Organic Letters, volume 15, issue 16, pages 4174-4177

Development of a Practical, Asymmetric Synthesis of the Hepatitis C Virus Protease Inhibitor MK-5172

Jeffrey Kuethe ¹

Yongli Zhong ¹

Nobuyoshi Yasuda ¹

Gregory L Beutner ¹

Katherine Linn ¹

Mary Kim ¹

Benjamin Marcune ¹

Spencer D. Dreher ¹

Guy R Humphrey ¹

Tao Pei ¹

Show full list: 10 authors

Hide authors affiliations Show authors affiliations: 1 affiliation

Process Chemistry, Merck Research Laboratories, P.O. Box 2000, Rahway, New Jersey 07065-0200, United States |

Publication type: Journal Article

Publication date: 2013-08-06

American Chemical Society (ACS)

Journal: Organic Letters

scimago Q1

SJR: 1.245

CiteScore: 9.3

Impact factor: 4.9

ISSN: 15237060, 15237052

DOI: 10.1021/ol401864t

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PubMed ID: 23919347

Organic Chemistry

Biochemistry

Physical and Theoretical Chemistry

Abstract

The development of a practical, asymmetric synthesis of the hepatitis C virus (HCV) protease inhibitor MK-5172 (1), an 18-membered macrocycle, is described.

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CITATIONS

45 Total citations

6 Recent citations

5.75 Field Citation Ratio

0.83 Relative Citation Ratio

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GOST |

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GOST Copy

Kuethe J. et al. Development of a Practical, Asymmetric Synthesis of the Hepatitis C Virus Protease Inhibitor MK-5172 // Organic Letters. 2013. Vol. 15. No. 16. pp. 4174-4177.

GOST all authors (up to 50) Copy

Kuethe J., Zhong Y., Yasuda N., Beutner G. L., Linn K., Kim M., Marcune B., Dreher S. D., Humphrey G. R., Pei T. Development of a Practical, Asymmetric Synthesis of the Hepatitis C Virus Protease Inhibitor MK-5172 // Organic Letters. 2013. Vol. 15. No. 16. pp. 4174-4177.

RIS |

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RIS Copy

TY - JOUR

DO - 10.1021/ol401864t

UR - https://doi.org/10.1021/ol401864t

TI - Development of a Practical, Asymmetric Synthesis of the Hepatitis C Virus Protease Inhibitor MK-5172

T2 - Organic Letters

AU - Kuethe, Jeffrey

AU - Zhong, Yongli

AU - Yasuda, Nobuyoshi

AU - Beutner, Gregory L

AU - Linn, Katherine

AU - Kim, Mary

AU - Marcune, Benjamin

AU - Dreher, Spencer D.

AU - Humphrey, Guy R

AU - Pei, Tao

PY - 2013

DA - 2013/08/06

PB - American Chemical Society (ACS)

SP - 4174-4177

IS - 16

VL - 15

PMID - 23919347

SN - 1523-7060

SN - 1523-7052

ER -

BibTex |

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BibTex (up to 50 authors) Copy

@article{2013_Kuethe,

author = {Jeffrey Kuethe and Yongli Zhong and Nobuyoshi Yasuda and Gregory L Beutner and Katherine Linn and Mary Kim and Benjamin Marcune and Spencer D. Dreher and Guy R Humphrey and Tao Pei},

title = {Development of a Practical, Asymmetric Synthesis of the Hepatitis C Virus Protease Inhibitor MK-5172},

journal = {Organic Letters},

year = {2013},

volume = {15},

publisher = {American Chemical Society (ACS)},

month = {aug},

url = {https://doi.org/10.1021/ol401864t},

number = {16},

pages = {4174--4177},

doi = {10.1021/ol401864t}

}

MLA

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MLA Copy

Kuethe, Jeffrey, et al. “Development of a Practical, Asymmetric Synthesis of the Hepatitis C Virus Protease Inhibitor MK-5172.” Organic Letters, vol. 15, no. 16, Aug. 2013, pp. 4174-4177. https://doi.org/10.1021/ol401864t.

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Publisher

American Chemical Society (ACS)

Journal

Organic Letters

scimago Q1

SJR

1.245

CiteScore

9.3

Impact factor

4.9

ISSN

15237060 (Print)

15237052 (Electronic)