ACS Nano, volume 9, issue 1, pages 220-230
Tunable Ultrasmall Visible-to-Extended Near-Infrared Emitting Silver Sulfide Quantum Dots for Integrin-Targeted Cancer Imaging
Publication type: Journal Article
Publication date: 2015-01-07
PubMed ID:
25560768
General Physics and Astronomy
General Materials Science
General Engineering
Abstract
The large size of many near-infrared (NIR) fluorescent nanoparticles prevents rapid extravasation from blood vessels and subsequent diffusion to tumors. This confines in vivo uptake to the peritumoral space and results in high liver retention. In this study, we developed a viscosity modulated approach to synthesize ultrasmall silver sulfide quantum dots (QDs) with distinct tunable light emission from 500 to 1200 nm and a QD core diameter between 1.5 and 9 nm. Conjugation of a tumor-avid cyclic pentapeptide (Arg-Gly-Asp-DPhe-Lys) resulted in monodisperse, water-soluble QDs (hydrodynamic diameter < 10 nm) without loss of the peptide’s high binding affinity to tumor-associated integrins (KI = 1.8 nM/peptide). Fluorescence and electron microscopy showed that selective integrin-mediated internalization was observed only in cancer cells treated with the peptide-labeled QDs, demonstrating that the unlabeled hydrophilic nanoparticles exhibit characteristics of negatively charged fluorescent dye molecules, which typically do not internalize in cells. The biodistribution profiles of intravenously administered QDs in different mouse models of cancer reveal an exceptionally high tumor-to-liver uptake ratio, suggesting that the small sized QDs evaded conventional opsonization and subsequent high uptake in the liver and spleen. The seamless tunability of the QDs over a wide spectral range with only a small increase in size, as well as the ease of labeling the bright and noncytotoxic QDs with biomolecules, provides a platform for multiplexing information, tracking the trafficking of single molecules in cells, and selectively targeting disease biomarkers in living organisms without premature QD opsonization in circulating blood.
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Citations by publishers
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1 publication, 0.55%
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1 publication, 0.55%
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- We do not take into account publications without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Tang R. et al. Tunable Ultrasmall Visible-to-Extended Near-Infrared Emitting Silver Sulfide Quantum Dots for Integrin-Targeted Cancer Imaging // ACS Nano. 2015. Vol. 9. No. 1. pp. 220-230.
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Tang R., Xue J., XU B., Shen D., Sudlow G. P., Achilefu S. Tunable Ultrasmall Visible-to-Extended Near-Infrared Emitting Silver Sulfide Quantum Dots for Integrin-Targeted Cancer Imaging // ACS Nano. 2015. Vol. 9. No. 1. pp. 220-230.
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TY - JOUR
DO - 10.1021/nn5071183
UR - https://doi.org/10.1021/nn5071183
TI - Tunable Ultrasmall Visible-to-Extended Near-Infrared Emitting Silver Sulfide Quantum Dots for Integrin-Targeted Cancer Imaging
T2 - ACS Nano
AU - Xue, Jianpeng
AU - XU, BAOGANG
AU - Shen, Duanwen
AU - Sudlow, Gail P.
AU - Tang, Rui
AU - Achilefu, Samuel
PY - 2015
DA - 2015/01/07 00:00:00
PB - American Chemical Society (ACS)
SP - 220-230
IS - 1
VL - 9
PMID - 25560768
SN - 1936-0851
SN - 1936-086X
ER -
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@article{2015_Tang,
author = {Jianpeng Xue and BAOGANG XU and Duanwen Shen and Gail P. Sudlow and Rui Tang and Samuel Achilefu},
title = {Tunable Ultrasmall Visible-to-Extended Near-Infrared Emitting Silver Sulfide Quantum Dots for Integrin-Targeted Cancer Imaging},
journal = {ACS Nano},
year = {2015},
volume = {9},
publisher = {American Chemical Society (ACS)},
month = {jan},
url = {https://doi.org/10.1021/nn5071183},
number = {1},
pages = {220--230},
doi = {10.1021/nn5071183}
}
Cite this
MLA
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Tang, Rui, et al. “Tunable Ultrasmall Visible-to-Extended Near-Infrared Emitting Silver Sulfide Quantum Dots for Integrin-Targeted Cancer Imaging.” ACS Nano, vol. 9, no. 1, Jan. 2015, pp. 220-230. https://doi.org/10.1021/nn5071183.