Antimalarial, antiproliferative, and antitumor activities of artemisinin-derived, chemically robust, trioxane dimers.
Тип публикации: Journal Article
Дата публикации: 1999-09-30
scimago Q1
wos Q1
БС1
SJR: 1.801
CiteScore: 11.5
Impact factor: 6.8
ISSN: 00222623, 15204804
PubMed ID:
10543871
Drug Discovery
Molecular Medicine
Краткое описание
Nine C-10 non-acetal derivatives of the natural trioxane artemisinin (1) were prepared as dimers using some novel chemistry. As designed, each dimer was stable chemically. C-10 Olefinic dimers 7 and C-10 saturated dimers 8-13 all showed good to excellent antimalarial and antiproliferative activities in vitro. Dimers 8, 10, and 12 were especially potent and selective at inhibiting growth of some human cancer cell lines in the NCI in vitro 60-cell line assay.
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Метрики
107
Всего цитирований:
107
Цитирований c 2025:
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(0.93%)
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ГОСТ |
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MLA
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ГОСТ
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Posner G. H. et al. Antimalarial, antiproliferative, and antitumor activities of artemisinin-derived, chemically robust, trioxane dimers. // Journal of Medicinal Chemistry. 1999. Vol. 42. No. 21. pp. 4275-4280.
ГОСТ со всеми авторами (до 50)
Скопировать
Posner G. H., Ploypradith P., Parker M. H., Odowd H., Woo S., Northrop J., Krasavin M., Dolan P. T., Kensler T. W., Xie S., Shapiro T. A. Antimalarial, antiproliferative, and antitumor activities of artemisinin-derived, chemically robust, trioxane dimers. // Journal of Medicinal Chemistry. 1999. Vol. 42. No. 21. pp. 4275-4280.
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RIS
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TY - JOUR
DO - 10.1021/jm990363d
UR - https://pubs.acs.org/doi/10.1021/jm990363d
TI - Antimalarial, antiproliferative, and antitumor activities of artemisinin-derived, chemically robust, trioxane dimers.
T2 - Journal of Medicinal Chemistry
AU - Posner, Gary H.
AU - Ploypradith, Poonsakdi
AU - Parker, Michael H
AU - Odowd, Hardwin
AU - Woo, Soon-Hyung
AU - Northrop, John
AU - Krasavin, Mikhail
AU - Dolan, Patrick T
AU - Kensler, Thomas W.
AU - Xie, Suji
AU - Shapiro, Theresa A
PY - 1999
DA - 1999/09/30
PB - American Chemical Society (ACS)
SP - 4275-4280
IS - 21
VL - 42
PMID - 10543871
SN - 0022-2623
SN - 1520-4804
ER -
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BibTex (до 50 авторов)
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@article{1999_Posner,
author = {Gary H. Posner and Poonsakdi Ploypradith and Michael H Parker and Hardwin Odowd and Soon-Hyung Woo and John Northrop and Mikhail Krasavin and Patrick T Dolan and Thomas W. Kensler and Suji Xie and Theresa A Shapiro},
title = {Antimalarial, antiproliferative, and antitumor activities of artemisinin-derived, chemically robust, trioxane dimers.},
journal = {Journal of Medicinal Chemistry},
year = {1999},
volume = {42},
publisher = {American Chemical Society (ACS)},
month = {sep},
url = {https://pubs.acs.org/doi/10.1021/jm990363d},
number = {21},
pages = {4275--4280},
doi = {10.1021/jm990363d}
}
Цитировать
MLA
Скопировать
Posner, Gary H., et al. “Antimalarial, antiproliferative, and antitumor activities of artemisinin-derived, chemically robust, trioxane dimers..” Journal of Medicinal Chemistry, vol. 42, no. 21, Sep. 1999, pp. 4275-4280. https://pubs.acs.org/doi/10.1021/jm990363d.