Nucleosides and Nucleotides. 185. Synthesis and Biological Activities of 4‘α-C-Branched-Chain Sugar Pyrimidine Nucleosides
Тип публикации: Journal Article
Дата публикации: 1999-07-01
scimago Q1
wos Q1
БС1
SJR: 1.801
CiteScore: 11.5
Impact factor: 6.8
ISSN: 00222623, 15204804
PubMed ID:
10425099
Drug Discovery
Molecular Medicine
Краткое описание
A series of 4'alpha-C-branched-chain pyrimidine nucleosides was synthesized from 2'-deoxycytidine or uridine. In the 2'-deoxycytidine series, the substituent at the 4'alpha-position affected cytotoxicity against L1210 mouse leukemic cells in vitro in the order Me (23) > CN (22) > C(symbol)CH (21) > CH=CH(2) (19) > Et (24) > CH=CHCl (20). However, uridine and cytidine derivatives with ethynyl and cyano groups at the 4'alpha-position did not show any cytotoxicity. The antiviral activities of these nucleosides against HSV-1, HSV-2, and HIV-1 in vitro were also examined. Compounds 22 and 23 showed antiviral activities against HSV-1 and HSV-2 without showing significant toxicity to the host cells (MRC-5 cells). Although almost all of the nucleosides showed anti-HIV-1 activities, they were also cytotoxic to the host cells (MT-4).
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ГОСТ
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Nomura M. et al. Nucleosides and Nucleotides. 185. Synthesis and Biological Activities of 4‘α-C-Branched-Chain Sugar Pyrimidine Nucleosides // Journal of Medicinal Chemistry. 1999. Vol. 42. No. 15. pp. 2901-2908.
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Nomura M., Shuto S., Tanaka M., Sasaki T., Mori S., Shigeta S., Matsuda A. Nucleosides and Nucleotides. 185. Synthesis and Biological Activities of 4‘α-C-Branched-Chain Sugar Pyrimidine Nucleosides // Journal of Medicinal Chemistry. 1999. Vol. 42. No. 15. pp. 2901-2908.
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TY - JOUR
DO - 10.1021/jm990050i
UR - https://pubs.acs.org/doi/10.1021/jm990050i
TI - Nucleosides and Nucleotides. 185. Synthesis and Biological Activities of 4‘α-C-Branched-Chain Sugar Pyrimidine Nucleosides
T2 - Journal of Medicinal Chemistry
AU - Nomura, Makoto
AU - Shuto, Satoshi
AU - Tanaka, Motohiro
AU - Sasaki, Takuma
AU - Mori, S
AU - Shigeta, Shiro
AU - Matsuda, Akira
PY - 1999
DA - 1999/07/01
PB - American Chemical Society (ACS)
SP - 2901-2908
IS - 15
VL - 42
PMID - 10425099
SN - 0022-2623
SN - 1520-4804
ER -
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BibTex (до 50 авторов)
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@article{1999_Nomura,
author = {Makoto Nomura and Satoshi Shuto and Motohiro Tanaka and Takuma Sasaki and S Mori and Shiro Shigeta and Akira Matsuda},
title = {Nucleosides and Nucleotides. 185. Synthesis and Biological Activities of 4‘α-C-Branched-Chain Sugar Pyrimidine Nucleosides},
journal = {Journal of Medicinal Chemistry},
year = {1999},
volume = {42},
publisher = {American Chemical Society (ACS)},
month = {jul},
url = {https://pubs.acs.org/doi/10.1021/jm990050i},
number = {15},
pages = {2901--2908},
doi = {10.1021/jm990050i}
}
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MLA
Скопировать
Nomura, Makoto, et al. “Nucleosides and Nucleotides. 185. Synthesis and Biological Activities of 4‘α-C-Branched-Chain Sugar Pyrimidine Nucleosides.” Journal of Medicinal Chemistry, vol. 42, no. 15, Jul. 1999, pp. 2901-2908. https://pubs.acs.org/doi/10.1021/jm990050i.