Synthesis of 2-Alkyl-Substituted Chromone Derivatives Using Microwave Irradiation
Publication type: Journal Article
Publication date: 2009-03-11
scimago Q2
wos Q1
SJR: 0.737
CiteScore: 6.1
Impact factor: 3.6
ISSN: 00223263, 15206904
PubMed ID:
19323574
Organic Chemistry
Abstract
A base-promoted condensation between 2-hydroxyacetophenones and aliphatic aldehydes has been studied. The reaction has been optimized to afford 2-alkyl-substituted 4-chromanones in an efficient manner using microwave heating. Performing the reaction using diisopropylamine in EtOH at 170 degrees C for 1 h gave moderate to high yields (43-88%). The 4-chromanones could be further converted into highly functionalized 2,3,6,8-tetrasubstituted chromones in which a 3-substituent (acetate, amine, or bromine) was introduced via straightforward chemical transformations.
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64
Total citations:
64
Citations from 2025:
3
(4.69%)
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GOST
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Fridén Saxin M. et al. Synthesis of 2-Alkyl-Substituted Chromone Derivatives Using Microwave Irradiation // Journal of Organic Chemistry. 2009. Vol. 74. No. 7. pp. 2755-2759.
GOST all authors (up to 50)
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Fridén Saxin M., Pemberton N., Da Silva Andersson K., Dyrager C., Friberg A., Grøtli M., Luthman K. Synthesis of 2-Alkyl-Substituted Chromone Derivatives Using Microwave Irradiation // Journal of Organic Chemistry. 2009. Vol. 74. No. 7. pp. 2755-2759.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1021/jo802783z
UR - https://doi.org/10.1021/jo802783z
TI - Synthesis of 2-Alkyl-Substituted Chromone Derivatives Using Microwave Irradiation
T2 - Journal of Organic Chemistry
AU - Fridén Saxin, Maria
AU - Pemberton, Nils
AU - Da Silva Andersson, Krystle
AU - Dyrager, Christine
AU - Friberg, Annika
AU - Grøtli, Morten
AU - Luthman, Kristina
PY - 2009
DA - 2009/03/11
PB - American Chemical Society (ACS)
SP - 2755-2759
IS - 7
VL - 74
PMID - 19323574
SN - 0022-3263
SN - 1520-6904
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2009_Fridén Saxin,
author = {Maria Fridén Saxin and Nils Pemberton and Krystle Da Silva Andersson and Christine Dyrager and Annika Friberg and Morten Grøtli and Kristina Luthman},
title = {Synthesis of 2-Alkyl-Substituted Chromone Derivatives Using Microwave Irradiation},
journal = {Journal of Organic Chemistry},
year = {2009},
volume = {74},
publisher = {American Chemical Society (ACS)},
month = {mar},
url = {https://doi.org/10.1021/jo802783z},
number = {7},
pages = {2755--2759},
doi = {10.1021/jo802783z}
}
Cite this
MLA
Copy
Fridén Saxin, Maria, et al. “Synthesis of 2-Alkyl-Substituted Chromone Derivatives Using Microwave Irradiation.” Journal of Organic Chemistry, vol. 74, no. 7, Mar. 2009, pp. 2755-2759. https://doi.org/10.1021/jo802783z.