Thiolated Mucoadhesive and PEGylated Nonmucoadhesive Organosilica Nanoparticles from 3-Mercaptopropyltrimethoxysilane
Publication type: Journal Article
Publication date: 2011-08-02
scimago Q1
wos Q2
SJR: 0.763
CiteScore: 6.0
Impact factor: 3.9
ISSN: 07437463, 15205827
PubMed ID:
21707076
Spectroscopy
Electrochemistry
Condensed Matter Physics
General Materials Science
Surfaces and Interfaces
Abstract
A novel approach has been developed to synthesize thiolated sub-100 nm organosilica nanoparticles from 3-mercaptopropyltrimethoxysilane (MPTS) through its self-condensation in dimethylsulfoxide in contact with atmospheric oxygen. The formation of MPTS nanoparticles proceeds through the condensation of methoxysilane groups and simultaneous disulfide bridging caused by partial oxidation of thiol groups. These nanoparticles showed excellent colloidal stability in dilute aqueous dispersions but underwent further self-assembly into chains and necklaces at higher concentrations. They exhibited very good ability to adhere to ocular mucosal surfaces, which can find applications in drug delivery. The thiolated nanoparticles could also be easily modified through PEGylation resulting in a loss of their mucoadhesive properties.
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Total citations:
87
Citations from 2025:
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(3.45%)
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GOST
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Irmukhametova G. S. Thiolated Mucoadhesive and PEGylated Nonmucoadhesive Organosilica Nanoparticles from 3-Mercaptopropyltrimethoxysilane // Langmuir. 2011. Vol. 27. No. 15. pp. 9551-9556.
GOST all authors (up to 50)
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Irmukhametova G. S. Thiolated Mucoadhesive and PEGylated Nonmucoadhesive Organosilica Nanoparticles from 3-Mercaptopropyltrimethoxysilane // Langmuir. 2011. Vol. 27. No. 15. pp. 9551-9556.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1021/la201385h
UR - https://doi.org/10.1021/la201385h
TI - Thiolated Mucoadhesive and PEGylated Nonmucoadhesive Organosilica Nanoparticles from 3-Mercaptopropyltrimethoxysilane
T2 - Langmuir
AU - Irmukhametova, Galiya S
PY - 2011
DA - 2011/08/02
PB - American Chemical Society (ACS)
SP - 9551-9556
IS - 15
VL - 27
PMID - 21707076
SN - 0743-7463
SN - 1520-5827
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2011_Irmukhametova,
author = {Galiya S Irmukhametova},
title = {Thiolated Mucoadhesive and PEGylated Nonmucoadhesive Organosilica Nanoparticles from 3-Mercaptopropyltrimethoxysilane},
journal = {Langmuir},
year = {2011},
volume = {27},
publisher = {American Chemical Society (ACS)},
month = {aug},
url = {https://doi.org/10.1021/la201385h},
number = {15},
pages = {9551--9556},
doi = {10.1021/la201385h}
}
Cite this
MLA
Copy
Irmukhametova, Galiya S., et al. “Thiolated Mucoadhesive and PEGylated Nonmucoadhesive Organosilica Nanoparticles from 3-Mercaptopropyltrimethoxysilane.” Langmuir, vol. 27, no. 15, Aug. 2011, pp. 9551-9556. https://doi.org/10.1021/la201385h.