Enhanced siRNA Delivery Using a Combination of an Arginine-Grafted Bioreducible Polymer, Ultrasound, and Microbubbles in Cancer Cells
Тип публикации: Journal Article
Дата публикации: 2013-04-05
scimago Q1
wos Q1
БС1
SJR: 0.968
CiteScore: 7.8
Impact factor: 4.5
ISSN: 15438384, 15438392
PubMed ID:
23527953
Drug Discovery
Pharmaceutical Science
Molecular Medicine
Краткое описание
RNAi-based gene therapy for cancer treatment has not shown significant clinical impact due to poor siRNA delivery to the target site. Here, we design a nonviral siRNA gene carrier using a combination of an arginine-grafted bioreducible polymer (ABP), microbubbles (MB), and ultrasound (US), for targeting vascular endothelial growth factor (VEGF) in a human ovarian cancer cell line. Newly designed MBs with a perfluorocrownether gas core show higher stability compared to controls. Further, MBs in combination with polyplexes show a significant higher loading capacity compared to naked siRNA. Lastly, only siRNA-ABP-MB (SAM) complexes in combination with US show significant VEGF knock down in A2780 human ovarian cancer cell line compared to naked siRNA when incubated for a short time after sonication treatment.
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21
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(4.76%)
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ГОСТ
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Florinas S., Nam H. Y., Kim S. J. Enhanced siRNA Delivery Using a Combination of an Arginine-Grafted Bioreducible Polymer, Ultrasound, and Microbubbles in Cancer Cells // Molecular Pharmaceutics. 2013. Vol. 10. No. 5. pp. 2021-2030.
ГОСТ со всеми авторами (до 50)
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Florinas S., Nam H. Y., Kim S. J. Enhanced siRNA Delivery Using a Combination of an Arginine-Grafted Bioreducible Polymer, Ultrasound, and Microbubbles in Cancer Cells // Molecular Pharmaceutics. 2013. Vol. 10. No. 5. pp. 2021-2030.
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RIS
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TY - JOUR
DO - 10.1021/mp400048p
UR - https://doi.org/10.1021/mp400048p
TI - Enhanced siRNA Delivery Using a Combination of an Arginine-Grafted Bioreducible Polymer, Ultrasound, and Microbubbles in Cancer Cells
T2 - Molecular Pharmaceutics
AU - Florinas, Stelios
AU - Nam, Hye Yeong
AU - Kim, Su Jin
PY - 2013
DA - 2013/04/05
PB - American Chemical Society (ACS)
SP - 2021-2030
IS - 5
VL - 10
PMID - 23527953
SN - 1543-8384
SN - 1543-8392
ER -
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BibTex (до 50 авторов)
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@article{2013_Florinas,
author = {Stelios Florinas and Hye Yeong Nam and Su Jin Kim},
title = {Enhanced siRNA Delivery Using a Combination of an Arginine-Grafted Bioreducible Polymer, Ultrasound, and Microbubbles in Cancer Cells},
journal = {Molecular Pharmaceutics},
year = {2013},
volume = {10},
publisher = {American Chemical Society (ACS)},
month = {apr},
url = {https://doi.org/10.1021/mp400048p},
number = {5},
pages = {2021--2030},
doi = {10.1021/mp400048p}
}
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MLA
Скопировать
Florinas, Stelios, et al. “Enhanced siRNA Delivery Using a Combination of an Arginine-Grafted Bioreducible Polymer, Ultrasound, and Microbubbles in Cancer Cells.” Molecular Pharmaceutics, vol. 10, no. 5, Apr. 2013, pp. 2021-2030. https://doi.org/10.1021/mp400048p.