Organic Process Research and Development, volume 3, issue 2, pages 139-140

A Concise Two-Step Synthesis of Thalidomide

George W. Muller ¹

William E Konnecke ¹

Alison M. SMITH ¹

Vikram D Khetani ¹

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Celgene Corporation, 7 Powder Horn Drive, Warren, New Jersey 07059 |

Publication type: Journal Article

Publication date: 1999-03-01

American Chemical Society (ACS)

Journal: Organic Process Research and Development

scimago Q1

SJR: 0.900

CiteScore: 6.9

Impact factor: 3.1

ISSN: 10836160, 1520586X

DOI: 10.1021/op980201b

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Organic Chemistry

Physical and Theoretical Chemistry

Abstract

A two-step synthesis of thalidomide is presented. The sequence requires no purifications. Treatment of l-glutamine with N-carbethoxyphthalimide produces N-phthaloyl-l-glutamine. Cyclization of N-phthaloyl-l-glutamine to afford thalidomide is accomplished by treatment with CDI in the presence of a catalytic amount of DMAP.

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64 Total citations

6 Recent citations

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GOST |

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Muller G. W. et al. A Concise Two-Step Synthesis of Thalidomide // Organic Process Research and Development. 1999. Vol. 3. No. 2. pp. 139-140.

GOST all authors (up to 50) Copy

Muller G. W., Konnecke W. E., SMITH A. M., Khetani V. D. A Concise Two-Step Synthesis of Thalidomide // Organic Process Research and Development. 1999. Vol. 3. No. 2. pp. 139-140.

RIS |

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RIS Copy

TY - JOUR

DO - 10.1021/op980201b

UR - https://doi.org/10.1021/op980201b

TI - A Concise Two-Step Synthesis of Thalidomide

T2 - Organic Process Research and Development

AU - Muller, George W.

AU - Konnecke, William E

AU - SMITH, Alison M.

AU - Khetani, Vikram D

PY - 1999

DA - 1999/03/01

PB - American Chemical Society (ACS)

SP - 139-140

IS - 2

VL - 3

SN - 1083-6160

SN - 1520-586X

ER -

BibTex |

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BibTex (up to 50 authors) Copy

@article{1999_Muller,

author = {George W. Muller and William E Konnecke and Alison M. SMITH and Vikram D Khetani},

title = {A Concise Two-Step Synthesis of Thalidomide},

journal = {Organic Process Research and Development},

year = {1999},

volume = {3},

publisher = {American Chemical Society (ACS)},

month = {mar},

url = {https://doi.org/10.1021/op980201b},

number = {2},

pages = {139--140},

doi = {10.1021/op980201b}

}

MLA

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MLA Copy

Muller, George W., et al. “A Concise Two-Step Synthesis of Thalidomide.” Organic Process Research and Development, vol. 3, no. 2, Mar. 1999, pp. 139-140. https://doi.org/10.1021/op980201b.

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Publisher

American Chemical Society (ACS)

Journal

Organic Process Research and Development

scimago Q1

SJR

0.900

CiteScore

6.9

Impact factor

3.1

ISSN

10836160 (Print)

1520586X (Electronic)