15-Deoxy-Δ12,14-prostaglandin J2: An Electrophilic Trigger of Cellular Responses
Publication type: Journal Article
Publication date: 2007-12-04
scimago Q1
wos Q2
SJR: 0.957
CiteScore: 7.5
Impact factor: 3.8
ISSN: 0893228X, 15205010
PubMed ID:
18052108
General Medicine
Toxicology
Abstract
Electrophilic molecules are endogenously generated and are causally involved in many pathophysiological effects. Prostaglandin D (20 (PGD (2)), a major cyclooxygenase product in a variety of tissues, readily undergoes dehydration to yield the cyclopentenone-type PGs of the J (2)-series such as 15-deoxy-Delta (12,14)-PGJ (2) (15d-PGJ (2)). 15d-PGJ (2) is an electrophile, which can covalently react via the Michael addition reaction with nucleophiles, such as the free sulfhydryls of glutathione and cysteine residues in cellular proteins that play an important role in the control of the redox cell-signaling pathways. Covalent binding of 15d-PGJ (2) to cellular proteins may be one of the mechanisms by which 15d-PGJ (2) induces a cellular response involved in most of the pathophysiological effects associated with inflammation. In the present perspective, we provide a comprehensive summary of 15d-PGJ (2) as an electrophilic mediator of cellular responses.
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128
Total citations:
128
Citations from 2025:
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(0.78%)
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Uchida K., Shibata T. 15-Deoxy-Δ12,14-prostaglandin J2: An Electrophilic Trigger of Cellular Responses // Chemical Research in Toxicology. 2007. Vol. 21. No. 1. pp. 138-144.
GOST all authors (up to 50)
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Uchida K., Shibata T. 15-Deoxy-Δ12,14-prostaglandin J2: An Electrophilic Trigger of Cellular Responses // Chemical Research in Toxicology. 2007. Vol. 21. No. 1. pp. 138-144.
Cite this
RIS
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TY - JOUR
DO - 10.1021/tx700177j
UR - https://doi.org/10.1021/tx700177j
TI - 15-Deoxy-Δ12,14-prostaglandin J2: An Electrophilic Trigger of Cellular Responses
T2 - Chemical Research in Toxicology
AU - Uchida, Koji
AU - Shibata, Takahiro
PY - 2007
DA - 2007/12/04
PB - American Chemical Society (ACS)
SP - 138-144
IS - 1
VL - 21
PMID - 18052108
SN - 0893-228X
SN - 1520-5010
ER -
Cite this
BibTex (up to 50 authors)
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@article{2007_Uchida,
author = {Koji Uchida and Takahiro Shibata},
title = {15-Deoxy-Δ12,14-prostaglandin J2: An Electrophilic Trigger of Cellular Responses},
journal = {Chemical Research in Toxicology},
year = {2007},
volume = {21},
publisher = {American Chemical Society (ACS)},
month = {dec},
url = {https://doi.org/10.1021/tx700177j},
number = {1},
pages = {138--144},
doi = {10.1021/tx700177j}
}
Cite this
MLA
Copy
Uchida, Koji, and Takahiro Shibata. “15-Deoxy-Δ12,14-prostaglandin J2: An Electrophilic Trigger of Cellular Responses.” Chemical Research in Toxicology, vol. 21, no. 1, Dec. 2007, pp. 138-144. https://doi.org/10.1021/tx700177j.