Molecular Pharmaceutics, volume 12, issue 3, pages 997-1003

Release Kinetics Study of Poorly Water-Soluble Drugs from Nanoparticles: Are We Doing It Right?

Abouelmagd Sara A. ¹

Sun Bo ¹

Chang Alice C ¹

Ku Youn Jin ¹

Yeo Yoon ¹

Hide authors affiliations Show authors affiliations: 1 affiliation

Department of Industrial and Physical Pharmacy and ‡Weldon School of Biomedical Engineering, Purdue University, West Lafayette, Indiana 47907, United States |

Publication type: Journal Article

Publication date: 2015-02-17

American Chemical Society (ACS)

Journal: Molecular Pharmaceutics

Quartile SCImago

Quartile WOS

Impact factor: 4.9

ISSN: 15438384, 15438392

DOI: 10.1021/mp500817h

Copy DOI

PubMed ID: 25658769

Drug Discovery

Pharmaceutical Science

Molecular Medicine

Abstract

In vitro drug release kinetics studies are routinely performed to examine the ability of new drug formulations to modulate drug release. The underlying assumption is that the studies are performed in a sufficiently dilute solution, where the drug release is not limited by the solubility and the difference in release kinetics profile reflects the performance of a drug carrier in vivo. This condition is, however, difficult to meet with poorly water-soluble drug formulations, as it requires a very large volume of release medium relative to the formulation mass, which makes it challenging to measure the drug concentration accurately. These difficulties are aggravated with nanoparticle (NP) formulations, which are hard to separate from the release medium and thus require a dialysis bag or repeated high-speed centrifugation for sampling. Perhaps for these reasons, drug release kinetics studies of NPs of poorly water-soluble drugs are often performed in suboptimal conditions in which the NPs are not sufficiently diluted. However, such a practice can potentially underestimate drug release from NPs, leading to an inaccurate prediction that the NPs will attenuate the drug activity in vivo. Here we perform release kinetics studies of two different NP formulations of paclitaxel, a representative poorly water-soluble drug, according to common practices in the literature. We find that the drug release from NPs can be substantially underestimated depending on the choice of the release medium, NP/medium ratio, and handling of release samples. We discuss potential consequences of underestimating drug release, ending with suggestions for future studies with NP formulations of poorly water-soluble drugs.

By date By citations

Citations by journals

	2 4 6 8 10 12 14 16
Pharmaceutics	Pharmaceutics, 15, 8.67% Pharmaceutics 15 publications, 8.67%
Journal of Controlled Release	Journal of Controlled Release, 10, 5.78% Journal of Controlled Release 10 publications, 5.78%
International Journal of Pharmaceutics	International Journal of Pharmaceutics, 9, 5.2% International Journal of Pharmaceutics 9 publications, 5.2%
Materials Science and Engineering C	Materials Science and Engineering C, 6, 3.47% Materials Science and Engineering C 6 publications, 3.47%
Molecular Pharmaceutics	Molecular Pharmaceutics, 5, 2.89% Molecular Pharmaceutics 5 publications, 2.89%
International Journal of Molecular Sciences	International Journal of Molecular Sciences, 4, 2.31% International Journal of Molecular Sciences 4 publications, 2.31%
International Journal of Biological Macromolecules	International Journal of Biological Macromolecules, 4, 2.31% International Journal of Biological Macromolecules 4 publications, 2.31%
Journal of Drug Delivery Science and Technology	Journal of Drug Delivery Science and Technology, 4, 2.31% Journal of Drug Delivery Science and Technology 4 publications, 2.31%
Colloids and Surfaces B: Biointerfaces	Colloids and Surfaces B: Biointerfaces, 4, 2.31% Colloids and Surfaces B: Biointerfaces 4 publications, 2.31%
ACS Omega	ACS Omega, 3, 1.73% ACS Omega 3 publications, 1.73%
Nanomaterials	Nanomaterials, 3, 1.73% Nanomaterials 3 publications, 1.73%
Drug Delivery and Translational Research	Drug Delivery and Translational Research, 3, 1.73% Drug Delivery and Translational Research 3 publications, 1.73%
Journal of Nanoparticle Research	Journal of Nanoparticle Research, 3, 1.73% Journal of Nanoparticle Research 3 publications, 1.73%
Nanotechnology	Nanotechnology, 3, 1.73% Nanotechnology 3 publications, 1.73%
Journal of Pharmaceutical Sciences	Journal of Pharmaceutical Sciences, 3, 1.73% Journal of Pharmaceutical Sciences 3 publications, 1.73%
European Polymer Journal	European Polymer Journal, 3, 1.73% European Polymer Journal 3 publications, 1.73%
Advanced healthcare materials	Advanced healthcare materials, 3, 1.73% Advanced healthcare materials 3 publications, 1.73%
Biomaterials Science	Biomaterials Science, 3, 1.73% Biomaterials Science 3 publications, 1.73%
RSC Advances	RSC Advances, 3, 1.73% RSC Advances 3 publications, 1.73%
Nanomedicine	Nanomedicine, 2, 1.16% Nanomedicine 2 publications, 1.16%
Polymers	Polymers, 2, 1.16% Polymers 2 publications, 1.16%
AAPS PharmSciTech	AAPS PharmSciTech, 2, 1.16% AAPS PharmSciTech 2 publications, 1.16%
International Journal of Environmental Science and Technology	International Journal of Environmental Science and Technology, 2, 1.16% International Journal of Environmental Science and Technology 2 publications, 1.16%
Pharmaceutical Research	Pharmaceutical Research, 2, 1.16% Pharmaceutical Research 2 publications, 1.16%
Journal of Colloid and Interface Science	Journal of Colloid and Interface Science, 2, 1.16% Journal of Colloid and Interface Science 2 publications, 1.16%
Carbohydrate Polymers	Carbohydrate Polymers, 2, 1.16% Carbohydrate Polymers 2 publications, 1.16%
Acta Biomaterialia	Acta Biomaterialia, 2, 1.16% Acta Biomaterialia 2 publications, 1.16%
Journal of Pharmaceutical and Biomedical Analysis	Journal of Pharmaceutical and Biomedical Analysis, 2, 1.16% Journal of Pharmaceutical and Biomedical Analysis 2 publications, 1.16%
Colloids and Surfaces A: Physicochemical and Engineering Aspects	Colloids and Surfaces A: Physicochemical and Engineering Aspects, 2, 1.16% Colloids and Surfaces A: Physicochemical and Engineering Aspects 2 publications, 1.16%
Journal of Biomedical Materials Research - Part A	Journal of Biomedical Materials Research - Part A, 2, 1.16% Journal of Biomedical Materials Research - Part A 2 publications, 1.16%
	2 4 6 8 10 12 14 16

Citations by publishers

	10 20 30 40 50 60 70
Elsevier	Elsevier, 66, 38.15% Elsevier 66 publications, 38.15%
Multidisciplinary Digital Publishing Institute (MDPI)	Multidisciplinary Digital Publishing Institute (MDPI), 31, 17.92% Multidisciplinary Digital Publishing Institute (MDPI) 31 publications, 17.92%
Springer Nature	Springer Nature, 19, 10.98% Springer Nature 19 publications, 10.98%
American Chemical Society (ACS)	American Chemical Society (ACS), 16, 9.25% American Chemical Society (ACS) 16 publications, 9.25%
Royal Society of Chemistry (RSC)	Royal Society of Chemistry (RSC), 10, 5.78% Royal Society of Chemistry (RSC) 10 publications, 5.78%
Wiley	Wiley, 7, 4.05% Wiley 7 publications, 4.05%
Taylor & Francis	Taylor & Francis, 7, 4.05% Taylor & Francis 7 publications, 4.05%
IOP Publishing	IOP Publishing, 4, 2.31% IOP Publishing 4 publications, 2.31%
Future Medicine	Future Medicine, 2, 1.16% Future Medicine 2 publications, 1.16%
Center of Pharmaceutical Analytics Ltd	Center of Pharmaceutical Analytics Ltd, 1, 0.58% Center of Pharmaceutical Analytics Ltd 1 publication, 0.58%
Bentham Science	Bentham Science, 1, 0.58% Bentham Science 1 publication, 0.58%
Mary Ann Liebert	Mary Ann Liebert, 1, 0.58% Mary Ann Liebert 1 publication, 0.58%
Pharmaceutical Society of Japan	Pharmaceutical Society of Japan, 1, 0.58% Pharmaceutical Society of Japan 1 publication, 0.58%
The Royal Society	The Royal Society, 1, 0.58% The Royal Society 1 publication, 0.58%
Public Library of Science (PLoS)	Public Library of Science (PLoS), 1, 0.58% Public Library of Science (PLoS) 1 publication, 0.58%
Thieme	Thieme, 1, 0.58% Thieme 1 publication, 0.58%
Hindawi Limited	Hindawi Limited, 1, 0.58% Hindawi Limited 1 publication, 0.58%
American Association for Cancer Research (AACR)	American Association for Cancer Research (AACR), 1, 0.58% American Association for Cancer Research (AACR) 1 publication, 0.58%
	10 20 30 40 50 60 70

We do not take into account publications that without a DOI.
Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
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Abouelmagd S. A. et al. Release Kinetics Study of Poorly Water-Soluble Drugs from Nanoparticles: Are We Doing It Right? // Molecular Pharmaceutics. 2015. Vol. 12. No. 3. pp. 997-1003.

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Abouelmagd S. A., Sun B., Chang A. C., Ku Y. J., Yeo Y. Release Kinetics Study of Poorly Water-Soluble Drugs from Nanoparticles: Are We Doing It Right? // Molecular Pharmaceutics. 2015. Vol. 12. No. 3. pp. 997-1003.

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