Organic Process Research and Development, volume 3, issue 2, pages 126-130
New Disulfide Route to 3-(1-Piperazinyl)-1,2-benzisothiazole. Nucleus for Atypical Antipsychotic Drugs
Stanley W. Walinsky
1
,
Darrell E. Fox
1
,
John F Lambert
1
,
Terry G Sinay
1
1
Central Research Division, Process Research and Development, Pfizer Inc., Eastern Point Road, Groton, Connecticut 06340
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Publication type: Journal Article
Publication date: 1999-02-19
scimago Q1
SJR: 0.900
CiteScore: 6.9
Impact factor: 3.1
ISSN: 10836160, 1520586X
Organic Chemistry
Physical and Theoretical Chemistry
Abstract
A new, one-step commercial process for the preparation of 3-(1-piperazinyl)-1,2-benzisothiazole hydrochloride, a key intermediate for the syntheses of some new, “atypical antipsychotic” drugs, was ...
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