Synthesis and Characterization of pH- and Temperature-Sensitive Poly(methacrylic acid)/Poly(N-isopropylacrylamide) Interpenetrating Polymeric Networks
Jing Zhang
1
,
Nicholas A. Peppas
1
Publication type: Journal Article
Publication date: 1999-12-11
scimago Q1
wos Q1
SJR: 1.352
CiteScore: 9.0
Impact factor: 5.2
ISSN: 00249297, 15205835
Materials Chemistry
Organic Chemistry
Inorganic Chemistry
Polymers and Plastics
Abstract
Hydrogels of an interpenetrating polymeric network (IPN) composed of the temperature-sensitive poly(N-isopropylacrylamide) (PNIPAAm) and the pH-sensitive poly(methacrylic acid) (PMAA) were prepared by a sequential UV polymerization method. The IPN hydrogels were characterized for their temperature- and pH-responsive behavior by equilibrium swelling studies, oscillatory swelling studies, and differential scanning calorimetry. The permeability of these IPNs has been investigated under various pH and temperature conditions. The results showed that these hydrogels exhibited a combined pH- and temperature-sensitivity at a temperature range of 31−32 °C and a pH value of approximately 5.5. Permeation study results indicate a significant size exclusion behavior while model drugs with different sizes permeate through the IPN membranes. The permeability of the IPN membrane can be significantly affected by varying the pH and temperature conditions.
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455
Total citations:
455
Citations from 2024:
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(2.86%)
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GOST
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Zhang J., Peppas N. A. Synthesis and Characterization of pH- and Temperature-Sensitive Poly(methacrylic acid)/Poly(N-isopropylacrylamide) Interpenetrating Polymeric Networks // Macromolecules. 1999. Vol. 33. No. 1. pp. 102-107.
GOST all authors (up to 50)
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Zhang J., Peppas N. A. Synthesis and Characterization of pH- and Temperature-Sensitive Poly(methacrylic acid)/Poly(N-isopropylacrylamide) Interpenetrating Polymeric Networks // Macromolecules. 1999. Vol. 33. No. 1. pp. 102-107.
Cite this
RIS
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TY - JOUR
DO - 10.1021/ma991398q
UR - https://doi.org/10.1021/ma991398q
TI - Synthesis and Characterization of pH- and Temperature-Sensitive Poly(methacrylic acid)/Poly(N-isopropylacrylamide) Interpenetrating Polymeric Networks
T2 - Macromolecules
AU - Zhang, Jing
AU - Peppas, Nicholas A.
PY - 1999
DA - 1999/12/11
PB - American Chemical Society (ACS)
SP - 102-107
IS - 1
VL - 33
SN - 0024-9297
SN - 1520-5835
ER -
Cite this
BibTex (up to 50 authors)
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@article{1999_Zhang,
author = {Jing Zhang and Nicholas A. Peppas},
title = {Synthesis and Characterization of pH- and Temperature-Sensitive Poly(methacrylic acid)/Poly(N-isopropylacrylamide) Interpenetrating Polymeric Networks},
journal = {Macromolecules},
year = {1999},
volume = {33},
publisher = {American Chemical Society (ACS)},
month = {dec},
url = {https://doi.org/10.1021/ma991398q},
number = {1},
pages = {102--107},
doi = {10.1021/ma991398q}
}
Cite this
MLA
Copy
Zhang, Jing, and Nicholas A. Peppas. “Synthesis and Characterization of pH- and Temperature-Sensitive Poly(methacrylic acid)/Poly(N-isopropylacrylamide) Interpenetrating Polymeric Networks.” Macromolecules, vol. 33, no. 1, Dec. 1999, pp. 102-107. https://doi.org/10.1021/ma991398q.