Polymer−Drug Conjugates for Combination Anticancer Therapy: Investigating the Mechanism of Action
Тип публикации: Journal Article
Дата публикации: 2009-09-18
scimago Q1
wos Q1
БС1
SJR: 1.801
CiteScore: 11.5
Impact factor: 6.8
ISSN: 00222623, 15204804
PubMed ID:
19764729
Drug Discovery
Molecular Medicine
Краткое описание
We developed a family of polymer-drug conjugates carrying the combination of the anticancer agent epirubicin (EPI) and nitric oxide (NO). EPI-PEG-(NO)8, carrying the highest content of NO, displayed greater activity in Caco-2 cells while it decreased toxicity against endothelium cells and cardiomyocytes with respect to free EPI. FACS and confocal microscopy confirmed conjugates internalization. Light scattering showed formation of micelle whose size correlated with internalization rate. EPI-PEG-(NO)8 showed increased bioavailability in mice compared to free EPI.
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Всего цитирований:
40
Цитирований c 2025:
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ГОСТ |
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BibTex |
MLA
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ГОСТ
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Pasut G. et al. Polymer−Drug Conjugates for Combination Anticancer Therapy: Investigating the Mechanism of Action // Journal of Medicinal Chemistry. 2009. Vol. 52. No. 20. pp. 6499-6502.
ГОСТ со всеми авторами (до 50)
Скопировать
Pasut G., Greco F. G., Mero A., Mendichi R., Fante C., Green R. J., Veronese F. M. Polymer−Drug Conjugates for Combination Anticancer Therapy: Investigating the Mechanism of Action // Journal of Medicinal Chemistry. 2009. Vol. 52. No. 20. pp. 6499-6502.
Цитировать
RIS
Скопировать
TY - JOUR
DO - 10.1021/jm900804m
UR - https://doi.org/10.1021/jm900804m
TI - Polymer−Drug Conjugates for Combination Anticancer Therapy: Investigating the Mechanism of Action
T2 - Journal of Medicinal Chemistry
AU - Pasut, Gianfranco
AU - Greco, Francesca G
AU - Mero, Anna
AU - Mendichi, Raniero
AU - Fante, Cristina
AU - Green, Rebecca J.
AU - Veronese, Francesco M.
PY - 2009
DA - 2009/09/18
PB - American Chemical Society (ACS)
SP - 6499-6502
IS - 20
VL - 52
PMID - 19764729
SN - 0022-2623
SN - 1520-4804
ER -
Цитировать
BibTex (до 50 авторов)
Скопировать
@article{2009_Pasut,
author = {Gianfranco Pasut and Francesca G Greco and Anna Mero and Raniero Mendichi and Cristina Fante and Rebecca J. Green and Francesco M. Veronese},
title = {Polymer−Drug Conjugates for Combination Anticancer Therapy: Investigating the Mechanism of Action},
journal = {Journal of Medicinal Chemistry},
year = {2009},
volume = {52},
publisher = {American Chemical Society (ACS)},
month = {sep},
url = {https://doi.org/10.1021/jm900804m},
number = {20},
pages = {6499--6502},
doi = {10.1021/jm900804m}
}
Цитировать
MLA
Скопировать
Pasut, Gianfranco, et al. “Polymer−Drug Conjugates for Combination Anticancer Therapy: Investigating the Mechanism of Action.” Journal of Medicinal Chemistry, vol. 52, no. 20, Sep. 2009, pp. 6499-6502. https://doi.org/10.1021/jm900804m.