, volume 71 , issue 18 , pages 7075-7078

Concise Synthesis of Enantiopure α-Trifluoromethyl Alanines, Diamines, and Amino Alcohols via the Strecker-type Reaction

Florent Huguenot ¹

T Brigaud ¹

Hide authors affiliations Show authors affiliations: 1 affiliation

Laboratoire “Réactions Sélectives et Applications”, UMR CNRS 6519, Université de Reims-Champagne-Ardenne, Faculté des Sciences, BP 1039, 51687 Reims Cedex 2, France, and Laboratoire “Synthèse Organique Sélective et Chimie Organométallique” (SOSCO), UMR CNRS 8123, Université de Cergy-Pontoise-5, Mail Gay-Lussac-Neuville sur Oise, 95031 Cergy-Pontoise Cedex, France thierry.brigaud@u-cergy.fr

CY Cergy Paris University

University of Reims Champagne-Ardenne

Publication type: Journal Article

Publication date: 2006-08-11

American Chemical Society (ACS)

Journal of Organic Chemistry

scimago Q2

wos Q1

SJR: 0.737

CiteScore: 6.1

Impact factor: 3.6

ISSN: 00223263, 15206904

DOI: 10.1021/jo0607717

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PubMed ID: 16930068

Organic Chemistry

Abstract

Diastereomerically pure alpha-trifluoromethyl alpha-amino nitriles obtained by Strecker-type reactions from chiral CF3 imines and iminium proved to be very attractive versatile intermediates for the synthesis of various alpha-trifluoromethyl amino compounds. From these synthons, both enantiomers of alpha-trifluoromethyl alanine, trifluoromethyl 1,2-diamines, and amino alcohols were conveniently obtained in enantiopure form in high yields in a few steps.

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Huguenot F., Brigaud T. Concise Synthesis of Enantiopure α-Trifluoromethyl Alanines, Diamines, and Amino Alcohols via the Strecker-type Reaction // Journal of Organic Chemistry. 2006. Vol. 71. No. 18. pp. 7075-7078.

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RIS |

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RIS Copy

TY - JOUR

DO - 10.1021/jo0607717

UR - https://doi.org/10.1021/jo0607717

TI - Concise Synthesis of Enantiopure α-Trifluoromethyl Alanines, Diamines, and Amino Alcohols via the Strecker-type Reaction

T2 - Journal of Organic Chemistry

AU - Huguenot, Florent

AU - Brigaud, T

PY - 2006

DA - 2006/08/11

PB - American Chemical Society (ACS)

SP - 7075-7078

IS - 18

VL - 71

PMID - 16930068

SN - 0022-3263

SN - 1520-6904

ER -

BibTex |

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BibTex (up to 50 authors) Copy

@article{2006_Huguenot,

author = {Florent Huguenot and T Brigaud},

title = {Concise Synthesis of Enantiopure α-Trifluoromethyl Alanines, Diamines, and Amino Alcohols via the Strecker-type Reaction},

journal = {Journal of Organic Chemistry},

year = {2006},

volume = {71},

publisher = {American Chemical Society (ACS)},

month = {aug},

url = {https://doi.org/10.1021/jo0607717},

number = {18},

pages = {7075--7078},

doi = {10.1021/jo0607717}

}

MLA

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MLA Copy

Huguenot, Florent, and T Brigaud. “Concise Synthesis of Enantiopure α-Trifluoromethyl Alanines, Diamines, and Amino Alcohols via the Strecker-type Reaction.” Journal of Organic Chemistry, vol. 71, no. 18, Aug. 2006, pp. 7075-7078. https://doi.org/10.1021/jo0607717.

Publisher

American Chemical Society (ACS)

Journal

Journal of Organic Chemistry

scimago Q2

wos Q1

SJR

0.737

CiteScore

6.1

Impact factor

3.6

ISSN

00223263 (Print)

15206904 (Electronic)