Directed Reductive Amination of β-Hydroxy-ketones: Convergent Assembly of the Ritonavir/Lopinavir Core
Тип публикации: Journal Article
Дата публикации: 2006-12-23
SCImago Q1
Tоп 10% SCImago
WOS Q1
БС1
SJR: 1.007
CiteScore: 7.7
Impact factor: 4.7
ISSN: 15237060, 15237052
PubMed ID:
17217281
Organic Chemistry
Biochemistry
Physical and Theoretical Chemistry
Краткое описание
An efficient procedure for the directed reductive amination of beta-hydroxy-ketones (3) for the stereoselective preparation of 1,3-syn-amino alcohols (6) is reported. The operationally simple protocol uses Ti(iOPr)4 for coordination of the intermediate imino alcohol (5) and PMHS as the reducing agent. The method was expanded to an asymmetric aldol reductive amination sequence to allow a highly convergent synthesis of the hydroxy-amine core of the HIV-protease inhibitors ritonavir and lopinavir. [reaction: see text].
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ГОСТ
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Menche D. et al. Directed Reductive Amination of β-Hydroxy-ketones: Convergent Assembly of the Ritonavir/Lopinavir Core // Organic Letters. 2006. Vol. 9. No. 2. pp. 267-270.
ГОСТ со всеми авторами (до 50)
Скопировать
Menche D., Arikan F., Li J., Rudolph S. Directed Reductive Amination of β-Hydroxy-ketones: Convergent Assembly of the Ritonavir/Lopinavir Core // Organic Letters. 2006. Vol. 9. No. 2. pp. 267-270.
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RIS
Скопировать
TY - JOUR
DO - 10.1021/ol062715y
UR - https://doi.org/10.1021/ol062715y
TI - Directed Reductive Amination of β-Hydroxy-ketones: Convergent Assembly of the Ritonavir/Lopinavir Core
T2 - Organic Letters
AU - Menche, Dirk
AU - Arikan, Fatih
AU - Li, Jun
AU - Rudolph, Sven
PY - 2006
DA - 2006/12/23
PB - American Chemical Society (ACS)
SP - 267-270
IS - 2
VL - 9
PMID - 17217281
SN - 1523-7060
SN - 1523-7052
ER -
Цитировать
BibTex (до 50 авторов)
Скопировать
@article{2006_Menche,
author = {Dirk Menche and Fatih Arikan and Jun Li and Sven Rudolph},
title = {Directed Reductive Amination of β-Hydroxy-ketones: Convergent Assembly of the Ritonavir/Lopinavir Core},
journal = {Organic Letters},
year = {2006},
volume = {9},
publisher = {American Chemical Society (ACS)},
month = {dec},
url = {https://doi.org/10.1021/ol062715y},
number = {2},
pages = {267--270},
doi = {10.1021/ol062715y}
}
Цитировать
MLA
Скопировать
Menche, Dirk, et al. “Directed Reductive Amination of β-Hydroxy-ketones: Convergent Assembly of the Ritonavir/Lopinavir Core.” Organic Letters, vol. 9, no. 2, Dec. 2006, pp. 267-270. https://doi.org/10.1021/ol062715y.
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