Improved Process for the Preparation of Montelukast: Development of an Efficient Synthesis, Identification of Critical Impurities and Degradants
1
Zentiva k.s., Department of Chemical Synthesis, U kabelovny 130, Prague 102 01, Czech Republic
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Publication type: Journal Article
Publication date: 2010-02-11
scimago Q1
wos Q1
SJR: 0.865
CiteScore: 5.4
Impact factor: 3.5
ISSN: 10836160, 1520586X
Organic Chemistry
Physical and Theoretical Chemistry
Abstract
An improved and scalable process for the production of montelukast (Singulair, drug for asthma) based on a new and advantageous method of carrying out the key substitution reaction has been developed. The present procedure is distinguished from the previous solutions in the use of linear or cyclic polyethers, which ensures higher selectivity of the key step. The improved process for the preparation of montelukast is able to minimize a content of impurities and allows the effective production of montelukast and its scale-up.
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36
Total citations:
36
Citations from 2024:
3
(8.34%)
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GOST
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Halama A. et al. Improved Process for the Preparation of Montelukast: Development of an Efficient Synthesis, Identification of Critical Impurities and Degradants // Organic Process Research and Development. 2010. Vol. 14. No. 2. pp. 425-431.
GOST all authors (up to 50)
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Halama A., Jirman J., Boušková O., Gibala P., Jarrah K. Improved Process for the Preparation of Montelukast: Development of an Efficient Synthesis, Identification of Critical Impurities and Degradants // Organic Process Research and Development. 2010. Vol. 14. No. 2. pp. 425-431.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1021/op900311z
UR - https://doi.org/10.1021/op900311z
TI - Improved Process for the Preparation of Montelukast: Development of an Efficient Synthesis, Identification of Critical Impurities and Degradants
T2 - Organic Process Research and Development
AU - Halama, Aleš
AU - Jirman, Josef
AU - Boušková, Olga
AU - Gibala, Petr
AU - Jarrah, Kamal
PY - 2010
DA - 2010/02/11
PB - American Chemical Society (ACS)
SP - 425-431
IS - 2
VL - 14
SN - 1083-6160
SN - 1520-586X
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2010_Halama,
author = {Aleš Halama and Josef Jirman and Olga Boušková and Petr Gibala and Kamal Jarrah},
title = {Improved Process for the Preparation of Montelukast: Development of an Efficient Synthesis, Identification of Critical Impurities and Degradants},
journal = {Organic Process Research and Development},
year = {2010},
volume = {14},
publisher = {American Chemical Society (ACS)},
month = {feb},
url = {https://doi.org/10.1021/op900311z},
number = {2},
pages = {425--431},
doi = {10.1021/op900311z}
}
Cite this
MLA
Copy
Halama, Aleš, et al. “Improved Process for the Preparation of Montelukast: Development of an Efficient Synthesis, Identification of Critical Impurities and Degradants.” Organic Process Research and Development, vol. 14, no. 2, Feb. 2010, pp. 425-431. https://doi.org/10.1021/op900311z.