том 33 издание 11 страницы 2862-2873

A New Family of Doubly Cyclopalladated Diimines. A Remarkable Effect of the Linker between the Metalated Units on Their Cytotoxicity

Тип публикацииJournal Article
Дата публикации2014-05-23
SCImago Q2
WOS Q2
БС1
SJR0.55
CiteScore4.6
Impact factor2.4
ISSN02767333, 15206041
Organic Chemistry
Inorganic Chemistry
Physical and Theoretical Chemistry
Краткое описание
The cyclopalladation of a series of symmetric diimines with the formula (RC6H4CH═NZ)2, where Z = CH2 or (CH2)2OCH2 and R = p-Cl, p-OMe, p-NO2, and o-Cl, is described. Optimal conditions to obtain the dimetalated compounds were found to be palladium(II) acetate, in toluene, at 60 °C and with a reaction time of 2–4 h. The reactivity of the dimetalated compounds with monodentate, bidentate, and bis(monodentate) Lewis bases was also studied. The cytotoxic activity of some selected compounds was evaluated against a panel of adenocarcinoma cell lines (colon HCT116 and breast MCF7 and MDA-MB231). Compounds containing the fragment NCH2CH2OCH2CH2OCH2CH2N exhibited a remarkable cytotoxic activity in the three cancer cells assayed, but complexes containing the NCH2CH2N fragment showed no activity. It seems that the length and flexibility of the central saturated chain in the imine molecule, as well as its lipophilicity and hydrophilicity, explain the different cytotoxicity of the two series of coordination compounds...
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ГОСТ |
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Albert J. et al. A New Family of Doubly Cyclopalladated Diimines. A Remarkable Effect of the Linker between the Metalated Units on Their Cytotoxicity // Organometallics. 2014. Vol. 33. No. 11. pp. 2862-2873.
ГОСТ со всеми авторами (до 50) Скопировать
Albert J., Bosque R., Cadena M., D’Andrea L., Granell J., González A., Quirante J., Calvis C., Messeguer R., Badia J., Baldoma L., Calvet T., Font-Bardia M. A New Family of Doubly Cyclopalladated Diimines. A Remarkable Effect of the Linker between the Metalated Units on Their Cytotoxicity // Organometallics. 2014. Vol. 33. No. 11. pp. 2862-2873.
RIS |
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TY - JOUR
DO - 10.1021/om500382f
UR - https://doi.org/10.1021/om500382f
TI - A New Family of Doubly Cyclopalladated Diimines. A Remarkable Effect of the Linker between the Metalated Units on Their Cytotoxicity
T2 - Organometallics
AU - Albert, Joan
AU - Bosque, Ramón
AU - Cadena, Magali
AU - D’Andrea, Lucía
AU - Granell, Jaume
AU - González, Asensio
AU - Quirante, Josefina
AU - Calvis, Carmen
AU - Messeguer, Ramon
AU - Badia, J.
AU - Baldoma, L.
AU - Calvet, Teresa
AU - Font-Bardia, M.
PY - 2014
DA - 2014/05/23
PB - American Chemical Society (ACS)
SP - 2862-2873
IS - 11
VL - 33
SN - 0276-7333
SN - 1520-6041
ER -
BibTex |
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BibTex (до 50 авторов) Скопировать
@article{2014_Albert,
author = {Joan Albert and Ramón Bosque and Magali Cadena and Lucía D’Andrea and Jaume Granell and Asensio González and Josefina Quirante and Carmen Calvis and Ramon Messeguer and J. Badia and L. Baldoma and Teresa Calvet and M. Font-Bardia},
title = {A New Family of Doubly Cyclopalladated Diimines. A Remarkable Effect of the Linker between the Metalated Units on Their Cytotoxicity},
journal = {Organometallics},
year = {2014},
volume = {33},
publisher = {American Chemical Society (ACS)},
month = {may},
url = {https://doi.org/10.1021/om500382f},
number = {11},
pages = {2862--2873},
doi = {10.1021/om500382f}
}
MLA
Цитировать
Albert, Joan, et al. “A New Family of Doubly Cyclopalladated Diimines. A Remarkable Effect of the Linker between the Metalated Units on Their Cytotoxicity.” Organometallics, vol. 33, no. 11, May. 2014, pp. 2862-2873. https://doi.org/10.1021/om500382f.
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