, volume 76 , issue 11 , pages 4600-4605

Copper-Catalyzed Cascade Synthesis of Alkyl 6-Aminobenzimidazo[2,1-a]isoquinoline-5-carboxylates

Juyou Lu ¹

Hua Fu ¹

Hide authors affiliations Show authors affiliations: 1 affiliation

Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology (Ministry of Education), Department of Chemistry, Tsinghua University, Beijing 100084, P. R. China |

Publication type: Journal Article

Publication date: 2011-05-04

American Chemical Society (ACS)

Journal of Organic Chemistry

scimago Q2

wos Q1

SJR: 0.737

CiteScore: 6.1

Impact factor: 3.6

ISSN: 00223263, 15206904

DOI: 10.1021/jo200508q

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PubMed ID: 21520964

Organic Chemistry

Abstract

A convenient and efficient copper-catalyzed cascade method has been developed for synthesis of benzimidazoisoquinoline derivatives via reactions of readily available substituted 2-(2-halophenyl)benzoimidazoles with alkyl cyanoacetates under mild condition, and the corresponding alkyl 6-aminobenzimidazo[2,1-a]isoquinoline-5-carboxylates were obtained in good to excellent yields. The novel method provides diverse and useful poly N-heterocyclic compounds for combinatorial chemistry and medicinal chemistry.

Found

1 citation

Loginov Dmitry

🥼

DSc in Chemistry

126 publications, 1 794 citations, 36 reviews

h-index: 25

A.N.Nesmeyanov Institute of Organoelement Compounds of the Russian Academy of Sciences

Research interests

Catalysis

Coordination Chemistry

Organic Chemistry

Organic synthesis

Organometallic Chemistry

Photonics

1 citation

Arsenov Mikhail

13 publications, 125 citations

h-index: 7

A.N.Nesmeyanov Institute of Organoelement Compounds of the Russian Academy of Sciences

Research interests

Asymmetric metal complex catalysis

Catalysis

Organic Chemistry

Organoelement chemistry

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Lu J., Fu H. Copper-Catalyzed Cascade Synthesis of Alkyl 6-Aminobenzimidazo[2,1-a]isoquinoline-5-carboxylates // Journal of Organic Chemistry. 2011. Vol. 76. No. 11. pp. 4600-4605.

GOST all authors (up to 50) Copy

Lu J., Fu H. Copper-Catalyzed Cascade Synthesis of Alkyl 6-Aminobenzimidazo[2,1-a]isoquinoline-5-carboxylates // Journal of Organic Chemistry. 2011. Vol. 76. No. 11. pp. 4600-4605.

RIS |

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RIS Copy

TY - JOUR

DO - 10.1021/jo200508q

UR - https://doi.org/10.1021/jo200508q

TI - Copper-Catalyzed Cascade Synthesis of Alkyl 6-Aminobenzimidazo[2,1-a]isoquinoline-5-carboxylates

T2 - Journal of Organic Chemistry

AU - Lu, Juyou

AU - Fu, Hua

PY - 2011

DA - 2011/05/04

PB - American Chemical Society (ACS)

SP - 4600-4605

IS - 11

VL - 76

PMID - 21520964

SN - 0022-3263

SN - 1520-6904

ER -

BibTex |

Cite this

BibTex (up to 50 authors) Copy

@article{2011_Lu,

author = {Juyou Lu and Hua Fu},

title = {Copper-Catalyzed Cascade Synthesis of Alkyl 6-Aminobenzimidazo[2,1-a]isoquinoline-5-carboxylates},

journal = {Journal of Organic Chemistry},

year = {2011},

volume = {76},

publisher = {American Chemical Society (ACS)},

month = {may},

url = {https://doi.org/10.1021/jo200508q},

number = {11},

pages = {4600--4605},

doi = {10.1021/jo200508q}

}

MLA

Cite this

MLA Copy

Lu, Juyou, and Hua Fu. “Copper-Catalyzed Cascade Synthesis of Alkyl 6-Aminobenzimidazo[2,1-a]isoquinoline-5-carboxylates.” Journal of Organic Chemistry, vol. 76, no. 11, May. 2011, pp. 4600-4605. https://doi.org/10.1021/jo200508q.

Publisher

American Chemical Society (ACS)

Journal

Journal of Organic Chemistry

scimago Q2

wos Q1

SJR

0.737

CiteScore

6.1

Impact factor

3.6

ISSN

00223263 (Print)

15206904 (Electronic)