Kilogram Synthesis of a LFA-1/ICAM Inhibitor
Publication type: Journal Article
Publication date: 2010-05-21
scimago Q1
wos Q1
SJR: 0.865
CiteScore: 5.4
Impact factor: 3.5
ISSN: 10836160, 1520586X
Organic Chemistry
Physical and Theoretical Chemistry
Abstract
The process development and the kilogram-scale synthesis of BMS-587101 (1) are described. The synthesis features a [3 + 2] azomethine ylide cycloaddition to efficiently build the spirocyclic core in a diastereoselective fashion followed by a classical resolution which affords the desired enantiomer in >98% enantiomeric excess. The target was prepared in four steps in an overall yield of 22%.
Found
Nothing found, try to update filter.
Top-30
Journals
|
1
2
|
|
|
Organic Process Research and Development
2 publications, 25%
|
|
|
Chemical Reviews
1 publication, 12.5%
|
|
|
Chemistry of Heterocyclic Compounds
1 publication, 12.5%
|
|
|
Mendeleev Communications
1 publication, 12.5%
|
|
|
1
2
|
Publishers
|
1
2
3
|
|
|
American Chemical Society (ACS)
3 publications, 37.5%
|
|
|
Springer Nature
1 publication, 12.5%
|
|
|
OOO Zhurnal "Mendeleevskie Soobshcheniya"
1 publication, 12.5%
|
|
|
1
2
3
|
- We do not take into account publications without a DOI.
- Statistics recalculated weekly.
Are you a researcher?
Create a profile to get free access to personal recommendations for colleagues and new articles.
Metrics
8
Total citations:
8
Citations from 2025:
1
(12.5%)
Cite this
GOST |
RIS |
BibTex |
MLA
Cite this
GOST
Copy
Delmonte A. J. et al. Kilogram Synthesis of a LFA-1/ICAM Inhibitor // Organic Process Research and Development. 2010. Vol. 14. No. 3. pp. 553-561.
GOST all authors (up to 50)
Copy
Delmonte A. J., Waltermire R. E., Yu F., Mcleod D. D., Gao Z., Gesenberg K. D., Girard K. P., Rosingana M., Wang X., Kuehne Willmore J., Braem A. D., Castoro J. A. Kilogram Synthesis of a LFA-1/ICAM Inhibitor // Organic Process Research and Development. 2010. Vol. 14. No. 3. pp. 553-561.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1021/op9003168
UR - https://doi.org/10.1021/op9003168
TI - Kilogram Synthesis of a LFA-1/ICAM Inhibitor
T2 - Organic Process Research and Development
AU - Delmonte, Albert J
AU - Waltermire, Robert E
AU - Yu, Fan
AU - Mcleod, Douglas D
AU - Gao, Zhinong
AU - Gesenberg, Kirsten D
AU - Girard, Kevin P
AU - Rosingana, Miguel
AU - Wang, Xuebao
AU - Kuehne Willmore, Jennifer
AU - Braem, Alan D
AU - Castoro, John A.
PY - 2010
DA - 2010/05/21
PB - American Chemical Society (ACS)
SP - 553-561
IS - 3
VL - 14
SN - 1083-6160
SN - 1520-586X
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2010_Delmonte,
author = {Albert J Delmonte and Robert E Waltermire and Fan Yu and Douglas D Mcleod and Zhinong Gao and Kirsten D Gesenberg and Kevin P Girard and Miguel Rosingana and Xuebao Wang and Jennifer Kuehne Willmore and Alan D Braem and John A. Castoro},
title = {Kilogram Synthesis of a LFA-1/ICAM Inhibitor},
journal = {Organic Process Research and Development},
year = {2010},
volume = {14},
publisher = {American Chemical Society (ACS)},
month = {may},
url = {https://doi.org/10.1021/op9003168},
number = {3},
pages = {553--561},
doi = {10.1021/op9003168}
}
Cite this
MLA
Copy
Delmonte, Albert J., et al. “Kilogram Synthesis of a LFA-1/ICAM Inhibitor.” Organic Process Research and Development, vol. 14, no. 3, May. 2010, pp. 553-561. https://doi.org/10.1021/op9003168.