Synthesis of a protected peptide corresponding to residues 1-25 of the .beta.-amyloid protein of Alzheimer's disease

The deposition of proteinaceous amyloid plaque in the brain is a characteristic of Alzheimer's disease. These plaques are composed of the 42 amino acid β-amyloid protein (βA4), the sequence of which has been determined. This paper reports the synthesis, by solid-phase fragment coupling, of a 25-residue protected peptide corresponding to residues 1-25 of βA4. This peptide was prepared from four protected fragments which were coupled sequentially on the Kaiser oxime resin.