Ligand-Mediated Highly Effective and Selective C−N Coupling for Synthesizing BioactiveN-Aryltriazole Acyclonucleosides
Publication type: Journal Article
Publication date: 2010-12-17
scimago Q1
wos Q1
SJR: 1.235
CiteScore: 8.7
Impact factor: 5.0
ISSN: 15237060, 15237052
PubMed ID:
21086980
Organic Chemistry
Biochemistry
Physical and Theoretical Chemistry
Abstract
N-aryltriazole nucleosides are new chemical entities with potential biological activity. The two phosphor ligands, Synphos and Xantphos, had a selective and effective impact on Pd-catalyzed C-N coupling with the 5- and 3-bromotriazole acyclonucleoside isomers, affording the corresponding and otherwise difficult to achieve N-aryltriazole nucleosides with good to excellent yields. In addition, two of the synthesized nucleosides showed superior anticancer activity against drug-resistant pancreatic cancer, compared to the reference drug gemcitabine.
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Total citations:
14
Citations from 2025:
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(7.14%)
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GOST
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Fan Y. et al. Ligand-Mediated Highly Effective and Selective C−N Coupling for Synthesizing BioactiveN-Aryltriazole Acyclonucleosides // Organic Letters. 2010. Vol. 12. No. 24. pp. 5712-5715.
GOST all authors (up to 50)
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Fan Y., Xia Y., Peng L. Ligand-Mediated Highly Effective and Selective C−N Coupling for Synthesizing BioactiveN-Aryltriazole Acyclonucleosides // Organic Letters. 2010. Vol. 12. No. 24. pp. 5712-5715.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1021/ol102537p
UR - https://doi.org/10.1021/ol102537p
TI - Ligand-Mediated Highly Effective and Selective C−N Coupling for Synthesizing BioactiveN-Aryltriazole Acyclonucleosides
T2 - Organic Letters
AU - Fan, Yuting
AU - Xia, Yi
AU - Peng, Ling
PY - 2010
DA - 2010/12/17
PB - American Chemical Society (ACS)
SP - 5712-5715
IS - 24
VL - 12
PMID - 21086980
SN - 1523-7060
SN - 1523-7052
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2010_Fan,
author = {Yuting Fan and Yi Xia and Ling Peng},
title = {Ligand-Mediated Highly Effective and Selective C−N Coupling for Synthesizing BioactiveN-Aryltriazole Acyclonucleosides},
journal = {Organic Letters},
year = {2010},
volume = {12},
publisher = {American Chemical Society (ACS)},
month = {dec},
url = {https://doi.org/10.1021/ol102537p},
number = {24},
pages = {5712--5715},
doi = {10.1021/ol102537p}
}
Cite this
MLA
Copy
Fan, Yuting, et al. “Ligand-Mediated Highly Effective and Selective C−N Coupling for Synthesizing BioactiveN-Aryltriazole Acyclonucleosides.” Organic Letters, vol. 12, no. 24, Dec. 2010, pp. 5712-5715. https://doi.org/10.1021/ol102537p.