Organic Process Research and Development

, том 14 , издание 2 , страницы 425-431

Improved Process for the Preparation of Montelukast: Development of an Efficient Synthesis, Identification of Critical Impurities and Degradants

Aleš Halama ¹

Josef Jirman ¹

Olga Boušková ¹

Petr Gibala ¹

Kamal Jarrah ¹

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Zentiva k.s., Department of Chemical Synthesis, U kabelovny 130, Prague 102 01, Czech Republic |

Тип публикации: Journal Article

Дата публикации: 2010-02-11

American Chemical Society (ACS)

Organic Process Research and Development

scimago Q1

wos Q1

БС1

SJR: 0.865

CiteScore: 5.4

Impact factor: 3.5

ISSN: 10836160, 1520586X

DOI: 10.1021/op900311z

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Organic Chemistry

Physical and Theoretical Chemistry

Краткое описание

An improved and scalable process for the production of montelukast (Singulair, drug for asthma) based on a new and advantageous method of carrying out the key substitution reaction has been developed. The present procedure is distinguished from the previous solutions in the use of linear or cyclic polyethers, which ensures higher selectivity of the key step. The improved process for the preparation of montelukast is able to minimize a content of impurities and allows the effective production of montelukast and its scale-up.

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Halama A. et al. Improved Process for the Preparation of Montelukast: Development of an Efficient Synthesis, Identification of Critical Impurities and Degradants // Organic Process Research and Development. 2010. Vol. 14. No. 2. pp. 425-431.

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Halama A., Jirman J., Boušková O., Gibala P., Jarrah K. Improved Process for the Preparation of Montelukast: Development of an Efficient Synthesis, Identification of Critical Impurities and Degradants // Organic Process Research and Development. 2010. Vol. 14. No. 2. pp. 425-431.

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TY - JOUR

DO - 10.1021/op900311z

UR - https://doi.org/10.1021/op900311z

TI - Improved Process for the Preparation of Montelukast: Development of an Efficient Synthesis, Identification of Critical Impurities and Degradants

T2 - Organic Process Research and Development

AU - Halama, Aleš

AU - Jirman, Josef

AU - Boušková, Olga

AU - Gibala, Petr

AU - Jarrah, Kamal

PY - 2010

DA - 2010/02/11

PB - American Chemical Society (ACS)

SP - 425-431

IS - 2

VL - 14

SN - 1083-6160

SN - 1520-586X

ER -

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@article{2010_Halama,

author = {Aleš Halama and Josef Jirman and Olga Boušková and Petr Gibala and Kamal Jarrah},

title = {Improved Process for the Preparation of Montelukast: Development of an Efficient Synthesis, Identification of Critical Impurities and Degradants},

journal = {Organic Process Research and Development},

year = {2010},

volume = {14},

publisher = {American Chemical Society (ACS)},

month = {feb},

url = {https://doi.org/10.1021/op900311z},

number = {2},

pages = {425--431},

doi = {10.1021/op900311z}

}

MLA

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Halama, Aleš, et al. “Improved Process for the Preparation of Montelukast: Development of an Efficient Synthesis, Identification of Critical Impurities and Degradants.” Organic Process Research and Development, vol. 14, no. 2, Feb. 2010, pp. 425-431. https://doi.org/10.1021/op900311z.

Издатель

American Chemical Society (ACS)

Журнал

Organic Process Research and Development

scimago Q1

wos Q1

БС1

SJR

0.865

CiteScore

5.4

Impact factor

3.5

ISSN

10836160 (Print)

1520586X (Electronic)