Physicochemical Evaluation of Nanoparticles Assembled from Poly(lactic acid)−Poly(ethylene glycol) (PLA−PEG) Block Copolymers as Drug Delivery Vehicles
Publication type: Journal Article
Publication date: 2001-05-01
scimago Q1
wos Q2
SJR: 0.763
CiteScore: 6.0
Impact factor: 3.9
ISSN: 07437463, 15205827
Spectroscopy
Electrochemistry
Condensed Matter Physics
General Materials Science
Surfaces and Interfaces
Abstract
Nanoparticles assembled from poly(d,l-lactic acid)−poly(ethylene glycol) (PLA−PEG) block copolymers may have a therapeutic application in site-specific drug delivery. A series of AB block copolymers based on a fixed PEG block (5 kDa) and a varying PLA segment (2−110 kDa) have been synthesized by the ring-opening polymerization of d,l-lactide using stannous octoate as a catalyst. These copolymers assembled to form spherical nanoparticles in aqueous media following precipitation from a water-miscible organic solvent. 1H NMR studies of the PLA−PEG nanoparticles in D2O confirmed their core−shell structure, with negligible penetration of the hydrated PEG chains into the PLA core. The influence of the PLA block molecular weight on the hydrodynamic size and micellar aggregation number of the assemblies was determined by dynamic and static light scattering techniques. The hydrodynamic radius of the PLA−PEG 2:5−30:5 nanoparticles was solely dependent on the copolymer architecture and scaled linearly as NPLA1/3, wh...
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Total citations:
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Citations from 2025:
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(1.89%)
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GOST
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Riley T. et al. Physicochemical Evaluation of Nanoparticles Assembled from Poly(lactic acid)−Poly(ethylene glycol) (PLA−PEG) Block Copolymers as Drug Delivery Vehicles // Langmuir. 2001. Vol. 17. No. 11. pp. 3168-3174.
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Riley T., Stolnik S., Heald C., Xiong C. D., Garnett M., Illum L., Davis S. S., Purkiss S. C., BARLOW R. J., Gellert P. Physicochemical Evaluation of Nanoparticles Assembled from Poly(lactic acid)−Poly(ethylene glycol) (PLA−PEG) Block Copolymers as Drug Delivery Vehicles // Langmuir. 2001. Vol. 17. No. 11. pp. 3168-3174.
Cite this
RIS
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TY - JOUR
DO - 10.1021/la001226i
UR - https://doi.org/10.1021/la001226i
TI - Physicochemical Evaluation of Nanoparticles Assembled from Poly(lactic acid)−Poly(ethylene glycol) (PLA−PEG) Block Copolymers as Drug Delivery Vehicles
T2 - Langmuir
AU - Riley, T.
AU - Stolnik, S.
AU - Heald, C.R
AU - Xiong, C D
AU - Garnett, M.
AU - Illum, L.
AU - Davis, S. S.
AU - Purkiss, S C
AU - BARLOW, R. J.
AU - Gellert, Paul
PY - 2001
DA - 2001/05/01
PB - American Chemical Society (ACS)
SP - 3168-3174
IS - 11
VL - 17
SN - 0743-7463
SN - 1520-5827
ER -
Cite this
BibTex (up to 50 authors)
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@article{2001_Riley,
author = {T. Riley and S. Stolnik and C.R Heald and C D Xiong and M. Garnett and L. Illum and S. S. Davis and S C Purkiss and R. J. BARLOW and Paul Gellert},
title = {Physicochemical Evaluation of Nanoparticles Assembled from Poly(lactic acid)−Poly(ethylene glycol) (PLA−PEG) Block Copolymers as Drug Delivery Vehicles},
journal = {Langmuir},
year = {2001},
volume = {17},
publisher = {American Chemical Society (ACS)},
month = {may},
url = {https://doi.org/10.1021/la001226i},
number = {11},
pages = {3168--3174},
doi = {10.1021/la001226i}
}
Cite this
MLA
Copy
Riley, T., et al. “Physicochemical Evaluation of Nanoparticles Assembled from Poly(lactic acid)−Poly(ethylene glycol) (PLA−PEG) Block Copolymers as Drug Delivery Vehicles.” Langmuir, vol. 17, no. 11, May. 2001, pp. 3168-3174. https://doi.org/10.1021/la001226i.