Pharmaceutical cocrystals of diflunisal and diclofenac with theophylline
Artem O Surov
1
,
Alexander P. Voronin
1
,
Alex N Manin
1
,
Nikolay G Manin
1
,
German Perlovich
1
,
GERMAN L. PERLOVICH
1
Publication type: Journal Article
Publication date: 2014-09-11
scimago Q1
wos Q1
SJR: 0.968
CiteScore: 7.8
Impact factor: 4.5
ISSN: 15438384, 15438392
PubMed ID:
25184906
Drug Discovery
Pharmaceutical Science
Molecular Medicine
Abstract
Pharmaceutical cocrystals of nonsteroidal anti-inflammatory drugs diflunisal (DIF) and diclofenac (DIC) with theophylline (THP) were obtained, and their crystal structures were determined. In both of the crystal structures, molecules form a hydrogen bonded supramolecular unit consisting of a centrosymmetric dimer of THP and two molecules of active pharmaceutical ingredient (API). Crystal lattice energy calculations showed that the packing energy gain of the [DIC + THP] cocrystal is derived mainly from the dispersion energy, which dominates the structures of the cocrystals. The enthalpies of cocrystal formation were estimated by solution calorimetry, and their thermal stability was studied by differential scanning calorimetry. The cocrystals showed an enhancement of apparent solubility compared to the corresponding pure APIs, while the intrinsic dissolution rates are comparable. Both cocrystals demonstrated physical stability upon storing at different relative humidity.
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GOST
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Surov A. O. et al. Pharmaceutical cocrystals of diflunisal and diclofenac with theophylline // Molecular Pharmaceutics. 2014. Vol. 11. No. 10. pp. 3707-3715.
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Surov A. O., Voronin A., Voronin A. P., Manin A. N., Manin N. G., Kuz'mina L. G., Churakov A. V., Perlovich G., PERLOVICH G. L. Pharmaceutical cocrystals of diflunisal and diclofenac with theophylline // Molecular Pharmaceutics. 2014. Vol. 11. No. 10. pp. 3707-3715.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1021/mp5004652
UR - https://pubs.acs.org/doi/10.1021/mp5004652
TI - Pharmaceutical cocrystals of diflunisal and diclofenac with theophylline
T2 - Molecular Pharmaceutics
AU - Surov, Artem O
AU - Voronin, Alexander
AU - Voronin, Alexander P.
AU - Manin, Alex N
AU - Manin, Nikolay G
AU - Kuz'mina, Lyudmila G.
AU - Churakov, Andrei V.
AU - Perlovich, German
AU - PERLOVICH, GERMAN L.
PY - 2014
DA - 2014/09/11
PB - American Chemical Society (ACS)
SP - 3707-3715
IS - 10
VL - 11
PMID - 25184906
SN - 1543-8384
SN - 1543-8392
ER -
Cite this
BibTex (up to 50 authors)
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@article{2014_Surov,
author = {Artem O Surov and Alexander Voronin and Alexander P. Voronin and Alex N Manin and Nikolay G Manin and Lyudmila G. Kuz'mina and Andrei V. Churakov and German Perlovich and GERMAN L. PERLOVICH},
title = {Pharmaceutical cocrystals of diflunisal and diclofenac with theophylline},
journal = {Molecular Pharmaceutics},
year = {2014},
volume = {11},
publisher = {American Chemical Society (ACS)},
month = {sep},
url = {https://pubs.acs.org/doi/10.1021/mp5004652},
number = {10},
pages = {3707--3715},
doi = {10.1021/mp5004652}
}
Cite this
MLA
Copy
Surov, Artem O., et al. “Pharmaceutical cocrystals of diflunisal and diclofenac with theophylline.” Molecular Pharmaceutics, vol. 11, no. 10, Sep. 2014, pp. 3707-3715. https://pubs.acs.org/doi/10.1021/mp5004652.