Journal of Proteome Research, volume 9, issue 3, pages 1627-1634

Urinary Metabonomic Study on Colorectal Cancer

YUNPING QIU ¹

Guoxiang Cai ¹

Ming-Ming Su ¹

Tian-Lu Chen ¹

Yumin Liu ¹

Xu Ye ¹

YAN NI ¹

Ai-Hua Zhao ¹

Sanjun Cai ¹

Lisa X. Xu ¹

Jia Wei ¹

Hide authors affiliations Show authors affiliations: 1 affiliation

Department of Nutrition, University of North Carolina at Greensboro, North Carolina Research Campus, Kannapolis, North Carolina 28081, Department of Colorectal Surgery, Cancer Hospital, Fudan University and Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, P. R. China, David H. Murdock Research Institute, Kannapolis, North Carolina 28081, and Shanghai Center for Systems Biomedicine, and School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, P. R. of China

Fudan University

Shanghai Jiao Tong University

Publication type: Journal Article

Publication date: 2010-02-17

American Chemical Society (ACS)

Journal: Journal of Proteome Research

Quartile SCImago

Quartile WOS

Impact factor: 4.4

ISSN: 15353893, 15353907

DOI: 10.1021/pr901081y

Copy DOI

General Chemistry

Biochemistry

Abstract

After our serum metabonomic study of colorectal cancer (CRC) patients recently published in J. Proteome Res., we profiled urine metabolites from the same group of CRC patients (before and after surgical operation) and 63 age-matched healthy volunteers using gas chromatography−mass spectrometry (GC−MS) in conjunction with a multivariate statistics technique. A parallel metabonomic study on a 1,2-dimethylhydrazine (DMH)-treated Sprague−Dawley rat model was also performed to identify significantly altered metabolites associated with chemically induced precancerous colorectal lesion. The orthogonal partial least-squares-discriminant analysis (OPLS-DA) models of metabonomic results demonstrated good separations between CRC patients or DMH-induced model rats and their healthy counterparts. The significantly increased tryptophan metabolism, and disturbed tricarboxylic acid (TCA) cycle and the gut microflora metabolism were observed in both the CRC patients and the rat model. The urinary metabolite profile of postoperative CRC subjects altered significantly from that of the preoperative stage. The significantly down-regulated gut microflora metabolism and TCA cycle were observed in postoperative CRC subjects, presumably due to the colon flush involved in the surgical procedure and weakened physical conditions of the patients. The expression of 5-hydroxytryptophan significantly decreased in postsurgery samples, suggesting a recovered tryptophan metabolism toward healthy state. Abnormal histamine metabolism and glutamate metabolism were found only in the urine samples of CRC patients, and the abnormal polyamine metabolism was found only in the rat urine. This study assessed the important metabonomic variations in urine associated with CRC and, therefore, provided baseline information complementary to serum/plasma and tissue metabonomics for the complete elucidation of the underlying metabolic mechanisms of CRC.

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Top-30

Citations by journals

	2 4 6 8 10 12 14 16 18
Journal of Proteome Research	Journal of Proteome Research, 18, 9.94% Journal of Proteome Research 18 publications, 9.94%
Metabolomics	Metabolomics, 11, 6.08% Metabolomics 11 publications, 6.08%
Scientific Reports	Scientific Reports, 7, 3.87% Scientific Reports 7 publications, 3.87%
Metabolites	Metabolites, 6, 3.31% Metabolites 6 publications, 3.31%
Journal of Pharmaceutical and Biomedical Analysis	Journal of Pharmaceutical and Biomedical Analysis, 6, 3.31% Journal of Pharmaceutical and Biomedical Analysis 6 publications, 3.31%
Cancers	Cancers, 5, 2.76% Cancers 5 publications, 2.76%
Analytical Chemistry	Analytical Chemistry, 4, 2.21% Analytical Chemistry 4 publications, 2.21%
Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences	Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, 3, 1.66% Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences 3 publications, 1.66%
The Analyst	The Analyst, 3, 1.66% The Analyst 3 publications, 1.66%
Current Pharmacology Reports	Current Pharmacology Reports, 2, 1.1% Current Pharmacology Reports 2 publications, 1.1%
Journal of Gastroenterology	Journal of Gastroenterology, 2, 1.1% Journal of Gastroenterology 2 publications, 1.1%
Analytical and Bioanalytical Chemistry	Analytical and Bioanalytical Chemistry, 2, 1.1% Analytical and Bioanalytical Chemistry 2 publications, 1.1%
PLoS ONE	PLoS ONE, 2, 1.1% PLoS ONE 2 publications, 1.1%
Journal of Chromatography A	Journal of Chromatography A, 2, 1.1% Journal of Chromatography A 2 publications, 1.1%
Analytica Chimica Acta	Analytica Chimica Acta, 2, 1.1% Analytica Chimica Acta 2 publications, 1.1%
Cancer Letters	Cancer Letters, 2, 1.1% Cancer Letters 2 publications, 1.1%
Biomedical Chromatography	Biomedical Chromatography, 2, 1.1% Biomedical Chromatography 2 publications, 1.1%
International Journal of Cancer	International Journal of Cancer, 2, 1.1% International Journal of Cancer 2 publications, 1.1%
Expert Review of Molecular Diagnostics	Expert Review of Molecular Diagnostics, 2, 1.1% Expert Review of Molecular Diagnostics 2 publications, 1.1%
Cancer Biology and Therapy	Cancer Biology and Therapy, 2, 1.1% Cancer Biology and Therapy 2 publications, 1.1%
Evidence-based Complementary and Alternative Medicine	Evidence-based Complementary and Alternative Medicine, 2, 1.1% Evidence-based Complementary and Alternative Medicine 2 publications, 1.1%
World Journal of Gastroenterology	World Journal of Gastroenterology, 1, 0.55% World Journal of Gastroenterology 1 publication, 0.55%
Biology Open	Biology Open, 1, 0.55% Biology Open 1 publication, 0.55%
Personalized Medicine	Personalized Medicine, 1, 0.55% Personalized Medicine 1 publication, 0.55%
Future Oncology	Future Oncology, 1, 0.55% Future Oncology 1 publication, 0.55%
Oncotarget	Oncotarget, 1, 0.55% Oncotarget 1 publication, 0.55%
Cancer Biomarkers	Cancer Biomarkers, 1, 0.55% Cancer Biomarkers 1 publication, 0.55%
Molecular Medicine Reports	Molecular Medicine Reports, 1, 0.55% Molecular Medicine Reports 1 publication, 0.55%
Annals of Surgery	Annals of Surgery, 1, 0.55% Annals of Surgery 1 publication, 0.55%
	2 4 6 8 10 12 14 16 18

Citations by publishers

	5 10 15 20 25 30 35 40
Springer Nature	Springer Nature, 36, 19.89% Springer Nature 36 publications, 19.89%
Elsevier	Elsevier, 35, 19.34% Elsevier 35 publications, 19.34%
American Chemical Society (ACS)	American Chemical Society (ACS), 23, 12.71% American Chemical Society (ACS) 23 publications, 12.71%
Multidisciplinary Digital Publishing Institute (MDPI)	Multidisciplinary Digital Publishing Institute (MDPI), 15, 8.29% Multidisciplinary Digital Publishing Institute (MDPI) 15 publications, 8.29%
Wiley	Wiley, 15, 8.29% Wiley 15 publications, 8.29%
Taylor & Francis	Taylor & Francis, 7, 3.87% Taylor & Francis 7 publications, 3.87%
Royal Society of Chemistry (RSC)	Royal Society of Chemistry (RSC), 6, 3.31% Royal Society of Chemistry (RSC) 6 publications, 3.31%
Frontiers Media S.A.	Frontiers Media S.A., 5, 2.76% Frontiers Media S.A. 5 publications, 2.76%
Hindawi Limited	Hindawi Limited, 5, 2.76% Hindawi Limited 5 publications, 2.76%
Future Medicine	Future Medicine, 3, 1.66% Future Medicine 3 publications, 1.66%
American Association for Cancer Research (AACR)	American Association for Cancer Research (AACR), 3, 1.66% American Association for Cancer Research (AACR) 3 publications, 1.66%
Wolters Kluwer Health	Wolters Kluwer Health, 2, 1.1% Wolters Kluwer Health 2 publications, 1.1%
Public Library of Science (PLoS)	Public Library of Science (PLoS), 2, 1.1% Public Library of Science (PLoS) 2 publications, 1.1%
Cambridge University Press	Cambridge University Press, 2, 1.1% Cambridge University Press 2 publications, 1.1%
Baishideng Publishing Group	Baishideng Publishing Group, 1, 0.55% Baishideng Publishing Group 1 publication, 0.55%
The Company of Biologists	The Company of Biologists, 1, 0.55% The Company of Biologists 1 publication, 0.55%
Impact Journals	Impact Journals, 1, 0.55% Impact Journals 1 publication, 0.55%
IOS Press	IOS Press, 1, 0.55% IOS Press 1 publication, 0.55%
Spandidos Publications	Spandidos Publications, 1, 0.55% Spandidos Publications 1 publication, 0.55%
The Mass Spectrometry Society of Japan	The Mass Spectrometry Society of Japan, 1, 0.55% The Mass Spectrometry Society of Japan 1 publication, 0.55%
Science Alert	Science Alert, 1, 0.55% Science Alert 1 publication, 0.55%
Oxford University Press	Oxford University Press, 1, 0.55% Oxford University Press 1 publication, 0.55%
Walter de Gruyter	Walter de Gruyter, 1, 0.55% Walter de Gruyter 1 publication, 0.55%
Optical Society of America	Optical Society of America, 1, 0.55% Optical Society of America 1 publication, 0.55%
Trans Tech Publications	Trans Tech Publications, 1, 0.55% Trans Tech Publications 1 publication, 0.55%
American Physiological Society	American Physiological Society, 1, 0.55% American Physiological Society 1 publication, 0.55%
Autonomous Non-profit Organization Editorial Board of the journal Uspekhi Khimii	Autonomous Non-profit Organization Editorial Board of the journal Uspekhi Khimii, 1, 0.55% Autonomous Non-profit Organization Editorial Board of the journal Uspekhi Khimii 1 publication, 0.55%
	5 10 15 20 25 30 35 40

We do not take into account publications without a DOI.
Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
Statistics recalculated weekly.

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GOST |

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GOST Copy

QIU Y. et al. Urinary Metabonomic Study on Colorectal Cancer // Journal of Proteome Research. 2010. Vol. 9. No. 3. pp. 1627-1634.

GOST all authors (up to 50) Copy

QIU Y., Cai G., Su M., Chen T., Liu Y., Ye X., NI Y., Zhao A., Cai S., Xu L. X., Wei J. Urinary Metabonomic Study on Colorectal Cancer // Journal of Proteome Research. 2010. Vol. 9. No. 3. pp. 1627-1634.

RIS |

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RIS Copy

TY - JOUR

DO - 10.1021/pr901081y

UR - https://doi.org/10.1021/pr901081y

TI - Urinary Metabonomic Study on Colorectal Cancer

T2 - Journal of Proteome Research

AU - Liu, Yumin

AU - Cai, Sanjun

AU - QIU, YUNPING

AU - Cai, Guoxiang

AU - Su, Ming-Ming

AU - Chen, Tian-Lu

AU - Ye, Xu

AU - NI, YAN

AU - Zhao, Ai-Hua

AU - Xu, Lisa X.

AU - Wei, Jia

PY - 2010

DA - 2010/02/17 00:00:00

PB - American Chemical Society (ACS)

SP - 1627-1634

IS - 3

VL - 9

SN - 1535-3893

SN - 1535-3907

ER -

BibTex |

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BibTex Copy

@article{2010_QIU,

author = {Yumin Liu and Sanjun Cai and YUNPING QIU and Guoxiang Cai and Ming-Ming Su and Tian-Lu Chen and Xu Ye and YAN NI and Ai-Hua Zhao and Lisa X. Xu and Jia Wei},

title = {Urinary Metabonomic Study on Colorectal Cancer},

journal = {Journal of Proteome Research},

year = {2010},

volume = {9},

publisher = {American Chemical Society (ACS)},

month = {feb},

url = {https://doi.org/10.1021/pr901081y},

number = {3},

pages = {1627--1634},

doi = {10.1021/pr901081y}

}

MLA

Cite this

MLA Copy

QIU, YUNPING, et al. “Urinary Metabonomic Study on Colorectal Cancer.” Journal of Proteome Research, vol. 9, no. 3, Feb. 2010, pp. 1627-1634. https://doi.org/10.1021/pr901081y.

Found error?

Publisher

American Chemical Society (ACS)

Journal

Journal of Proteome Research

Quartile SCImago

Quartile WOS

Impact factor

4.4

ISSN

15353893 (Print)
15353907 (Electronic)