A [2 + 2 + 2]-Cycloaddition Approach toward 6-Oxa-allocolchicinoids with Apoptosis-Inducing Activity
Publication type: Journal Article
Publication date: 2008-12-18
scimago Q1
wos Q1
SJR: 1.235
CiteScore: 8.7
Impact factor: 5.0
ISSN: 15237060, 15237052
PubMed ID:
19093850
Organic Chemistry
Biochemistry
Physical and Theoretical Chemistry
Abstract
Following an A --> ABC strategy, a new synthesis of 6-oxa-allocolchicinoids was developed exploiting a microwave-promoted Co- or Rh-catalyzed intramolecular [2 + 2 + 2]-cycloaddition (alkyne cyclotrimerization) as a key step. The approach opens a short and efficient access to a variety of novel compounds, some of which were found to exhibit significant and selective apoptosis-inducing activities against BJAB tumor cells.
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68
Total citations:
68
Citations from 2024:
2
(2.94%)
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MLA
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GOST
Copy
Nicolaus N. et al. A [2 + 2 + 2]-Cycloaddition Approach toward 6-Oxa-allocolchicinoids with Apoptosis-Inducing Activity // Organic Letters. 2008. Vol. 11. No. 2. pp. 341-344.
GOST all authors (up to 50)
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Nicolaus N., Strauss S., Neudörfl J. M., Prokop A., Schmalz H. A [2 + 2 + 2]-Cycloaddition Approach toward 6-Oxa-allocolchicinoids with Apoptosis-Inducing Activity // Organic Letters. 2008. Vol. 11. No. 2. pp. 341-344.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1021/ol802542c
UR - https://doi.org/10.1021/ol802542c
TI - A [2 + 2 + 2]-Cycloaddition Approach toward 6-Oxa-allocolchicinoids with Apoptosis-Inducing Activity
T2 - Organic Letters
AU - Nicolaus, Norman
AU - Strauss, Susanne
AU - Neudörfl, Jörg M.
AU - Prokop, A.
AU - Schmalz, H.-G.
PY - 2008
DA - 2008/12/18
PB - American Chemical Society (ACS)
SP - 341-344
IS - 2
VL - 11
PMID - 19093850
SN - 1523-7060
SN - 1523-7052
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2008_Nicolaus,
author = {Norman Nicolaus and Susanne Strauss and Jörg M. Neudörfl and A. Prokop and H.-G. Schmalz},
title = {A [2 + 2 + 2]-Cycloaddition Approach toward 6-Oxa-allocolchicinoids with Apoptosis-Inducing Activity},
journal = {Organic Letters},
year = {2008},
volume = {11},
publisher = {American Chemical Society (ACS)},
month = {dec},
url = {https://doi.org/10.1021/ol802542c},
number = {2},
pages = {341--344},
doi = {10.1021/ol802542c}
}
Cite this
MLA
Copy
Nicolaus, Norman, et al. “A [2 + 2 + 2]-Cycloaddition Approach toward 6-Oxa-allocolchicinoids with Apoptosis-Inducing Activity.” Organic Letters, vol. 11, no. 2, Dec. 2008, pp. 341-344. https://doi.org/10.1021/ol802542c.