%
|
|
|
Taylor & Francis
2 публикации, 2.99%
|
|
|
MDPI
2 публикации, 2.99%
|
|
|
Beilstein-Institut
1 публикация, 1.49%
|
|
|
OOO Zhurnal "Mendeleevskie Soobshcheniya"
1 публикация, 1.49%
|
|
|
King Saud University
1 публикация, 1.49%
|
|
|
Pleiades Publishing
1 публикация, 1.49%
|
|
|
The Japan Institute of Heterocyclic Chemistry
1 публикация, 1.49%
|
|
|
2
4
6
8
10
12
14
16
18
|
- Мы не учитываем публикации, у которых нет DOI.
- Статистика публикаций обновляется еженедельно.
Вы ученый?
Создайте профиль, чтобы получать персональные рекомендации коллег, конференций и новых статей.
Метрики
67
Всего цитирований:
67
Цитирований c 2025:
3
(4.48%)
Цитировать
ГОСТ |
RIS |
BibTex |
MLA
Цитировать
ГОСТ
Скопировать
Andreani A. et al. Antitumor Activity of New Substituted 3-(5-Imidazo[2,1-b]thiazolylmethylene)-2-indolinones and 3-(5-Imidazo[2,1-b]thiadiazolylmethylene)-2-indolinones: Selectivity against Colon Tumor Cells and Effect on Cell Cycle-Related Events // Journal of Medicinal Chemistry. 2008. Vol. 51. No. 23. pp. 7508-7513.
ГОСТ со всеми авторами (до 50)
Скопировать
Andreani A., Burnelli S., Granaiola M., Leoni A., Locatelli A., Morigi R., Rambaldi M., Varoli L., Calonghi N., Cappadone C., Voltattorni M., ZINI M., Stefanelli C., Masotti L., Shoemaker R. H. Antitumor Activity of New Substituted 3-(5-Imidazo[2,1-b]thiazolylmethylene)-2-indolinones and 3-(5-Imidazo[2,1-b]thiadiazolylmethylene)-2-indolinones: Selectivity against Colon Tumor Cells and Effect on Cell Cycle-Related Events // Journal of Medicinal Chemistry. 2008. Vol. 51. No. 23. pp. 7508-7513.
Цитировать
RIS
Скопировать
TY - JOUR
DO - 10.1021/jm800827q
UR - https://doi.org/10.1021/jm800827q
TI - Antitumor Activity of New Substituted 3-(5-Imidazo[2,1-b]thiazolylmethylene)-2-indolinones and 3-(5-Imidazo[2,1-b]thiadiazolylmethylene)-2-indolinones: Selectivity against Colon Tumor Cells and Effect on Cell Cycle-Related Events
T2 - Journal of Medicinal Chemistry
AU - Andreani, Aldo
AU - Burnelli, Silvia
AU - Granaiola, Massimiliano
AU - Leoni, Alberto
AU - Locatelli, Alessandra
AU - Morigi, Rita
AU - Rambaldi, Mirella
AU - Varoli, Lucilla
AU - Calonghi, Natalia
AU - Cappadone, C
AU - Voltattorni, Manuela
AU - ZINI, Maddalena
AU - Stefanelli, Claudio
AU - Masotti, Lanfranco
AU - Shoemaker, Robert H.
PY - 2008
DA - 2008/11/12
PB - American Chemical Society (ACS)
SP - 7508-7513
IS - 23
VL - 51
PMID - 19006285
SN - 0022-2623
SN - 1520-4804
ER -
Цитировать
BibTex (до 50 авторов)
Скопировать
@article{2008_Andreani,
author = {Aldo Andreani and Silvia Burnelli and Massimiliano Granaiola and Alberto Leoni and Alessandra Locatelli and Rita Morigi and Mirella Rambaldi and Lucilla Varoli and Natalia Calonghi and C Cappadone and Manuela Voltattorni and Maddalena ZINI and Claudio Stefanelli and Lanfranco Masotti and Robert H. Shoemaker},
title = {Antitumor Activity of New Substituted 3-(5-Imidazo[2,1-b]thiazolylmethylene)-2-indolinones and 3-(5-Imidazo[2,1-b]thiadiazolylmethylene)-2-indolinones: Selectivity against Colon Tumor Cells and Effect on Cell Cycle-Related Events},
journal = {Journal of Medicinal Chemistry},
year = {2008},
volume = {51},
publisher = {American Chemical Society (ACS)},
month = {nov},
url = {https://doi.org/10.1021/jm800827q},
number = {23},
pages = {7508--7513},
doi = {10.1021/jm800827q}
}
Цитировать
MLA
Скопировать
Andreani, Aldo, et al. “Antitumor Activity of New Substituted 3-(5-Imidazo[2,1-b]thiazolylmethylene)-2-indolinones and 3-(5-Imidazo[2,1-b]thiadiazolylmethylene)-2-indolinones: Selectivity against Colon Tumor Cells and Effect on Cell Cycle-Related Events.” Journal of Medicinal Chemistry, vol. 51, no. 23, Nov. 2008, pp. 7508-7513. https://doi.org/10.1021/jm800827q.