ACS Nano, volume 4, issue 9, pages 5487-5497
Quantum Dot Peptide Biosensors for Monitoring Caspase 3 Proteolysis and Calcium Ions
Duane E Prasuhn
1
,
Anne FELTZ
2
,
Juan B Blanco Canosa
3
,
Kimihiro Susumu
4
,
Michael H Stewart
4
,
Bing C Mei
4
,
A V Yakovlev
2
,
Christina Loukou
5
,
Jean-Maurice Mallet
5
,
Martin Oheim
6
,
PHILIP D. DAWSON
3
,
1
Center for Bio/Molecular Science
and Engineering, Code 6900
2
Institut de Biologie, Ecole Normale Supérieure, IBENS, ENS-CNRS UMR 8197, INSERUM U 1024, 46 rue d’Ulm, 75005 Paris, France
|
4
Optical Sciences Division, Code 5611, U.S. Naval Research Laboratory, 4555 Overlook Ave. S.W., Washington, D.C. 20375
5
Départment de Chimie, Ecole Normale Supérieure, ENS-CNRS UMR, 8642, 24 rue Lhomond, Paris, F-75005 France
|
Publication type: Journal Article
Publication date: 2010-09-07
General Physics and Astronomy
General Materials Science
General Engineering
Abstract
The nanoscale size and unique optical properties of semiconductor quantum dots (QDs) have made them attractive as central photoluminescent scaffolds for a variety of biosensing platforms. In this report we functionalize QDs with dye-labeled peptides using two different linkage chemistries to yield Förster resonance energy transfer (FRET)-based sensors capable of monitoring either enzymatic activity or ionic presence. The first sensor targets the proteolytic activity of caspase 3, a key downstream effector of apoptosis. This QD conjugate utilized carbodiimide chemistry to covalently link dye-labeled peptide substrates to the terminal carboxyl groups on the QD's surface hydrophilic ligands in a quantitative manner. Caspase 3 cleaved the peptide substrate and disrupted QD donor-dye acceptor FRET providing signal transduction of enzymatic activity and allowing derivation of relevant Michaelis-Menten kinetic descriptors. The second sensor was designed to monitor Ca2+ ions that are ubiquitous in many biological processes. For this sensor, Cu+-catalyzed [3 + 2] azide-alkyne cycloaddition was exploited to attach a recently developed azide-functionalized CalciumRuby-Cl indicator dye to a cognate alkyne group present on the terminus of a modified peptide. The labeled peptide also expressed a polyhistidine sequence, which facilitated its subsequent metal-affinity coordination to the QD surface establishing the final FRET sensing construct. Adding exogenous Ca2+ to the sensor solution increased the dyes fluorescence, altering the donor-acceptor emission ratio and manifested a dissociation constant similar to that of the native dye. These results highlight the potential for combining peptides with QDs using different chemistries to create sensors for monitoring chemical compounds and biological processes.
Top-30
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2 publications, 1.43%
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2 publications, 1.43%
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2 publications, 1.43%
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1 publication, 0.71%
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Citations by publishers
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American Chemical Society (ACS)
39 publications, 27.86%
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Elsevier
29 publications, 20.71%
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Royal Society of Chemistry (RSC)
22 publications, 15.71%
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Wiley
17 publications, 12.14%
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Springer Nature
9 publications, 6.43%
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Multidisciplinary Digital Publishing Institute (MDPI)
4 publications, 2.86%
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Pleiades Publishing
2 publications, 1.43%
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Future Medicine
1 publication, 0.71%
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World Scientific
1 publication, 0.71%
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The Electrochemical Society
1 publication, 0.71%
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SAGE
1 publication, 0.71%
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Frontiers Media S.A.
1 publication, 0.71%
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Higher Education Press
1 publication, 0.71%
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IOP Publishing
1 publication, 0.71%
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Maad Rayan Publishing Company
1 publication, 0.71%
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Public Library of Science (PLoS)
1 publication, 0.71%
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IEEE
1 publication, 0.71%
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Cambridge University Press
1 publication, 0.71%
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Autonomous Non-profit Organization Editorial Board of the journal Uspekhi Khimii
1 publication, 0.71%
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- We do not take into account publications without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Prasuhn D. E. et al. Quantum Dot Peptide Biosensors for Monitoring Caspase 3 Proteolysis and Calcium Ions // ACS Nano. 2010. Vol. 4. No. 9. pp. 5487-5497.
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Prasuhn D. E., FELTZ A., Blanco Canosa J. B., Susumu K., Stewart M. H., Mei B. C., Yakovlev A. V., Loukou C., Mallet J., Oheim M., DAWSON P. D., Medintz I. L. Quantum Dot Peptide Biosensors for Monitoring Caspase 3 Proteolysis and Calcium Ions // ACS Nano. 2010. Vol. 4. No. 9. pp. 5487-5497.
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TY - JOUR
DO - 10.1021/nn1016132
UR - https://doi.org/10.1021/nn1016132
TI - Quantum Dot Peptide Biosensors for Monitoring Caspase 3 Proteolysis and Calcium Ions
T2 - ACS Nano
AU - Prasuhn, Duane E
AU - FELTZ, Anne
AU - Blanco Canosa, Juan B
AU - Stewart, Michael H
AU - Mei, Bing C
AU - Loukou, Christina
AU - Susumu, Kimihiro
AU - Yakovlev, A V
AU - Mallet, Jean-Maurice
AU - Oheim, Martin
AU - DAWSON, PHILIP D.
AU - Medintz, Igor L
PY - 2010
DA - 2010/09/07 00:00:00
PB - American Chemical Society (ACS)
SP - 5487-5497
IS - 9
VL - 4
SN - 1936-0851
SN - 1936-086X
ER -
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@article{2010_Prasuhn,
author = {Duane E Prasuhn and Anne FELTZ and Juan B Blanco Canosa and Michael H Stewart and Bing C Mei and Christina Loukou and Kimihiro Susumu and A V Yakovlev and Jean-Maurice Mallet and Martin Oheim and PHILIP D. DAWSON and Igor L Medintz},
title = {Quantum Dot Peptide Biosensors for Monitoring Caspase 3 Proteolysis and Calcium Ions},
journal = {ACS Nano},
year = {2010},
volume = {4},
publisher = {American Chemical Society (ACS)},
month = {sep},
url = {https://doi.org/10.1021/nn1016132},
number = {9},
pages = {5487--5497},
doi = {10.1021/nn1016132}
}
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Prasuhn, Duane E., et al. “Quantum Dot Peptide Biosensors for Monitoring Caspase 3 Proteolysis and Calcium Ions.” ACS Nano, vol. 4, no. 9, Sep. 2010, pp. 5487-5497. https://doi.org/10.1021/nn1016132.